{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T13:43:58Z","timestamp":1791380638141,"version":"4.3.3"},"reference-count":5,"publisher":"MedWorks Media","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychopharmacol Bull"],"abstract":"<jats:p>Progressive non-familial adult onset cerebellar degeneration has been rarely associated with hypothyroidism and is known to be reversible after therapy. We report a case of cerebellar atrophy in a 31 year old female whose detailed evaluation had revealed sub-clinical hypothyroidism secondary to autoimmune thyroiditis with a very high anti-TPO (anti-thyroid peroxidase) antibody levels. MRI (Magnetic Resonanace Imaging) of brain showed diffuse bilateral cerebellar atrophy. She was treated with thyroid hormone supplementation and after one year of follow up, cerebellar signs had disappeared completely with significant reduction in anti-TPO antibody levels. Imaging of the brain post one year of follow-up revealed normal cerebellum. Hence, we opine that thyroid dysfunction should always be kept in mind while evaluating patients presenting with acute onset cerebellar ataxia as it can be easily reversed with thyroid hormone replacement therapy.<\/jats:p>","DOI":"10.64719\/pb.4566","type":"journal-article","created":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T11:39:16Z","timestamp":1761046756000},"page":"42-46","source":"Crossref","is-referenced-by-count":0,"title":["Progressive Non-familial Adult onset Cerebellar Degeneration: An Unusual Occurrence with Hashimoto\u2019s Thyroiditis"],"prefix":"10.64719","volume":"48","author":[{"given":"Raghavendra S.","family":"Rao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shubha","family":"Sheshadri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dipanjan","family":"Bhattacharjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Navin","family":"Patil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karthik","family":"Rao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54175","published-online":{"date-parts":[[2025,8,12]]},"reference":[{"key":"ref1","unstructured":"Pavan MR, Deepak M, Basavaprabhu A, Gupta A. Doctor I Am Swaying: An Interesting Case of Ataxia. J Clin Diagn Res. 2012;6(4):702\u2013703."},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"Shneyder NV, Lyons MK, Driver-Dunckley E, Evidente VGH. Cerebellar ataxia from multiple potential causes: hypothyroidism, Hashimoto\u2019s thyroiditis, thalamic stimulation, and essential tremor, Tremor Other Hyperkinet Mov. 2012;2 tre-02-44-309-2 http:\/\/dx.doi.org\/10.7916\/D8BP01H5.","DOI":"10.7916\/D8BP01H5"},{"key":"ref3","unstructured":"Tanaka M, Kawarabayashi T, Okamoto K, Morimatsu M, Hirai S. Reduction of cerebral blood flow and metabolic rate of oxygen in a case of hypothyroidism presenting with cerebellar ataxia. Rinsho Shinkeigaku. 1987;27:1262\u20131265."},{"key":"ref4","unstructured":"Chiu A, Sherman S. Clinical manifestations and differential diagnosis of hypothyroidism. In: Falk SA, editor. Thyroid disease: endocrinology, surgery, nuclear medicine, and Radiotherapy. Philadelphia: Lippincott-Raven; 1997. pp. 379\u2013391."},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"Zuchenko O, Bailey J, Bonnen P, Ashizawa T, Stockton DW, Amos C et al. Autosomal dominant cerebellar ataxia (SCA6) associated with small polyglutamine expansions in the \u00e1 1A-voltage-dependent calcium channel. Nature Genet. 1997;15:62\u201369.","DOI":"10.1038\/ng0197-62"}],"container-title":["Psychopharmacology Bulletin"],"original-title":[],"deposited":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T19:34:22Z","timestamp":1791315262000},"score":1,"resource":{"primary":{"URL":"https:\/\/medworksmedia.com\/pb-article\/progressive-non-familial-adult-onset-cerebellar-degeneration-an-unusual-occurrence-with-hashimotos-thyroiditis\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,12]]},"references-count":5,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025,8,12]]}},"URL":"https:\/\/doi.org\/10.64719\/pb.4566","relation":{},"ISSN":["2472-2448"],"issn-type":[{"value":"2472-2448","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,12]]}}}