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Since human and mouse studies demonstrate progressive striatal vulnerability in SCA1, we examined age-dependent molecular, cellular and functional striatal attributes in SCA1\n                  <jats:italic>\n                    (f-ATXN1\n                    <jats:sup>146Q\/2Q<\/jats:sup>\n                    )\n                  <\/jats:italic>\n                  knockin mice, by assessing RNA-sequencing, immunohistochemistry and electrophysiology. Striatal mRNAs are downregulated in SCA1 mice, many in common with HD mice, and specificity in MSNs is supported by the rescue of transcriptomic dysregulation with deletion of mutant\n                  <jats:italic>Ataxin1<\/jats:italic>\n                  from MSNs. Immunohistochemistry assessed dopamine receptor 1 (D1R) and 2 (D2R) expression in indirect and direct MSNs. In HD mice (\n                  <jats:italic>\n                    Htt\n                    <jats:sup>Q175\/Q7<\/jats:sup>\n                  <\/jats:italic>\n                  ), expression of both D1R and D2R proteins in MSNs decreased with age in parallel with their RNA levels. In the SCA1 mouse striatum, D1R protein expression decreased with age as seen in murine HD striatum. In contrast, while D2R protein level was decreased similar to D1R protein at 5-weeks of age, by 40-weeks expression of D2R protein recovered to levels recorded in WT mice. Electrophysiological assessment showed a reduction of excitatory synaptic transmission in SCA1 mouse MSNs, indicating functional deficits early in disease. In contrast to cerebellar and many other aspects of SCA1 pathology known to depend on proper nuclear localization of ATXN1 with an expanded polyglutamine, mutating ATXN1\u2019s nuclear localization failed to correct striatal MSN RNA and protein downregulations, indicating a difference in how ATXN1 exerts its pathological effects between the cerebellum and the striatum. Together, these data provide a molecular and cellular basis of striatal pathology in SCA1.\n                <\/jats:p>","DOI":"10.64898\/2025.12.11.693749","type":"posted-content","created":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T10:10:17Z","timestamp":1765707017000},"source":"Crossref","is-referenced-by-count":0,"title":["Striatal pathology in Spinocerebellar Ataxia Type 1 mice: A comparative study with Huntington\u2019s disease"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6348-4909","authenticated-orcid":false,"given":"Pragya","family":"Goel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4094-9435","authenticated-orcid":false,"given":"Praseuth","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-1453-4400","authenticated-orcid":false,"given":"Lisa","family":"Duvick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7402-2366","authenticated-orcid":false,"given":"Orion","family":"Rainwater","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shannah","family":"Serres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0800-5856","authenticated-orcid":false,"given":"Brennon","family":"O\u2019Callaghan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1136-5462","authenticated-orcid":false,"given":"Rocio","family":"Gomez-Pastor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5791-8285","authenticated-orcid":false,"given":"Mustafa","family":"Mehkary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7314-7658","authenticated-orcid":false,"given":"Terence","family":"Gall-Duncan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3418-4146","authenticated-orcid":false,"given":"Peter","family":"Langfelder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3705-7935","authenticated-orcid":false,"given":"X. 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