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The nucleus accumbens (NAc) is a key brain region in the etiologies of these disorders and is actively modulated by CBD. Prior research has established that CBD alters the molecular composition of the NAc, but none have assessed how CBD affects NAc neuronal function. In this study, we demonstrate that CBD significantly decreases D1 and D2 medium spiny neuron membrane excitability, broadens action potentials, and has no effect on spontaneous excitatory synaptic transmission in the NAc core. These data enhance our understanding of CBD\u2019s physiological effects and provide mechanistic insight into its therapeutic potential.<\/jats:p>","DOI":"10.64898\/2025.12.02.691956","type":"posted-content","created":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T12:43:25Z","timestamp":1765197805000},"source":"Crossref","is-referenced-by-count":0,"title":["Cannabidiol Reduces D1 and D2 Medium Spiny Neuron Excitability in the Nucleus Accumbens Core"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-5576-4203","authenticated-orcid":false,"given":"Zev E.","family":"Jarrett","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4224-3866","authenticated-orcid":false,"given":"Brad 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