{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T13:46:38Z","timestamp":1791380798547,"version":"4.3.3"},"reference-count":13,"publisher":"MedWorks Media","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychopharmacol Bull"],"abstract":"<jats:p>Risperidone is associated with hyperprolactinemia and its consequent symptoms such as gynnecomastia, galactorrhea and sexual dysfunction in adults, and less so in adolescents. Rarely, serotonin reuptake inhibitors are also associated with such adverse effects. We report a case of gynecomastia and galactorrhea in an adolescent male while on a combination of risperidone and fluvoxamine, although the serum prolactin was within normal range.<\/jats:p>","DOI":"10.64719\/pb.4073","type":"journal-article","created":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T11:39:16Z","timestamp":1761046756000},"page":"70-73","source":"Crossref","is-referenced-by-count":1,"title":["Euprolactinemic Gynecomastia and Galactorrhea with Risperidone-Fluvoxamine Combination"],"prefix":"10.64719","volume":"44","author":[{"given":"Pratheesh","family":"P.J.","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samir Kumar","family":"Praharaj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashish","family":"Srivastava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54175","published-online":{"date-parts":[[2025,8,12]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Haddad PM, Wieck A. Antipsychotic-induced hyperprolactinaemia: mechanisms, clinical features and management. Drugs. 2004;64:2291\u20132314.","DOI":"10.2165\/00003495-200464200-00003"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"Findling RL, Kusumakar V, Daneman D et al. Prolactin levels during long-term risperidone treatment in children and adolescents. J Clin Psychiatry. 2003;64:1362\u20131369.","DOI":"10.4088\/JCP.v64n1113"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"Kleinberg DL, Davis JM, De Coster R et al. Prolactin levels and adverse events in patients treated with risperidone. J Clin Psychopharmacol. 1999;19:57\u201361.","DOI":"10.1097\/00004714-199902000-00011"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"Holzer L, Eap CB. Risperidone-induced symptomatic hyperprolactinaemia in adolescents. J Clin Psychopharmacol. 2006;26:167\u2013171.","DOI":"10.1097\/01.jcp.0000203194.58087.9a"},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"Hall MJ. Breast tenderness and enlargement induced by sertraline. Am J Psychiatry. 1994;151: 1395\u20131396.","DOI":"10.1176\/ajp.151.9.1395b"},{"key":"ref6","doi-asserted-by":"crossref","unstructured":"Peterson MC. Reversible galactorrhea and prolactin elevation related to fluoxetine use. Mayo Clin Proc. 2001;76:215\u2013216.","DOI":"10.4065\/76.2.215"},{"key":"ref7","unstructured":"Gulsun M, Evrensel A, Verim S. Galactorrhea during escitalopram treatment: a case report. Bull Clin Psychopharmacol. 2006;16:39\u201341."},{"key":"ref8","doi-asserted-by":"crossref","unstructured":"Shim SH, Lee YJ, Lee EC. A case of galactorrhea associated with excitalopram. Psychiatry Investig. 2009;6:230\u2013232.","DOI":"10.4306\/pi.2009.6.3.230"},{"key":"ref9","doi-asserted-by":"crossref","unstructured":"Spigset O, Mjorndal T. The effect of fluvoxamine on serum prolactin and serum sodium concentrations: relation to platelet 5-HT2A receptor status. J Clin Psychopharmacol. 1997;17:292\u2013297.","DOI":"10.1097\/00004714-199708000-00009"},{"key":"ref10","doi-asserted-by":"crossref","unstructured":"D\u2019Arrigo C, Migliardi G, Santoro V et al. Effect of fluvoxamine on plasma risperidone concentrations in patients with schizophrenia. Pharmacol Res. 2005;52:497\u2013501.","DOI":"10.1016\/j.phrs.2005.09.005"},{"key":"ref11","doi-asserted-by":"crossref","unstructured":"Erzegovesi S, Guglielmo E, Siliprandi F et al. Low-dose risperidone augmentation of fluvoxamine treatment in obsessive-compulsive disorder: a double-blind, placebo-controlled study. Eur Neuropsychopharmacol. 2005;15:69\u201374.","DOI":"10.1016\/j.euroneuro.2004.04.004"},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"Gulsun M, Algul A, Semiz UB et al. A case with euprolactinemic galactorrhea induced by escitalopram. Int J Psychiatry Med. 2007;37:275\u2013278.","DOI":"10.2190\/PM.37.3.d"},{"key":"ref13","doi-asserted-by":"crossref","unstructured":"Chen CK, Huang YS, Ree SC et al. Differential add-on effects of aripiprazole in resolving hyperprolactinemia induced by risperidone in comparison to benzamide antipsychotics. Prog Neuropsychopharmacol Biol Psychiatry. 2010;34:1495\u20131499.","DOI":"10.1016\/j.pnpbp.2010.08.012"}],"container-title":["Psychopharmacology Bulletin"],"original-title":[],"deposited":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T19:25:22Z","timestamp":1791314722000},"score":1,"resource":{"primary":{"URL":"https:\/\/medworksmedia.com\/pb-article\/euprolactinemic-gynecomastia-and-galactorrhea-with-risperidone-fluvoxamine-combination\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,12]]},"references-count":13,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,8,12]]}},"URL":"https:\/\/doi.org\/10.64719\/pb.4073","relation":{},"ISSN":["2472-2448"],"issn-type":[{"value":"2472-2448","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,12]]}}}