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Understanding the neuronal underpinnings of such cognitive resilience would propel the development of interventions for delaying dementia. To this end, we used cognitive testing to identify a subset of cognitively resilient 13-month-old TgF344-AD rats (established AD) and their non-transgenic littermates, followed by Neuropixels recording from 8500 neurons during repeated somatosensory stimulation. Cognitively resilient TgF344-AD rats recruited fewer neurons yet displayed more stable neuronal representations during repeated stimulations in cortical excitatory and hippocampal inhibitory ensembles, with reduced excitatory spike burstiness during network activation and a distinct pattern of functional synaptic connectivity. These associations existed independently of amyloid and tau levels. For the first time, our study revealed neuronal population-level hallmarks of maintained cognition that may serve as a novel neurophysiological biomarker of cognitive resilience and a target for stabilizing cognition.<\/jats:p>","DOI":"10.64898\/2025.12.05.692431","type":"posted-content","created":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T08:05:46Z","timestamp":1765353946000},"source":"Crossref","is-referenced-by-count":3,"title":["Stable neuronal representations to repeated stimulation underlie cognitive resilience in Alzheimer\u2019s disease pathology"],"prefix":"10.64898","author":[{"given":"Keying","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Pineau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Koletar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Trevisiol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack Simiao","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Hill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maged","family":"Goubran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Sled","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JoAnne","family":"McLaurin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bojana","family":"Stefanovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2025121113500984000_2025.12.05.692431v1.1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-019-0333-5"},{"key":"2025121113500984000_2025.12.05.692431v1.2","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a006189"},{"key":"2025121113500984000_2025.12.05.692431v1.3","doi-asserted-by":"publisher","DOI":"10.1097\/NEN.0b013e31825018f7"},{"key":"2025121113500984000_2025.12.05.692431v1.4","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-022-00642-9"},{"key":"2025121113500984000_2025.12.05.692431v1.5","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.65.11.1509"},{"key":"2025121113500984000_2025.12.05.692431v1.6","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.22828"},{"key":"2025121113500984000_2025.12.05.692431v1.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2022.02.005"},{"key":"2025121113500984000_2025.12.05.692431v1.8","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2019.101002"},{"key":"2025121113500984000_2025.12.05.692431v1.9","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s13024-024-00719-7","article-title":"The concept of resilience to Alzheimer\u2019s Disease: current definitions and cellular and molecular mechanisms","volume":"19","year":"2024","journal-title":"Mol. 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