{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T11:05:22Z","timestamp":1785409522247,"version":"3.56.0"},"posted":{"date-parts":[[2025,12,3]]},"group-title":"Developmental Biology","reference-count":88,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T00:00:00Z","timestamp":1764720000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"award":["F32EY024201"],"award-info":[{"award-number":["F32EY024201"]}],"id":[{"id":"https:\/\/ror.org\/03wkg3b53","id-type":"ROR","asserted-by":"publisher"}]},{"award":["R00EY027844"],"award-info":[{"award-number":["R00EY027844"]}],"id":[{"id":"https:\/\/ror.org\/03wkg3b53","id-type":"ROR","asserted-by":"publisher"}]},{"award":["R01EY03531"],"award-info":[{"award-number":["R01EY03531"]}],"id":[{"id":"https:\/\/ror.org\/03wkg3b53","id-type":"ROR","asserted-by":"publisher"}]},{"award":["R21EY023448"],"award-info":[{"award-number":["R21EY023448"]}],"id":[{"id":"https:\/\/ror.org\/03wkg3b53","id-type":"ROR","asserted-by":"publisher"}]},{"award":["R01EY020560"],"award-info":[{"award-number":["R01EY020560"]}],"id":[{"id":"https:\/\/ror.org\/03wkg3b53","id-type":"ROR","asserted-by":"publisher"}]},{"award":["T32EY013360"],"award-info":[{"award-number":["T32EY013360"]}],"id":[{"id":"https:\/\/ror.org\/03wkg3b53","id-type":"ROR","asserted-by":"publisher"}]},{"award":["P30EY002687"],"award-info":[{"award-number":["P30EY002687"]}],"id":[{"id":"https:\/\/ror.org\/03wkg3b53","id-type":"ROR","asserted-by":"publisher"}]},{"id":[{"id":"https:\/\/ror.org\/04drjs621","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2025,12,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>\n                  Long noncoding RNAs (lncRNAs) display pervasive expression and function in the developing nervous system. Temporal profiling of gene expression in the retina has demonstrated differential expression of lncRNAs throughout development; however, determinations of lncRNA function during retinal development remain limited. In this study, we identify numerous lncRNAs with dynamic temporal expression and characterize the function of the lncRNA\n                  <jats:italic>Gm11454,<\/jats:italic>\n                  which we have named\n                  <jats:italic>Peanut<\/jats:italic>\n                  . Using overexpression of\n                  <jats:italic>Peanut<\/jats:italic>\n                  in mice retinas, we determine that\n                  <jats:italic>Peanut<\/jats:italic>\n                  promotes rod photoreceptor fate and neurogenesis of retinal progenitor cells (RPCs) via inhibition of Notch signaling and by regulating expression of neighboring gene\n                  <jats:italic>Tox2<\/jats:italic>\n                  . A novel\n                  <jats:italic>Peanut<\/jats:italic>\n                  knockout mouse model demonstrates that\n                  <jats:italic>Peanut<\/jats:italic>\n                  is required for proper visual function and photoreceptor gene expression. Finally, we determined that\n                  <jats:italic>Peanut<\/jats:italic>\n                  is necessary for proper cell cycle progression and neurogenesis. Our results characterize the function of a novel lncRNA as a regulator of RPC neurogenesis and differentiation and support the importance of lncRNAs in the developing retina.\n                <\/jats:p>","DOI":"10.64898\/2025.12.02.691925","type":"posted-content","created":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T12:49:43Z","timestamp":1765198183000},"source":"Crossref","is-referenced-by-count":0,"title":["The long noncoding RNA\n                  <i>Peanut<\/i>\n                  (\n                  <i>Gm11454<\/i>\n                  ) promotes neurogenesis and rod photoreceptor differentiation during postnatal retinal development"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5051-2288","authenticated-orcid":false,"given":"Jade Enright","family":"Hostetler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0848-6562","authenticated-orcid":false,"given":"Fion","family":"Shiau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9299-5767","authenticated-orcid":false,"given":"Shiming","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3520-6407","authenticated-orcid":false,"given":"Philip A.","family":"Ruzycki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1338-8476","authenticated-orcid":false,"given":"Seth","family":"Blackshaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7291-2055","authenticated-orcid":false,"given":"Brian S.","family":"Clark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2025120801384063000_2025.12.02.691925v1.1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.73550"},{"key":"2025120801384063000_2025.12.02.691925v1.2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu638"},{"key":"2025120801384063000_2025.12.02.691925v1.3","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2013.245"},{"key":"2025120801384063000_2025.12.02.691925v1.4","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-021-08050-x"},{"key":"2025120801384063000_2025.12.02.691925v1.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2012.05.004"},{"key":"2025120801384063000_2025.12.02.691925v1.6","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(00)80143-4"},{"key":"2025120801384063000_2025.12.02.691925v1.7","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-62703-080-9_15"},{"key":"2025120801384063000_2025.12.02.691925v1.8","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0778-05.2005"},{"key":"2025120801384063000_2025.12.02.691925v1.9","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.00825"},{"key":"2025120801384063000_2025.12.02.691925v1.10","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-0969-x"},{"key":"2025120801384063000_2025.12.02.691925v1.11","doi-asserted-by":"publisher","DOI":"10.1242\/dev.083642"},{"key":"2025120801384063000_2025.12.02.691925v1.12","doi-asserted-by":"publisher","DOI":"10.1038\/celldisc.2017.2"},{"key":"2025120801384063000_2025.12.02.691925v1.13","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2014.00164"},{"key":"2025120801384063000_2025.12.02.691925v1.14","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2019.04.010"},{"key":"2025120801384063000_2025.12.02.691925v1.15","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.ade6903"},{"key":"2025120801384063000_2025.12.02.691925v1.16","doi-asserted-by":"publisher","DOI":"10.1016\/j.tig.2014.01.004"},{"key":"2025120801384063000_2025.12.02.691925v1.17","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bts635"},{"key":"2025120801384063000_2025.12.02.691925v1.18","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bti525"},{"key":"2025120801384063000_2025.12.02.691925v1.19","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2009.97"},{"key":"2025120801384063000_2025.12.02.691925v1.20","doi-asserted-by":"publisher","DOI":"10.1038\/nature20149"},{"key":"2025120801384063000_2025.12.02.691925v1.21","doi-asserted-by":"publisher","DOI":"10.1016\/s0960-9822(02)01436-7"},{"key":"2025120801384063000_2025.12.02.691925v1.22","doi-asserted-by":"publisher","DOI":"10.1038\/s41576-019-0184-5"},{"key":"2025120801384063000_2025.12.02.691925v1.23","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.06.044"},{"key":"2025120801384063000_2025.12.02.691925v1.24","doi-asserted-by":"publisher","DOI":"10.1242\/dev.116996"},{"key":"2025120801384063000_2025.12.02.691925v1.25","doi-asserted-by":"publisher","DOI":"10.1007\/s004120050256"},{"key":"2025120801384063000_2025.12.02.691925v1.26","doi-asserted-by":"publisher","DOI":"10.1101\/sqb.2019.84.039347"},{"key":"2025120801384063000_2025.12.02.691925v1.27","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2010.02.002"},{"key":"2025120801384063000_2025.12.02.691925v1.28","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.10208"},{"key":"2025120801384063000_2025.12.02.691925v1.29","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0608155103"},{"key":"2025120801384063000_2025.12.02.691925v1.30","doi-asserted-by":"publisher","DOI":"10.1242\/dev.02245"},{"key":"2025120801384063000_2025.12.02.691925v1.31","doi-asserted-by":"publisher","DOI":"10.18632\/aging.205656"},{"key":"2025120801384063000_2025.12.02.691925v1.32","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-03-147967"},{"key":"2025120801384063000_2025.12.02.691925v1.33","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2208"},{"key":"2025120801384063000_2025.12.02.691925v1.34","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gku749"},{"key":"2025120801384063000_2025.12.02.691925v1.35","doi-asserted-by":"publisher","DOI":"10.1038\/s41597-023-02562-9"},{"key":"2025120801384063000_2025.12.02.691925v1.36","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2018.07.020"},{"key":"2025120801384063000_2025.12.02.691925v1.37","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp352"},{"key":"2025120801384063000_2025.12.02.691925v1.38","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-62205-y"},{"key":"2025120801384063000_2025.12.02.691925v1.39","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2014.01.021"},{"key":"2025120801384063000_2025.12.02.691925v1.40","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2004.08.017"},{"key":"2025120801384063000_2025.12.02.691925v1.41","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2020.04.009"},{"key":"2025120801384063000_2025.12.02.691925v1.42","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2235688100"},{"key":"2025120801384063000_2025.12.02.691925v1.43","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-7522-8_8"},{"key":"2025120801384063000_2025.12.02.691925v1.44","doi-asserted-by":"publisher","DOI":"10.1261\/rna.029454.111"},{"key":"2025120801384063000_2025.12.02.691925v1.45","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0706729105"},{"key":"2025120801384063000_2025.12.02.691925v1.46","doi-asserted-by":"publisher","DOI":"10.1007\/s40139-017-0153-7"},{"key":"2025120801384063000_2025.12.02.691925v1.47","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2010.12.044"},{"key":"2025120801384063000_2025.12.02.691925v1.48","doi-asserted-by":"publisher","DOI":"10.1242\/dev.068569"},{"key":"2025120801384063000_2025.12.02.691925v1.49","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.4150"},{"key":"2025120801384063000_2025.12.02.691925v1.50","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.4402"},{"key":"2025120801384063000_2025.12.02.691925v1.51","doi-asserted-by":"publisher","DOI":"10.1186\/s13072-021-00384-w"},{"key":"2025120801384063000_2025.12.02.691925v1.52","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gku365"},{"key":"2025120801384063000_2025.12.02.691925v1.53","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2016.05.005"},{"key":"2025120801384063000_2025.12.02.691925v1.54","doi-asserted-by":"publisher","DOI":"10.1186\/1471-213X-10-49"},{"key":"2025120801384063000_2025.12.02.691925v1.55","doi-asserted-by":"publisher","DOI":"10.1186\/1749-8104-6-32"},{"key":"2025120801384063000_2025.12.02.691925v1.56","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp616"},{"key":"2025120801384063000_2025.12.02.691925v1.57","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2004.03.039"},{"key":"2025120801384063000_2025.12.02.691925v1.58","doi-asserted-by":"publisher","DOI":"10.1002\/glia.24075"},{"key":"2025120801384063000_2025.12.02.691925v1.59","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagrm.2016.04.005"},{"key":"2025120801384063000_2025.12.02.691925v1.60","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20050559"},{"key":"2025120801384063000_2025.12.02.691925v1.61","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.01749"},{"key":"2025120801384063000_2025.12.02.691925v1.62","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3168"},{"key":"2025120801384063000_2025.12.02.691925v1.63","doi-asserted-by":"publisher","DOI":"10.1186\/s12915-021-01223-w"},{"key":"2025120801384063000_2025.12.02.691925v1.64","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1905675116"},{"key":"2025120801384063000_2025.12.02.691925v1.65","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15051454"},{"key":"2025120801384063000_2025.12.02.691925v1.66","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2021.06.005"},{"key":"2025120801384063000_2025.12.02.691925v1.67","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2021.02.031"},{"key":"2025120801384063000_2025.12.02.691925v1.68","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-020-00315-9"},{"key":"2025120801384063000_2025.12.02.691925v1.69","doi-asserted-by":"publisher","DOI":"10.1016\/j.cels.2019.04.004"},{"key":"2025120801384063000_2025.12.02.691925v1.70","doi-asserted-by":"publisher","DOI":"10.1016\/bs.pmbts.2015.06.006"},{"key":"2025120801384063000_2025.12.02.691925v1.71","doi-asserted-by":"publisher","DOI":"10.1002\/pro.4218"},{"key":"2025120801384063000_2025.12.02.691925v1.72","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2019.11.006"},{"key":"2025120801384063000_2025.12.02.691925v1.73","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.2859"},{"key":"2025120801384063000_2025.12.02.691925v1.74","doi-asserted-by":"publisher","DOI":"10.1038\/328131a0"},{"key":"2025120801384063000_2025.12.02.691925v1.75","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(90)90136-4"},{"key":"2025120801384063000_2025.12.02.691925v1.76","doi-asserted-by":"publisher","DOI":"10.1002\/embj.201386225"},{"key":"2025120801384063000_2025.12.02.691925v1.77","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-6988-3_15"},{"key":"2025120801384063000_2025.12.02.691925v1.78","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0116-13.2013"},{"key":"2025120801384063000_2025.12.02.691925v1.79","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.10.006"},{"key":"2025120801384063000_2025.12.02.691925v1.80","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0471-20.2020"},{"key":"2025120801384063000_2025.12.02.691925v1.81","doi-asserted-by":"publisher","DOI":"10.1242\/dev.02311"},{"key":"2025120801384063000_2025.12.02.691925v1.82","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2005.02.027"},{"key":"2025120801384063000_2025.12.02.691925v1.83","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-023-09354-w"},{"key":"2025120801384063000_2025.12.02.691925v1.84","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.17-21805"},{"key":"2025120801384063000_2025.12.02.691925v1.85","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2016.12.012"},{"key":"2025120801384063000_2025.12.02.691925v1.86","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e22307"},{"key":"2025120801384063000_2025.12.02.691925v1.87","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.92534.1"},{"key":"2025120801384063000_2025.12.02.691925v1.88","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-019-0375-9"}],"container-title":[],"original-title":[],"link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.64898\/2025.12.02.691925","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T12:49:44Z","timestamp":1765198184000},"score":1,"resource":{"primary":{"URL":"http:\/\/biorxiv.org\/lookup\/doi\/10.64898\/2025.12.02.691925"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,3]]},"references-count":88,"URL":"https:\/\/doi.org\/10.64898\/2025.12.02.691925","relation":{},"subject":[],"published":{"date-parts":[[2025,12,3]]},"subtype":"preprint"}}