{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T13:46:49Z","timestamp":1791380809326,"version":"4.3.3"},"reference-count":28,"publisher":"MedWorks Media","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychopharmacol Bull"],"abstract":"<jats:p>We present the case of a young gentleman with diagnoses of bipolar affective disorder, high body mass index, and obstructive sleep apnoea. He was commenced on zuclopenthixol due to an inadequate response to quetiapine, but this swiftly led to marked physical health deterioration including shortness of breath, back pain, tachycardia, tachypnoea, and hypoxia. He was urgently transferred to hospital where he required intubation and intensive care admission.\nAFTER excluding other causes, it was felt that commencing zuclopenthixol had induced laryngo-pharyngeal dystonia leading to upper airway compromise and severely impaired respiratory function. He progressively recovered after zuclopenthixol was stopped, and he was transferred back to the psychiatric hospital after eight days.\nTHIS case highlights the potential challenges in diagnosing this rare but potentially fatal reaction to antipsychotics. We review the available literature on other cases including a potential interaction between typical antipsychotics and serotonin-specific reuptake inhibitors. Psychiatrists and emergency physicians should be aware of this condition and be alert in considering the administration of anticholinergics, which could be a simple yet life-saving intervention.<\/jats:p>","DOI":"10.64719\/pb.4428","type":"journal-article","created":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T11:39:16Z","timestamp":1761046756000},"page":"61-67","source":"Crossref","is-referenced-by-count":3,"title":["Antipsychotic-Induced Laryngeal Dystonia"],"prefix":"10.64719","volume":"52","author":[{"given":"James Richard","family":"O\u2019Neill","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clare","family":"Stephenson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54175","published-online":{"date-parts":[[2025,8,12]]},"reference":[{"key":"ref1","unstructured":"Taylor DM, Barnes TRE, Young AH. The Maudsley Prescribing Guidelines in Psychiatry. 13th. Wiley Blackwell; Chichester: 2018."},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"Hauser RA, Meyer JM, Factor SA, Comella CL, Tanner CM, Xavier RM, Caroff SN, Lundt L. Differentiating tardive dyskinesia: a video-based review of antipsychotic-induced movement disorders in clinical practice. CNS Spectr. 2020;25:1\u201310.","DOI":"10.1017\/S109285292000200X"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"McGeer EG, McGeer PL. The dystonias. Can J Neurol Sci. 1988;15:447\u2013483.","DOI":"10.1017\/S0317167100028304"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"Lanzaro M, Petrone R, D\u2019Ambrosio A. Successful treatment with clozapine in a patient with neuroleptic-induced acute laryngeal dystonia. Eur Psychiatry. 2001;16:261\u2013262.","DOI":"10.1016\/S0924-9338(01)00576-4"},{"key":"ref5","unstructured":"Johnstone EC, Cunningham Owens DG, Lawrie SM, Sharpe M, Freeman CPL. Companion to psychiatric studies. 7th. 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