{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T13:39:22Z","timestamp":1791380362133,"version":"4.3.3"},"reference-count":9,"publisher":"MedWorks Media","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychopharmacol Bull"],"abstract":"<jats:p>Hyponatraemia is a well-established and potentially, a life-threatening adverse effect of selective serotonin receptor uptake inhibitors (SSRI). However, its occurrence secondary to syndrome of inappropriate antidiuretic hormone secretion (SIADH) with escitalopram, has been reported extremely sporadically. The reporting of such rare, but life-threatening adverse effects of escitalopram assumes immense significance in light of the fact that SSRIs presently form the mainstay of treatment of depressive disorders. Here, we report a case where a 58 year old diabetic lady, when initiated on escitalopram for dysthymia developed severe hyponatraemia within 2 weeks. Further, we discuss other relevant cases that have been reported in the past with an eye on the management of SIADH and hyponatraemia.<\/jats:p>","DOI":"10.64719\/pb.4552","type":"journal-article","created":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T11:39:16Z","timestamp":1761046756000},"page":"52-55","source":"Crossref","is-referenced-by-count":0,"title":["Escitalopram Induced SIADH in an Elderly Female: A Case Study"],"prefix":"10.64719","volume":"47","author":[{"given":"Sudha","family":"Vidyasagar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karthik","family":"Rao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muralidhar","family":"Verma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aswini Dutt","family":"Tripuraneni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Navin","family":"Patil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dipanjan","family":"Bhattacharjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54175","published-online":{"date-parts":[[2025,8,12]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Nashoni E, Weizman A, Shefet D, Pik N. A case of hyponatremia associated with escitalopram. J Clin Psychiatry. 2004;65:1772.","DOI":"10.4088\/JCP.v65n1219c"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"Covyeou JA, Jackson CW. Hyponatremia associated with escitalopram. N Engl J Med. 2007;356(1):94\u201395.","DOI":"10.1056\/NEJMc062840"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"Grover S, Biswas PS, Bhateja G, Kulhara P. Escitalopram associated hyponatremia. Psychiatry Clin Neurosci. 2007;61:132\u2013133.","DOI":"10.1111\/j.1440-1819.2007.01625.x"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"Tsai PH, Chen HC, Liao SC, Tseng MC, Lee MB. Recurrent escitalopram-induced hyponatremia in an elderly woman with dementia with Lewy bodies. Gen Hosp Psychiatry. 2012;34(1):5\u20137.","DOI":"10.1016\/j.genhosppsych.2011.06.007"},{"key":"ref5","unstructured":"Kar SK, Sharma MP. Hyponatremia: a rare, life threatening side effect of escitalopram. Indian Journal of Behavioural Sciences. 2014;24(1):65\u201367."},{"key":"ref6","doi-asserted-by":"crossref","unstructured":"Chan TY. Drug induced syndrome of inappropriate antidiuretic hormone secretion. Causes, diagnosis and management. Drugs & Aging. 1997;11:27\u201344.","DOI":"10.2165\/00002512-199711010-00004"},{"key":"ref7","unstructured":"Liu B, Mittman N, Knowles SR, Shear NH. Hyponatremia and syndrome of inappropriate secretion of antidiuretic hormone associated with the use of selective serotonin reuptake inhibitors: a review of spontaneous reports. Can Med Assoc J. 1996;155:519\u2013527."},{"key":"ref8","doi-asserted-by":"crossref","unstructured":"Ellison DH, Berl T. The syndrome of inappropriate antidiuresis. N Engl J Med. 2007;356:2064\u20132072.","DOI":"10.1056\/NEJMcp066837"},{"key":"ref9","doi-asserted-by":"crossref","unstructured":"Naranjo CA, Busto U, Sellers EM, Sandor P, Ruiz I, Roberts EA et al. A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther. 1981;30:239\u2013245.","DOI":"10.1038\/clpt.1981.154"}],"container-title":["Psychopharmacology Bulletin"],"original-title":[],"deposited":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T19:33:52Z","timestamp":1791315232000},"score":1,"resource":{"primary":{"URL":"https:\/\/medworksmedia.com\/pb-article\/escitalopram-induced-siadh-in-an-elderly-female-a-case-study\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,12]]},"references-count":9,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,8,12]]}},"URL":"https:\/\/doi.org\/10.64719\/pb.4552","relation":{},"ISSN":["2472-2448"],"issn-type":[{"value":"2472-2448","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,12]]}}}