{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T13:28:56Z","timestamp":1791379736869,"version":"4.3.3"},"reference-count":6,"publisher":"MedWorks Media","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychopharmacol Bull"],"abstract":"<jats:p>~ Nightmares are psychologically distressing events that may cause significant effects on mental health, physical well-being and overall quality of life, in addition to their negative impact on quality and duration of sleep. Drug dreams are a variant of nightmares and a known phenomenon in addiction medicine, and have been studied as a potential causative factor in relapse of substance use. Recent studies have noted that addictive behaviors and drug dreams share a similar neurobiological pathway, and that certain neurotransmitters, most notably those of the noradrenergic system, may underlie these complex processes. This has led to the theory that alleviation of drug dreams and suppression of involved neurocircuits may potentially reduce subsequent craving and relapse in the treatment of substance use disorders, with an important potential agent being the alpha-1 antagonist, prazosin.<\/jats:p>","DOI":"10.64719\/pb.4371","type":"journal-article","created":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T11:39:16Z","timestamp":1761046756000},"page":"29-31","source":"Crossref","is-referenced-by-count":0,"title":["The Use of Prazosin in Treatment of Drug Dreams in Adolescents with Substance Use Disorder: Two Case Reports"],"prefix":"10.64719","volume":"50","author":[{"given":"Arpit","family":"Aggarwal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Lindegaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54175","published-online":{"date-parts":[[2025,8,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","unstructured":"Yee T, Perantie DC, Dhanani N, Brown ES. Drug Dreams in Outpatients With Bipolar Disorder and Cocaine Dependence. The Journal of Nervous and Mental Disease. 2004;192(3):238\u2013242. doi: 10.1097\/01.nmd.0000116466.31133.f1.","DOI":"10.1097\/01.nmd.0000116466.31133.f1"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"Christo G, Franey C. Addicts\u2019 drug-related dreams: Their frequency and relationship to six-month outcomes. Subst Use Misuse. 1996;31:1\u201315.","DOI":"10.3109\/10826089609045795"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"Tanguay H, Zadra A, Good D, Leri F. Relationship Between Drug Dreams, Affect, and Craving During Treatment for Substance Dependence. Journal of Addiction Medicine. 2015;9(2):123\u2013129. doi: 10.1097\/adm.0000000000000105.","DOI":"10.1097\/adm.0000000000000105"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"Berardis D, Marini S, Serroni N et al. Targeting the Noradrenergic System in Posttraumatic Stress Disorder: A Systematic Review and Meta-Analysis of Prazosin Trials. Current Drug Targets. 2015;16(10):1094\u20131106. doi: 10.2174\/1389450116666150506114108.","DOI":"10.2174\/1389450116666150506114108"},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"Kung S, Espinel Z, Lapid MI. Treatment of Nightmares with Prazosin: A Systematic Review. Mayo Clinic Proceedings. 2012;87(9):890\u2013900. doi: 10.1016\/j.mayocp.2012.05.015.","DOI":"10.1016\/j.mayocp.2012.05.015"},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"Gopalakrishna G, Popoola O, Campbell A, Nemetalla MA. Two Case Reports on Use of Prazosin for Drug Dreams. Journal of Addiction Medicine. 2016;10(2):131\u2013133. doi: 10.1097\/adm.0000000000000194.","DOI":"10.1097\/adm.0000000000000194"}],"container-title":["Psychopharmacology Bulletin"],"original-title":[],"deposited":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T19:26:44Z","timestamp":1791314804000},"score":1,"resource":{"primary":{"URL":"https:\/\/medworksmedia.com\/pb-article\/the-use-of-prazosin-in-treatment-of-drug-dreams-in-adolescents-with-substance-use-disorder-two-case-reports\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,12]]},"references-count":6,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,8,12]]}},"URL":"https:\/\/doi.org\/10.64719\/pb.4371","relation":{},"ISSN":["2472-2448"],"issn-type":[{"value":"2472-2448","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,12]]}}}