{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T13:37:10Z","timestamp":1791380230864,"version":"4.3.3"},"reference-count":8,"publisher":"MedWorks Media","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychopharmacol Bull"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Delusional misidentification syndromes are rare psychiatric conditions, and subjective double delusion is particularly uncommon in adolescents. Agomelatine, an antidepressant with melatonergic and serotonergic properties, has limited evidence in pediatric populations and may trigger mood instability in vulnerable individuals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Presentation<\/jats:title>\n                    <jats:p>We report the case of a 17-year-old male with a history of depressive symptoms who developed a manic episode with psychotic features shortly after initiating agomelatine. The clinical picture was dominated by a subjective double delusion, in which the patient believed an identical double existed and conspired against him. Following discontinuation of agomelatine and initiation of olanzapine, significant clinical improvement was observed within three weeks. Symptom reduction was confirmed with standardized rating scales.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This case highlights the importance of cautious antidepressant use in adolescents at risk for bipolar disorder. Clinicians should closely monitor for emerging manic or psychotic symptoms and provide timely interventions to prevent serious complications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.64719\/pb.16611","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T20:16:27Z","timestamp":1773260187000},"page":"181-186","source":"Crossref","is-referenced-by-count":1,"title":["Agomelatine-Induced Subjective Double Delusion in Adolescent Bipolar Disorder"],"prefix":"10.64719","volume":"56","author":[{"given":"Yi\u011fit","family":"\u00d6zayd\u0131n","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birsen \u015eent\u00fcrk","family":"Pilan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tezan","family":"Bildik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54175","published-online":{"date-parts":[[2026,3,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","unstructured":"Ellis HD, Young AW. Accounting for delusional misidentifications. Br J Psychiatry. 1990;157(2):239\u2013248. doi: 10.1192\/bjp.157.2.239.","DOI":"10.1192\/bjp.157.2.239"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"Green B. Focus on agomelatine. Curr Med Res Opin. 2011;27(4):745\u2013749. doi: 10.1185\/03007995.2011.555755.","DOI":"10.1185\/03007995.2011.555755"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"Macisaac SE, Carvalho AF, Cha DS, Mansur RB, McIntyre RS. The mechanism, efficacy, and tolerability profile of agomelatine. Expert Opin Pharmacother. 2014;15(2):259\u2013274. doi: 10.1517\/14656566.2014.864278.","DOI":"10.1517\/14656566.2014.864278"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"Kennel J, Baus C, Dogui R, Scemama M, Schwan R, Geoffroy PA. Agomelatine-related shift to mania in a patient with recurrent depressive disorder. Prim Care Companion CNS Disord. 2017;19(5):17l02184. doi: 10.4088\/PCC.17l02184.","DOI":"10.4088\/PCC.17l02184"},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"Barrelle A, Luaut\u00e9 JP. Capgras syndrome and other delusional misidentification syndromes. Front Neurol Neurosci. 2017;42:35\u201343. doi: 10.1159\/000475680.","DOI":"10.1159\/000475680"},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"Ellis HD, Lewis MB. Capgras delusion: a window on face recognition. Trends Cogn Sci. 2001;5(4):149\u2013156. doi: 10.1016\/S1364-6613(00)01620-X.","DOI":"10.1016\/S1364-6613(00)01620-X"},{"key":"ref7","doi-asserted-by":"publisher","unstructured":"Driscoll R, Ramalingam C, Brockman B. Capgras syndrome, mania and delusionally motivated assaults. J Forensic Psychiatry. 1991;2(1):51\u201357. doi: 10.1080\/09585189108407540.","DOI":"10.1080\/09585189108407540"},{"key":"ref8","doi-asserted-by":"publisher","unstructured":"Savino R, Polito AN, Marsala G, Calabrese F, Molteni R. Agomelatine: a potential multitarget compound for neurodevelopmental disorders. Brain Sci. 2023;13(1):43. doi: 10.3390\/brainsci13010043.","DOI":"10.3390\/brainsci13010043"}],"container-title":["Psychopharmacology Bulletin"],"original-title":[],"deposited":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T19:36:55Z","timestamp":1791315415000},"score":1,"resource":{"primary":{"URL":"https:\/\/medworksmedia.com\/pb-article\/agomelatine-induced-subjective-double-delusion-in-adolescent-bipolar-disorder\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,9]]},"references-count":8,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,3,9]]}},"URL":"https:\/\/doi.org\/10.64719\/pb.16611","relation":{},"ISSN":["2472-2448"],"issn-type":[{"value":"2472-2448","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,9]]}}}