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Most studies to date have relied on one or a few mouse models of infection, limiting insights into pathogen-specific neuroimmune interactions that generate sickness. We hypothesized that different pathogens might elicit distinct sickness states by engaging different cell types and brain circuits. Using inflammatory models representing bacterial, viral, allergic, parasitic or colitis conditions, we assessed sickness across scales: organismal \u2013 behavior and physiology; cellular \u2013 brain-wide neural activity; and molecular \u2013 single-cell\n                  <jats:italic>in situ<\/jats:italic>\n                  transcriptomics in hypothalamus areas associated with social and homeostatic functions affected during sickness. Remarkably, immune challenges elicited unique repertoires of changes across all scales. Our findings reveal pathogen-specific sickness states encoded by the brain across scales, thereby broadening our understanding of how infections make us sick.\n                <\/jats:p>","DOI":"10.64898\/2025.12.06.692770","type":"posted-content","created":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T18:45:15Z","timestamp":1765219515000},"source":"Crossref","is-referenced-by-count":2,"title":["Brain-immune interactions generate pathogen-specific sickness states"],"prefix":"10.64898","author":[{"given":"Zuri A.","family":"Sullivan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertrand J.","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikrant","family":"Kapoor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula 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