{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T13:18:26Z","timestamp":1791379106276,"version":"4.3.2"},"reference-count":26,"publisher":"MedWorks Media","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychopharmacol Bull"],"abstract":"<jats:p>Introduction\nThe period before effective treatment is administered, is known as the duration of untreated illness (DUI). It has been found to relate to prognoses and sensitivity to treatment. The DUI is yet to be fully investigated in relation to obsessive-compulsive disorder (OCD).\nMethod\nThe present study examined a sample of 89 patients who presented with OCD over a span of two years and who were treated at a clinic in Khartoum, the capital city of Sudan. We examined the mean DUI before the patients received an effective psychiatric intervention. We also gauged different sociodemographic and clinical presentations associated with DUI.\nResults\nThe sample comprised 55 male (61.8%) and 34 female patients (38.2%). Around 75% were single (N = 67); 34 participants (38.2%) were students; 28 (31.5%) were employed; and 27 (30.3%) were unemployed. The mean age of the participants was 27.12 years (SD \u00b1 8.72) and the mean age at the first onset of the disorder was 21.72 years (SD \u00b1 7.51). The mean of DUI was 5.41 years (SD \u00b1 5.53). There was no significant difference in DUI in respect of age or gender. It was significantly longer in unemployed patients (7.59 years \u00b1 5.93) than in employed (6.37 years \u00b1 6.64) or students (2.88 years \u00b1 2.59); p = 0.002. Married OCD patients had a longer DUI than single patients.\nConclusion\nThe present study highlighted a considerable delay before OCD patients received effective treatment. Although many intractable cultural and socioeconomic factors were tested, the strongest associations were found to be unemployment and marital status.<\/jats:p>","DOI":"10.64719\/pb.4480","type":"journal-article","created":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T11:39:16Z","timestamp":1761046756000},"page":"25-32","source":"Crossref","is-referenced-by-count":1,"title":["Duration of Untreated Illness in Obsessive-Compulsive Disorder and its Associated Factors"],"prefix":"10.64719","volume":"54","author":[{"given":"Anas Ibn","family":"Auf","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdelgadir","family":"Osman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54175","published-online":{"date-parts":[[2025,8,12]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Fineberg NA, Baldwin DS, Menchon JM et al. Manifesto for a European Research Network into Obsessivecompulsive and Related Disorders. Eur. Neuropsychopharmacol. 2013;23:561\u2013568. doi: 10.1016:2012.10.1016\/j.","DOI":"10.1016\/j.euroneuro.2012.06.006"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"Fontenelle LF, Mendlowicz MV, Versiani M. The Descriptive Epidemiology of Obsessive-Compulsive Disorder. Prog Neuropsychopharmacol Biol Psychiatry. 2006;30:327\u2013337. doi: 10.1016\/j.pnpbp.2005.11.001.","DOI":"10.1016\/j.pnpbp.2005.11.001"},{"key":"ref3","unstructured":"Kiejna A, Rymaszewska J, Kantorska-Janiec M, Tokarski W. Epidemiology of Obsessive-Compulsive Disorder. Psychiatry Pol. 36:539\u2013548."},{"key":"ref4","unstructured":"Gururaj G, Varghese M, Benegal V et al. National Mental Health Survey of India, 2015\u201316: Summary Report. Bengaluru: National Institute of Mental Health and Neurosciences. 2016"},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 5th ed. Washington D.C. 2013 doi: 10.1176\/appi.books.9780890425596.","DOI":"10.1176\/appi.books.9780890425596"},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"de Mathis MA, Diniz JB, Hounie AG et al. Trajectory in Obsessivecompulsive Disorder Comorbidities. Eur Neuropsychopharmacol. 2013;23:594\u2013601. doi: 10.1016\/j.euroneuro.2012.08.006. Epub 2012 Aug 22.","DOI":"10.1016\/j.euroneuro.2012.08.006"},{"key":"ref7","doi-asserted-by":"publisher","unstructured":"Delorme R, Golmard JL, Chabane N et al. Admixture Analysis of Age at Onset in Obsessive-Compulsive Disorder. Psychol Med. 2005;35:237\u2013243. doi: 10.1017\/s0033291704003253.","DOI":"10.1017\/s0033291704003253"},{"key":"ref8","doi-asserted-by":"publisher","unstructured":"Ruscio AM, Stein DJ, Chiu WT, Kessler RC. The Epidemiology of Obsessive-Compulsive Disorder in the National Comorbidity Survey Replication. Mol Psychiatry. 2010;15:53\u201363. doi: 10.1038\/mp.2008.94.","DOI":"10.1038\/mp.2008.94"},{"key":"ref9","doi-asserted-by":"publisher","unstructured":"Hollander E, Wong C. Psychosocial Functions and Economic Costs of Obsessive Compulsive Disorder. CNS Spectrums. 1998;3:48\u201358. doi: 10.1017\/S1092852900007239.","DOI":"10.1017\/S1092852900007239"},{"key":"ref10","doi-asserted-by":"publisher","unstructured":"Heyman I, Mataix-Cols D, Fineberg NA. Obsessive-Compulsive Disorder. BMJ. 2006;333:424\u2013429. doi: 10.1136\/bmj.333.7565.424.","DOI":"10.1136\/bmj.333.7565.424"},{"key":"ref11","doi-asserted-by":"publisher","unstructured":"Poyraz CA, Turan \u015e, Saglam NG, Batun G\u00c7, Yassa A, Duran A. Factors Associated with the Duration of Untreated Illness Among Patients with Obsessive Compulsive Disorder. Compr Psychiatry. 2015;58:88\u201393. doi: 10.1016\/j.comppsych.2014.12.019.","DOI":"10.1016\/j.comppsych.2014.12.019"},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"Altamura AC, Buoli M, Serati M. Duration of Illness and Duration of Untreated Illness in Relation to Drug Response in Psychiatric Disorders. Neuropsychiatry. 2011;1:81\u201390.","DOI":"10.2217\/npy.10.2"},{"key":"ref13","doi-asserted-by":"publisher","unstructured":"Dell\u2019Osso B, Altamura AC. Duration of Untreated Psychosis and Duration of Untreated Illness: New Vistas. CNS Spectr. 15 doi: 10.1017\/s1092852900000079.","DOI":"10.1017\/s1092852900000079"},{"key":"ref14","doi-asserted-by":"publisher","unstructured":"Reddy YC, D\u2019Souza SM, Shetti C et al. An 11- to 13-Year Follow-Up of 75 Subjects with Obsessivecompulsive Disorder. J Clin Psychiatry. 2005;66:744\u2013749. doi: 10.4088\/jcp.v66n0611.","DOI":"10.4088\/jcp.v66n0611"},{"key":"ref15","doi-asserted-by":"publisher","unstructured":"Albert U, Barbaro F, Bramante S, Rosso G, De Ronchi D, Maina G. Duration of Untreated Illness and Response to SRI Treatment in Obsessive-Compulsive Disorder. Eur Psychiatry. 2019;58:19\u201326. doi: 10.1016\/j.eurpsy.2019.01.017. Epub 2019 Feb 11.","DOI":"10.1016\/j.eurpsy.2019.01.017"},{"key":"ref16","doi-asserted-by":"publisher","unstructured":"Thomsen PH, Mikkelsen HU. Course of Obsessive-Compulsive Disorder in Children and Adolescents: A Prospective Follow-Up Study of 23 Danish Cases. J Am Acad Child Adolesc Psychiatry. 1995;34:1432\u20131440. doi: 10.1097\/00004583-199511000-00009.","DOI":"10.1097\/00004583-199511000-00009"},{"key":"ref17","doi-asserted-by":"publisher","unstructured":"De Luca V, Gershenzon V, Burroughs E, Javaid N, Richter MA. Age at Onset in Canadian OCD Patients: Mixture Analysis and Systematic Comparison with other Studies. J Affect Disord. 2011;133:300\u2013304. doi: 10.1016\/j.jad.2011.03.041.","DOI":"10.1016\/j.jad.2011.03.041"},{"key":"ref18","doi-asserted-by":"publisher","unstructured":"Grant JE, Mancebo MC, Pinto A, Williams KA, Eisen JL, Rasmussen SA. Late-Onset Obsessive Compulsive Disorder: Clinical Characteristics and Psychiatric Comorbidity. Psychiatry Res. 2007;152:21\u201327. doi: 10.1016\/j.psychres.2006.09.015.","DOI":"10.1016\/j.psychres.2006.09.015"},{"key":"ref19","doi-asserted-by":"publisher","unstructured":"Dell\u2019Osso B, Benatti B, Buoli M et al. The Influence of Age at Onset and Duration of Illness on Longterm Outcome in Patients with Obsessive-Compulsive Disorder: A Report from the International College of Obsessive Compulsive Spectrum Disorders (ICOCS) Eur Neuropsychopharmacol. 2013;23:865\u2013871. doi: 10.1016\/j.euroneuro.2013.05.004.","DOI":"10.1016\/j.euroneuro.2013.05.004"},{"key":"ref20","doi-asserted-by":"publisher","unstructured":"Vigne P, Fortes P, Dias RV et al. Duration of Untreated Illness in a Cross-Diagnostic Sample of Obsessivecompulsive Disorder, Panic Disorder, and Social Anxiety Disorder. CNS Spectr. 2019;24:526\u2013532. doi: 10.1017\/S1092852918001281.","DOI":"10.1017\/S1092852918001281"},{"key":"ref21","doi-asserted-by":"publisher","unstructured":"Dell\u2019Osso B, Benatti B, Oldani L, Spagnolin G, Altamura AC. Differences in Duration of Untreated Illness, Duration, and Severity of Illness Among Clinical Phenotypes of Obsessive-Compulsive Disorder. CNS Spectr. 2015;20:474\u2013478. doi: 10.1017\/S1092852914000339.","DOI":"10.1017\/S1092852914000339"},{"key":"ref22","doi-asserted-by":"publisher","unstructured":"Matsumoto Y, Nakamae T, Abe Y, Watanabe A, Narumoto J. Duration of Untreated Illness of Patients with Obsessive-Compulsive Disorder in Japan. Early Interv Psychiatry. 2021;15:1644\u20131649. doi: 10.1111\/eip.13105.","DOI":"10.1111\/eip.13105"},{"key":"ref23","doi-asserted-by":"publisher","unstructured":"Osman A, Bakhiet A, Elmusharaf S, Omer A, Abdelrahman A. Sudan\u2019s Mental Health Service: Challenges and Future Horizons. BJPsych Int. 13 doi: 10.1192\/bji.2019.19.","DOI":"10.1192\/bji.2019.19"},{"key":"ref24","doi-asserted-by":"publisher","unstructured":"Hathorn SK, Lochner C, Stein DJ, Bantjes J. Help-Seeking Intention in Obsessive-Compulsive Disorder: Predictors and Barriers in South Africa. Front Psychiatry. 2021;24:733\u2013773. doi: 10.3389\/fpsyt.2021.733773.","DOI":"10.3389\/fpsyt.2021.733773"},{"key":"ref25","doi-asserted-by":"publisher","unstructured":"Ibn Auf AI, Osman M. Phenomenology of Obsessive-Compulsive Disorder in Sudan and its Association with Socio-Demographic Factors. Indian Journal of Mental Health. 2022;9(4):372. doi: 10.30877\/IJMH.9.4.2022.371-376.","DOI":"10.30877\/IJMH.9.4.2022.371-376"},{"key":"ref26","doi-asserted-by":"publisher","unstructured":"Ziegler S, Bednasch K, Baldofski S, Rummel-Kluge C. Long Durations from Symptom Onset to Diagnosis and from Diagnosis to Treatment in Obsessive-Compulsive Disorder: A Retrospective Self-Report Study. 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