{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T13:43:42Z","timestamp":1791380622241,"version":"4.3.3"},"reference-count":24,"publisher":"MedWorks Media","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychopharmacol Bull"],"abstract":"<jats:p>The mechanism of many neuropsychiatric disorders remains unknown, but the ineffectiveness of the sodium channel blocker lidocaine has been suggested to be a biomarker for Attention Deficit Hyperactivity Disorder (ADHD) and a severe form of Premenstrual Syndrome (PMS) that is considered psychiatric. We conducted single-arm double-blind clinical trials to test whether lidocaine ineffectiveness can be used as a biomarker to identify people with these conditions and provide a clue as to the molecular mechanism and potential psychopharmacological intervention. Experimental Design: We developed a noninvasive taste test for lidocaine ineffectiveness, validated by comparing lidocaine injections to pain testing in 12 subjects, and assessed it in individuals with ADHD and PMS. Principal Observations: Lidocaine ineffectiveness had a strong association in women with ADHD + PMS in a sample of 53 subjects and controls (p &amp;lt; 0.001). Conclusions: These results suggest the possibility of the biological understanding of the combination of ADHD and PMS that is characteristic of the psychiatric disorder Premenstrual Dysphoric Disorder (PMDD). These results and comparison to family pedigrees of a neuromuscular channelopathy with overlapping symptoms suggest the possibility that the clinical phenotype in PMDD is produced by sensory overstimulation, and amenable to molecular understanding and treatment.<\/jats:p>","DOI":"10.64719\/pb.4441","type":"journal-article","created":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T11:39:16Z","timestamp":1761046756000},"page":"20-30","source":"Crossref","is-referenced-by-count":2,"title":["Lidocaine Ineffectiveness Suggests New Psychopharmacology Drug Target"],"prefix":"10.64719","volume":"52","author":[{"given":"Mark","family":"Mintz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Badner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn K.","family":"Feldman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pnina","family":"Mintz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mana","family":"Saraghi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Diaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"Mezhebovsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Axelrod","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Gleeson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cathy","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Chow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Zurakowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael M.","family":"Segal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54175","published-online":{"date-parts":[[2025,8,12]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Segal MM, Rogers GF, Needleman HL, Chapman CA. 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[14 March 2022];2022 All of Us. https:\/\/allofus.nih.gov\/ Accessed."},{"key":"ref7","doi-asserted-by":"crossref","unstructured":"Nakai Y, Milgrom P, Mancl L et al. Effectiveness of Local Anesthesia in Pediatric Dental Practice. J Am Dent Assoc. 2000;131:1699\u20131705.","DOI":"10.14219\/jada.archive.2000.0115"},{"key":"ref8","doi-asserted-by":"crossref","unstructured":"Endicott J, Nee J, Harrison W. Daily Record of Severity of Problems (DRSP): Reliability and Validity. Arch Womens Ment Health. 2006;9:41\u201349.","DOI":"10.1007\/s00737-005-0103-y"},{"key":"ref9","doi-asserted-by":"crossref","unstructured":"Halbreich U, Borenstein J, Pearlstein T, Kahn LS. The Prevalence, Impairment, Impact, and Burden of Premenstrual Dysphoric Disorder (PMS\/PMDD) Psychoneuroendocrinology. 2003;28(Suppl 3):1\u201323.","DOI":"10.1016\/S0306-4530(03)00098-2"},{"key":"ref10","doi-asserted-by":"crossref","unstructured":"Pilver CE, Libby DJ, Hoff RA. 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Longitudinal Population-based Twin Study of Retrospectively Reported Premenstrual Symptoms and Lifetime Major Depression. Am J Psychiatry. 1998;155:1234\u20131240.","DOI":"10.1176\/ajp.155.9.1234"},{"key":"ref15","doi-asserted-by":"crossref","unstructured":"Schmidt PJ, Nieman LK, Danaceau MA et al. Differential Behavioral Effects of Gonadal Steroids in Women with and in Those without Premenstrual Syndrome. N Engl J Med. 1998;338:209\u2013216.","DOI":"10.1056\/NEJM199801223380401"},{"key":"ref16","doi-asserted-by":"crossref","unstructured":"Wyatt KM, Dimmock PW, Ismail KM et al. The Effectiveness of GnRHa With and Without \u2018add-back\u2019 Therapy in Treating Premenstrual Syndrome: A Meta Analysis. BJOG. 2004;111:585\u2013593.","DOI":"10.1111\/j.1471-0528.2004.00135.x"},{"key":"ref17","unstructured":"Weber F, Lehmann-Horn F. Hypokalemic Periodic Paralysis. [14 March 2022];2018 GeneReviews. https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK1338\/ Accessed."},{"key":"ref18","doi-asserted-by":"crossref","unstructured":"Levitt JO. Practical Aspects in the Management of Hypokalemic Periodic Paralysis. J Translational Medicine. 2008;6:18.","DOI":"10.1186\/1479-5876-6-18"},{"key":"ref19","doi-asserted-by":"crossref","unstructured":"Kennedy SH, Eisfeld BS, Dickens SE et al. Antidepressant-induced Sexual Dysfunction During Treatment with Moclobemide, Paroxetine, Sertraline, and Venlafaxine. J Clin Psychiatry. 2000;1:276\u2013281.","DOI":"10.4088\/JCP.v61n0406"},{"key":"ref20","doi-asserted-by":"crossref","unstructured":"Pearlstein T, Steiner M. Premenstrual Dysphoric Disorder: Burden of Illness and Treatment Update. J Psychiatry Neurosci. 2008;33:291\u2013301.","DOI":"10.1139\/jpn.0828"},{"key":"ref21","doi-asserted-by":"crossref","unstructured":"Graf WD, Miller G, Nagel SK. Addressing the Problem of ADHD Medication as Neuroenhancements. Expert Rev Neurother. 2014;14:569\u2013581.","DOI":"10.1586\/14737175.2014.908707"},{"key":"ref22","doi-asserted-by":"crossref","unstructured":"Clemow DB. Misuse of Methylphenidate. Curr Top Behav Neurosci. 2017;34:99\u2013124.","DOI":"10.1007\/7854_2015_426"},{"key":"ref23","doi-asserted-by":"crossref","unstructured":"Hartlage SA, Breaux CA, Yonkers KA. Addressing Concerns About the Inclusion of Premenstrual Dysphoric Disorder in DSM-5. J Clin Psychiatry. 2014;75:70\u201376.","DOI":"10.4088\/JCP.13cs08368"},{"key":"ref24","doi-asserted-by":"crossref","unstructured":"Steiner M, Peer M, Macdougall M, Haskett R. The Premenstrual Tension Syndrome Rating Scales: An Updated Version. 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