{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T13:21:47Z","timestamp":1791379307381,"version":"4.3.2"},"reference-count":22,"publisher":"MedWorks Media","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychopharmacol Bull"],"abstract":"<jats:p>Lithium is the gold standard treatment for bipolar disorder. Studies have shown an association between lithium and hyperparathyroidism. However, there is limited data regarding the management of lithium-induced hyperparathyroidism. We present a clinical conundrum which physicians frequently encounter\u2014an excellent lithium responder refractory to other treatments who developed lithium-induced hyperparathyroidism. Medical treatment with cinacalcet was successful in management of hyperparathyroidism without discontinuing lithium maintenance therapy.<\/jats:p>","DOI":"10.64719\/pb.4410","type":"journal-article","created":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T11:39:16Z","timestamp":1761046756000},"page":"65-71","source":"Crossref","is-referenced-by-count":5,"title":["Lithium-Induced Hyperparathyroidism: An Ill-defined Territory"],"prefix":"10.64719","volume":"51","author":[{"given":"Vishwanath","family":"Pattan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Balwinder","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahar S","family":"Abdelmoneim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaitra","family":"Gopinath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vishnu","family":"Sundaresh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54175","published-online":{"date-parts":[[2025,8,12]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Baldessarini RJ, Leahy L, Arcona S, Gause D, Zhang W, Hennen J. Patterns of psychotropic drug prescription for U.S. patients with diagnoses of bipolar disorders. Psychiatr Serv. 2007;58(1):85\u201391.","DOI":"10.1176\/appi.ps.58.1.85"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"Pahwa M, Joseph B, Nunez NA et al. Long-term lithium therapy and risk of chronic kidney disease in bipolar disorder: A historical cohort study. Bipolar Disord. 2021","DOI":"10.1111\/bdi.13052"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"Kibirige D, Luzinda K, Ssekitoleko R. Spectrum of lithium induced thyroid abnormalities: a current perspective. Thyroid Res. 2013;6(1):3.","DOI":"10.1186\/1756-6614-6-3"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"Broome JT, Solorzano CC. Lithium use and primary hyperparathyroidism. Endocr Pract. 2011;17(Suppl 1):31\u201335.","DOI":"10.4158\/EP10273.RA"},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"Trepiccione F, Christensen BM. Lithium-induced nephrogenic diabetes insipidus: new clinical and experimental findings. J Nephrol. 2010;23(Suppl 16):S43\u2013S48.","DOI":"10.1093\/joneph\/23.S16.S43"},{"key":"ref6","doi-asserted-by":"crossref","unstructured":"Aksakal N, Ercetin C, Ozcinar B, Aral F, Erbil Y. Lithium-associated primary hyperparathyroidism complicated by nephrogenic diabetes insipidus. Ulus Cerrahi Derg. 2015;31(3):166\u2013169.","DOI":"10.5152\/UCD.2014.2859"},{"key":"ref7","doi-asserted-by":"crossref","unstructured":"Madkhali T, Alhefdhi A, Chen H, Elfenbein D. Primary hyperparathyroidism. Ulus Cerrahi Derg. 2016;32(1):58\u201366.","DOI":"10.5152\/UCD.2015.3032"},{"key":"ref8","doi-asserted-by":"crossref","unstructured":"Kanis JA, McCloskey EV, Johansson H, Oden A, Strom O, Borgstrom F. Development and use of FRAX in osteoporosis. 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