{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T01:54:18Z","timestamp":1791942858011,"version":"4.3.4"},"reference-count":26,"publisher":"MedWorks Media","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychopharmacol Bull"],"abstract":"<jats:p>Purpose of Review:\nThis is a comprehensive review of the association between cannabis use and psychological disorders. It reviews the latest and seminal evidence that is available and attempts to conclude the strength of such association.\nRecent Findings:\nCannabis is a flowering plant with psychoactive properties, attributed to cannabinoids that naturally occur within the plant. These act through the CB1 and CB2 receptors to inhibit GABA and glutamate release, as well through other forms of neuromodulation through the modulation of the endocannabinoid system (eCBs); a system that is otherwise involved in different pathways, including reward, memory, learning, and pain. Recent societal changes have increased the use of both medical and recreational cannabis. Patients with mental illness are considered more vulnerable and are prone to reward-seeking behavior. Cannabis use disorder (CUD) has been shown to have an increased prevalence in individuals with mental illness, creating an explosive cocktail. Approximately 1 in 4 patients with schizophrenia are also diagnosed with CUD. Cannabis use is associated with 2\u20134 times the likelihood of developing psychosis in healthy individuals. It has also been associated with multiple poor prognostic factors in schizophrenia, as well as in patients with a history of psychosis who do not meet diagnostic criteria for schizophrenia. Cannabis has been linked with anxiety; THC has been shown to elicit anxiety; however, anxiety is also a trigger for cannabis use. However, a recent large meta-analysis did not find a convincing link between cannabis and anxiety. This was reiterated in a recent epidemiological study that did not find such a correlation; however, it did identify a link between cannabis use, substance disorder, alcohol use disorder, drug use disorder, and nicotine dependence. Similarly, contradicting data exists regarding the link of depression and cannabis use.\nSummary:\nCannabis use is increasing with recent societal shifts; however, its interaction with mental health is less well understood. CUD is highly prevalent in individuals with mental health disorders, especially those with other substance abuse disorders. There is evidence to support that cannabis use may trigger and worsen psychosis and schizophrenia. The link with depression and anxiety is less clear and needs further investigation. Personality disorder is linked with substance use disorder and shares similar risk factors with CUD.<\/jats:p>","DOI":"10.64719\/pb.4606","type":"journal-article","created":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T11:23:34Z","timestamp":1761045814000},"page":"56-67","source":"Crossref","is-referenced-by-count":36,"title":["Cannabis Use and its Association with Psychological Disorders"],"prefix":"10.64719","volume":"50","author":[{"given":"Ivan","family":"Urits","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyle","family":"Gress","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karina","family":"Charipova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amnon A.","family":"Berger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elyse M.","family":"Cornett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamal","family":"Hasoon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisham","family":"Kassem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan D.","family":"Kaye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Viswanath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54175","published-online":{"date-parts":[[2025,8,12]]},"reference":[{"key":"ref1","unstructured":"Turgeman I, Bar-Sela G. Cannabis use in palliative oncology: A review of the evidence for popular indications. Isr Med Assoc J. 2017;19:85\u201388."},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"Nestoros JN, Vakonaki E, Tzatzarakis MN, Alegakis A, Skondras MD, Tsatsakis AM. Long Lasting Effects of Chronic Heavy Cannabis Abuse. Am J Addict. 2017;26:335\u2013342.","DOI":"10.1111\/ajad.12529"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"Borgan F, Beck K, Butler E, Mccutcheon R, Veronese M, Vernon A, Howes OD. The effects of cannabinoid 1 receptor compounds on memory: a meta-analysis and systematic review across species. Psychopharmacology (Berl) 2019","DOI":"10.1007\/s00213-019-05283-3"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"Urits I, Borchart M, Hasegawa M, Kochanski J, Orhurhu V, Viswanath O. An Update of Current Cannabis-Based Pharmaceuticals in Pain Medicine. Pain Ther. 2019;8(1):41\u201351.","DOI":"10.1007\/s40122-019-0114-4"},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"Khadrawy YA, Sawie HG, Abdel-salam OME, Hosny EN. Cannabis exacerbates depressive symptoms in rat model induced by reserpine. Behav Brain Res. 2017;324:41\u201350.","DOI":"10.1016\/j.bbr.2017.02.015"},{"key":"ref6","doi-asserted-by":"crossref","unstructured":"Lowe DJE, Sasiadek JD, Coles AS, George TP. Cannabis and mental illness: a review. Eur Arch Psychiatry Clin Neurosci. 2019;269:107\u2013120.","DOI":"10.1007\/s00406-018-0970-7"},{"key":"ref7","unstructured":"Hanson GR, Venturelli PJ, Fleckenstein AE. Drugs and Society. 2018:25."},{"key":"ref8","doi-asserted-by":"crossref","unstructured":"Chan GC, Hall W, Freeman TP, Ferris J, Kelly AB, Winstock A. User characteristics and effect profile of butane hash oil: An extremely high-potency cannabis concentrate. Drug Alcohol Depend. 2017;178:32\u201338.","DOI":"10.1016\/j.drugalcdep.2017.04.014"},{"key":"ref9","doi-asserted-by":"crossref","unstructured":"Vaucher J, Keating BJ, Lasserre AM, Gan W, Lyall DM, Ward J, Smith DJ, Pell JP, Sattar N, Par\u00e9 G, Holmes M V. Cannabis use and risk of schizophrenia: a Mendelian randomization study. Mol Psychiatry. 2018;23:1287\u20131292.","DOI":"10.1038\/mp.2016.252"},{"key":"ref10","doi-asserted-by":"crossref","unstructured":"Shah D, Chand P, Bandawar M, Benegal V, Murthy P. Cannabis induced psychosis and subsequent psychiatric disorders. Asian J Psychiatr. 2019 Oct 30;:180\u2013184. 2017.","DOI":"10.1016\/j.ajp.2017.10.003"},{"key":"ref11","doi-asserted-by":"crossref","unstructured":"Aas M, Melle I, Bettella F, Djurovic S, Hellard S Le, Bjella T, Ringen PA, Lagerberg TV, Smeland OB, Agartz I, Andreassen OA, Teslie M. Psychotic patients who used cannabis frequently before illness onset have higher genetic predisposition to schizophrenia than those who did not. Psychol Med. 2018;48:43\u201349.","DOI":"10.1017\/S0033291717001209"},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"Ortiz-Medina M, Perea M, Torales J, Ventriglio A, Vitrani G, Aguilar L, Roncero C. Cannabis consumption and psychosis or schizophrenia development. Int J Soc Psychiatry. 2018;64(7):690\u2013704.","DOI":"10.1177\/0020764018801690"},{"key":"ref13","doi-asserted-by":"crossref","unstructured":"Libuy N, Angel V De, Ib\u00e1\u00f1ez C, Murray RM, Mundt AP. The relative prevalence of schizophrenia among cannabis and cocaine users attending addiction services. Schizophr Res. 2018;194:13\u201317.","DOI":"10.1016\/j.schres.2017.04.010"},{"key":"ref14","doi-asserted-by":"crossref","unstructured":"McHugh MJ, McGorry PD, Yung AR, Lin A, Wood SJ, Hartmann JA, Nelson B. Cannabis-induced attenuated psychotic symptoms: implications for prognosis in young people at ultra-high risk for psychosis. Psychol Med. 2017;47:616\u2013626.","DOI":"10.1017\/S0033291716002671"},{"key":"ref15","doi-asserted-by":"crossref","unstructured":"Large M, Nielssen O. Daily use of high-potency cannabis is associated with an increased risk of admission and more intervention after first-episode psychosis. Evid Based Ment Heal. 2017;20(2):58.","DOI":"10.1136\/eb-2017-102630"},{"key":"ref16","doi-asserted-by":"crossref","unstructured":"Albertella L, Le Pelley ME, Copeland J. Cannabis use in early adolescence is associated with higher negative schizotypy in females. Eur Psychiatry. 2019;45(2017):235\u2013241.","DOI":"10.1016\/j.eurpsy.2017.07.009"},{"key":"ref17","doi-asserted-by":"crossref","unstructured":"Vaessen TSJ, de Jong L, Schafer AT, Damen T, Uittenboogaard A, Krolinski P, Nwosu CV, Pinckaers FME, Rotee ILM, Petrus A, Smeets W, Ermis A, Kennedy JL, Nieman DH, Tiwari A, van Os J, Drukker M. The interaction between cannabis use and the Val158Met polymorphism of the COMT gene in psychosis: A transdiagnostic meta\u2013analysis. PLoS One. 2018:1\u201322.","DOI":"10.1371\/journal.pone.0192658"},{"key":"ref18","doi-asserted-by":"crossref","unstructured":"Twomey CD. Association of cannabis use with the development of elevated anxiety symptoms in the general population: a meta-analysis. J Epidemiol Community Heal. 2017;7(8):811\u2013816.","DOI":"10.1136\/jech-2016-208145"},{"key":"ref19","doi-asserted-by":"crossref","unstructured":"Otten R, Huizink A, Monshouwer K, Creemer H, Onrust S. Cannabis use and symptoms of anxiety in adolescence and the moderating effect of the serotonin transporter gene. Addict Biol. 2017;22(4):1081\u20131089.","DOI":"10.1111\/adb.12372"},{"key":"ref20","doi-asserted-by":"crossref","unstructured":"Blanco R, Parras T, McDonnell J, Prats-Galino A. Serratus plane block: a novel ultrasound-guided thoracic wall nerve block. Anaesthesia. 2013;68:1107\u20131113.","DOI":"10.1111\/anae.12344"},{"key":"ref21","doi-asserted-by":"crossref","unstructured":"Orhurhu V, Olusunmade M, Akinola Y, Urits I, Orhurhu MS, Viswanath O, Hirji S, Kaye AD, Simopoulos T, Gill JS. Depression Trends in Patients with Chronic Pain: An Analysis of the Nationwide Inpatient Sample. Pain Physician. 2019;22(5):E487\u2013E494.","DOI":"10.36076\/ppj\/2019.22.E487"},{"key":"ref22","doi-asserted-by":"crossref","unstructured":"Vwaire Orhurhu, Ivan Urits, Mayowa Olusunmade, Khurram Owais, Mark Jones. Annemarie Galasso, Mariam Salisu Orhurhu, Mohammed Issa. Trends of Co-Morbid Depression in Hospitalized Patients with Failed Back Surgery Syndrome: An Analysis of the Nationwide Inpatient Sample. Pain Ther. 2018","DOI":"10.1007\/s40122-018-0104-y"},{"key":"ref23","doi-asserted-by":"crossref","unstructured":"Urits I, Peck J, Orhurhu MS, Wolf J, Patel R, Orhurhu V, Kaye AD, Viswanath O. Off-label Antidepressant Use for Treatment and Management of Chronic Pain: Evolving Understanding and Comprehensive Review [Internet] 2019;23:66. Current Pain and Headache Reports. Current Medicine Group LLC 1.","DOI":"10.1007\/s11916-019-0803-z"},{"key":"ref24","doi-asserted-by":"crossref","unstructured":"Capuco A, Urits I, Hasoon J, Chun R, Gerald B, Wang JK, Kassem H, Ngo AL, Abd-Elsayed A, Simopoulos T, Kaye AD, Viswanath O. Current Perspectives on Gut Microbiome Dysbiosis and Depression. Advances in Therapy. 2020 Adis.","DOI":"10.1007\/s11916-020-00871-x"},{"key":"ref25","doi-asserted-by":"crossref","unstructured":"Taub S, Feingold D, Rehm J, Lev-ran S. Patterns of cannabis use and clinical correlates among individuals with major depressive disorder and bipolar disorder. Compr Psychiatry. 2018;80:89\u201396.","DOI":"10.1016\/j.comppsych.2017.09.004"},{"key":"ref26","doi-asserted-by":"crossref","unstructured":"Gillespie N, Aggen S, Neale M, Knudsen G, Krueger R, South S, Czajkowski N, Nesvag R, Ystrom E, Kendler K, Reichborn-Kjennerud T. Associations between personality disorders and cannabis use and cannabis use disorder: A population-based twin study. 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