{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T15:18:59Z","timestamp":1785424739519,"version":"3.56.0"},"posted":{"date-parts":[[2025,12,13]]},"group-title":"Neuroscience","reference-count":114,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T00:00:00Z","timestamp":1765584000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"award":["R01NS125018"],"award-info":[{"award-number":["R01NS125018"]}],"id":[{"id":"https:\/\/ror.org\/001d55x84","id-type":"ROR","asserted-by":"publisher"}]},{"award":["R35 GM145279"],"award-info":[{"award-number":["R35 GM145279"]}],"id":[{"id":"https:\/\/ror.org\/001d55x84","id-type":"ROR","asserted-by":"publisher"}]},{"award":["R01AA030604"],"award-info":[{"award-number":["R01AA030604"]}],"id":[{"id":"https:\/\/ror.org\/001d55x84","id-type":"ROR","asserted-by":"publisher"}]},{"award":["R35 GM131765"],"award-info":[{"award-number":["R35 GM131765"]}],"id":[{"id":"https:\/\/ror.org\/001d55x84","id-type":"ROR","asserted-by":"publisher"}]},{"award":["R01 NS136686"],"award-info":[{"award-number":["R01 NS136686"]}],"id":[{"id":"https:\/\/ror.org\/001d55x84","id-type":"ROR","asserted-by":"publisher"}]},{"award":["R01 NS118179"],"award-info":[{"award-number":["R01 NS118179"]}],"id":[{"id":"https:\/\/ror.org\/001d55x84","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2025,12,16]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                <jats:p>\n                  Recent studies have revealed many alternative exons differentially spliced across diverse neuron types in the mammalian brain, but their links to neuronal physiology remain unclear. Here we characterize a deeply conserved microexon E35a in\n                  <jats:italic>Ank3<\/jats:italic>\n                  encoding ankyrin-G (AnkG), a multifaceted adaptor protein best known as a master organizer of the axon initial segment (AIS) and as a leading genetic risk factor for bipolar disorder. E35a is predominantly skipped in cortical glutamatergic neurons but included in cortical GABAergic neurons and cerebellar neurons, which is dictated by multiple neuronal splicing factors. In E35a-deletion mice we generated, interneurons show increased excitability and somatic Ca\n                  <jats:sup>2+<\/jats:sup>\n                  activity, without disruption in AIS. Biochemical analyses suggest that E35a inclusion facilitates AnkG interaction with a protein complex involving inositol trisphosphate receptors (InsP3Rs) important for intracellular Ca\n                  <jats:sup>2+<\/jats:sup>\n                  signaling. Alternative splicing therefore allows AnkG to modulate neuron type-specific excitability in addition to its ubiquitous pan-neuronal role in organizing the AIS.\n                <\/jats:p>","DOI":"10.64898\/2025.12.12.693948","type":"posted-content","created":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T09:45:12Z","timestamp":1765619112000},"source":"Crossref","is-referenced-by-count":0,"title":["A neuron type-specific microexon in\n                  <i>Ank3<\/i>\n                  \/ankyrin-G modulates calcium activity and neuronal excitability"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5806-5603","authenticated-orcid":false,"given":"Shah","family":"Alam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgia","family":"Dermentzaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Cabrera-Garcia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruizhi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Campbell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria","family":"Balbo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brittany L.","family":"Phillips","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Estrada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianna","family":"Zazhytska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yow-Tyng","family":"Yeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lia","family":"Min","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Rafikian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Valenzuela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Joseph","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tulsi","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dmytro","family":"Ustienenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helene","family":"Lovett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huijuan","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Brenner-Morton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chyuan-Sheng","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clarissa L.","family":"Waites","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hynek","family":"Wichterle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lizhen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edmund","family":"Au","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marko","family":"Jovanovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stavros","family":"Lomvardas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul M.","family":"Jenkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng-Han","family":"Kuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3488-0670","authenticated-orcid":false,"given":"Yueqing","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil L.","family":"Harrison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaolin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2025121712111190000_2025.12.12.693948v2.1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1618"},{"key":"2025121712111190000_2025.12.12.693948v2.2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3444"},{"key":"2025121712111190000_2025.12.12.693948v2.3","doi-asserted-by":"publisher","DOI":"10.1038\/nature08909"},{"key":"2025121712111190000_2025.12.12.693948v2.4","doi-asserted-by":"publisher","DOI":"10.1038\/nature07509"},{"key":"2025121712111190000_2025.12.12.693948v2.5","doi-asserted-by":"publisher","DOI":"10.1038\/ng.259"},{"key":"2025121712111190000_2025.12.12.693948v2.6","doi-asserted-by":"publisher","DOI":"10.1038\/ng.264"},{"key":"2025121712111190000_2025.12.12.693948v2.7","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1502849112"},{"key":"2025121712111190000_2025.12.12.693948v2.8","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1860-14.2014"},{"key":"2025121712111190000_2025.12.12.693948v2.9","doi-asserted-by":"crossref","unstructured":"Weyn-Vanhentenryck, S.M. et al. Precise temporal regulation of alternative splicing during neural development. Nat Commun, 2189 (2018).","DOI":"10.1101\/247601"},{"key":"2025121712111190000_2025.12.12.693948v2.10","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-019-0465-5"},{"key":"2025121712111190000_2025.12.12.693948v2.11","unstructured":"Huntley, M.A. et al. Genome-wide analysis of differential gene expression and splicing in excitatory neurons and interneuron subtypes. J Neurosci, 1615\u20131619 (2019)."},{"key":"2025121712111190000_2025.12.12.693948v2.12","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2013056118"},{"key":"2025121712111190000_2025.12.12.693948v2.13","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.11.035"},{"key":"2025121712111190000_2025.12.12.693948v2.14","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkt216"},{"key":"2025121712111190000_2025.12.12.693948v2.15","doi-asserted-by":"crossref","unstructured":"Nguyen, T.M. et al. An alternative splicing switch shapes neurexin repertoires in principal neurons versus interneurons in the mouse hippocampus. Elife 5 (2016).","DOI":"10.7554\/eLife.22757"},{"key":"2025121712111190000_2025.12.12.693948v2.16","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.11.028"},{"key":"2025121712111190000_2025.12.12.693948v2.17","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(02)00683-9"},{"key":"2025121712111190000_2025.12.12.693948v2.18","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2014.05.004"},{"key":"2025121712111190000_2025.12.12.693948v2.19","doi-asserted-by":"publisher","DOI":"10.1080\/19336950.2022.2120467"},{"key":"2025121712111190000_2025.12.12.693948v2.20","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a003012"},{"key":"2025121712111190000_2025.12.12.693948v2.21","doi-asserted-by":"publisher","DOI":"10.1038\/ng.209"},{"key":"2025121712111190000_2025.12.12.693948v2.22","doi-asserted-by":"publisher","DOI":"10.1038\/ng.940"},{"key":"2025121712111190000_2025.12.12.693948v2.23","doi-asserted-by":"publisher","DOI":"10.1186\/s13229-015-0017-0"},{"key":"2025121712111190000_2025.12.12.693948v2.24","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2008.134"},{"key":"2025121712111190000_2025.12.12.693948v2.25","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200806112"},{"key":"2025121712111190000_2025.12.12.693948v2.26","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2852"},{"key":"2025121712111190000_2025.12.12.693948v2.27","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1922-17.2018"},{"key":"2025121712111190000_2025.12.12.693948v2.28","doi-asserted-by":"publisher","DOI":"10.1038\/nn2040"},{"key":"2025121712111190000_2025.12.12.693948v2.29","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.143.5.1295"},{"key":"2025121712111190000_2025.12.12.693948v2.30","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200109026"},{"key":"2025121712111190000_2025.12.12.693948v2.31","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2005.04.013"},{"key":"2025121712111190000_2025.12.12.693948v2.32","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1416544112"},{"key":"2025121712111190000_2025.12.12.693948v2.33","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2018.01.020"},{"key":"2025121712111190000_2025.12.12.693948v2.34","doi-asserted-by":"crossref","unstructured":"Darwish, M. , et al. Activity-regulated micro-exon splicing programs underlie late-onset plasticity at the axon initial segment. bioRxiv (2023).","DOI":"10.1101\/2023.10.29.564567"},{"key":"2025121712111190000_2025.12.12.693948v2.35","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0654-5"},{"key":"2025121712111190000_2025.12.12.693948v2.36","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4216"},{"key":"2025121712111190000_2025.12.12.693948v2.37","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1200613109"},{"key":"2025121712111190000_2025.12.12.693948v2.38","doi-asserted-by":"publisher","DOI":"10.1038\/S41586-024-07487-W"},{"key":"2025121712111190000_2025.12.12.693948v2.39","doi-asserted-by":"publisher","DOI":"10.1038\/nature01335"},{"key":"2025121712111190000_2025.12.12.693948v2.40","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0030423"},{"key":"2025121712111190000_2025.12.12.693948v2.41","doi-asserted-by":"publisher","DOI":"10.1101\/gad.256115.114"},{"key":"2025121712111190000_2025.12.12.693948v2.42","doi-asserted-by":"publisher","DOI":"10.1101\/gr.220962.117"},{"key":"2025121712111190000_2025.12.12.693948v2.43","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2016.11.033"},{"key":"2025121712111190000_2025.12.12.693948v2.44","doi-asserted-by":"publisher","DOI":"10.1038\/nature20111"},{"key":"2025121712111190000_2025.12.12.693948v2.45","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2016.233"},{"key":"2025121712111190000_2025.12.12.693948v2.46","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2022.05.022)"},{"key":"2025121712111190000_2025.12.12.693948v2.47","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2021.03.035"},{"key":"2025121712111190000_2025.12.12.693948v2.48","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1519"},{"key":"2025121712111190000_2025.12.12.693948v2.49","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2016.06.033"},{"key":"2025121712111190000_2025.12.12.693948v2.50","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-019-0417-0"},{"key":"2025121712111190000_2025.12.12.693948v2.51","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.15-04-02638.1995"},{"key":"2025121712111190000_2025.12.12.693948v2.52","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(90)90185-D"},{"key":"2025121712111190000_2025.12.12.693948v2.53","doi-asserted-by":"publisher","DOI":"10.1126\/science.1255263"},{"key":"2025121712111190000_2025.12.12.693948v2.54","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2008.03.003"},{"key":"2025121712111190000_2025.12.12.693948v2.55","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.01.007"},{"key":"2025121712111190000_2025.12.12.693948v2.56","doi-asserted-by":"crossref","unstructured":"Goethals, S. & Brette, R . Theoretical relation between axon initial segment geometry and excitability. Elife 9 (2020).","DOI":"10.7554\/eLife.53432"},{"key":"2025121712111190000_2025.12.12.693948v2.57","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1038\/s41467-024-45035-2","article-title":"A mesocortical glutamatergic pathway modulates neuropathic pain independent of dopamine co-release","volume":"15","year":"2024","journal-title":"Nat Commun"},{"key":"2025121712111190000_2025.12.12.693948v2.58","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-022-01250-y"},{"key":"2025121712111190000_2025.12.12.693948v2.59","doi-asserted-by":"publisher","DOI":"10.1002\/cne.22733"},{"key":"2025121712111190000_2025.12.12.693948v2.60","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00035.2006"},{"key":"2025121712111190000_2025.12.12.693948v2.61","doi-asserted-by":"crossref","unstructured":"Mikoshiba, K . The IP3 receptor\/Ca2+ channel and its cellular function. Biochem Soc Symp, 9\u201322 (2007).","DOI":"10.1042\/BSS2007c02"},{"key":"2025121712111190000_2025.12.12.693948v2.62","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2004.10.003"},{"key":"2025121712111190000_2025.12.12.693948v2.63","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.20220147"},{"key":"2025121712111190000_2025.12.12.693948v2.64","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2023.10.024"},{"key":"2025121712111190000_2025.12.12.693948v2.65","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3325-16.2017"},{"key":"2025121712111190000_2025.12.12.693948v2.66","doi-asserted-by":"publisher","DOI":"10.1038\/srep28137"},{"key":"2025121712111190000_2025.12.12.693948v2.67","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80510-3"},{"key":"2025121712111190000_2025.12.12.693948v2.68","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2008.08.019"},{"key":"2025121712111190000_2025.12.12.693948v2.69","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.02.011"},{"key":"2025121712111190000_2025.12.12.693948v2.70","doi-asserted-by":"publisher","DOI":"10.1038\/35036035"},{"key":"2025121712111190000_2025.12.12.693948v2.71","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1987.sp016517"},{"key":"2025121712111190000_2025.12.12.693948v2.72","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2003.049072"},{"key":"2025121712111190000_2025.12.12.693948v2.73","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2006.126367"},{"key":"2025121712111190000_2025.12.12.693948v2.74","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1999.82.5.2476"},{"key":"2025121712111190000_2025.12.12.693948v2.75","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(00)01892-0"},{"key":"2025121712111190000_2025.12.12.693948v2.76","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-06-02058.2003"},{"key":"2025121712111190000_2025.12.12.693948v2.77","doi-asserted-by":"crossref","unstructured":"Benedetti, L. et al. Periodic ER-plasma membrane junctions support long-range Ca(2+) signal integration in dendrites. Cell (2024).","DOI":"10.1101\/2024.05.27.596121"},{"key":"2025121712111190000_2025.12.12.693948v2.78","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.37.23952"},{"key":"2025121712111190000_2025.12.12.693948v2.79","doi-asserted-by":"crossref","first-page":"17252","DOI":"10.1016\/S0021-9258(17)44896-4","article-title":"The anion exchanger and Na+K(+)-ATPase interact with distinct sites on ankyrin in in vitro assays","volume":"265","year":"1990","journal-title":"J Biol Chem"},{"key":"2025121712111190000_2025.12.12.693948v2.80","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2014.10.010"},{"key":"2025121712111190000_2025.12.12.693948v2.81","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-018-0308-x"},{"key":"2025121712111190000_2025.12.12.693948v2.82","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1417989112"},{"key":"2025121712111190000_2025.12.12.693948v2.83","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3858"},{"key":"2025121712111190000_2025.12.12.693948v2.84","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2021.06.052"},{"key":"2025121712111190000_2025.12.12.693948v2.85","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4070"},{"key":"2025121712111190000_2025.12.12.693948v2.86","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-44798-9"},{"key":"2025121712111190000_2025.12.12.693948v2.87","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.11.022"},{"key":"2025121712111190000_2025.12.12.693948v2.88","doi-asserted-by":"publisher","DOI":"10.1038\/srep18178"},{"key":"2025121712111190000_2025.12.12.693948v2.89","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2014.00087"},{"key":"2025121712111190000_2025.12.12.693948v2.90","doi-asserted-by":"publisher","DOI":"10.1016\/j.gdata.2015.05.022"},{"key":"2025121712111190000_2025.12.12.693948v2.91","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2017.00304"},{"key":"2025121712111190000_2025.12.12.693948v2.92","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.11613"},{"key":"2025121712111190000_2025.12.12.693948v2.93","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2016.05.023"},{"key":"2025121712111190000_2025.12.12.693948v2.94","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0053575"},{"key":"2025121712111190000_2025.12.12.693948v2.95","doi-asserted-by":"publisher","DOI":"10.1038\/nature10532"},{"key":"2025121712111190000_2025.12.12.693948v2.96","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaz1776"},{"key":"2025121712111190000_2025.12.12.693948v2.97","unstructured":"Li, M. et al. Integrative functional genomic analysis of human brain development and neuropsychiatric risks. Science 362 (2018)."},{"key":"2025121712111190000_2025.12.12.693948v2.98","doi-asserted-by":"crossref","first-page":"35","DOI":"10.12688\/f1000research.2-35.v1","article-title":"Longitudinal RNA sequencing of the deep transcriptome during neurogenesis of cortical glutamatergic neurons from murine ESCs","volume":"2","year":"2013","journal-title":"F1000Res"},{"key":"2025121712111190000_2025.12.12.693948v2.99","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.01201"},{"key":"2025121712111190000_2025.12.12.693948v2.100","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1909989116"},{"key":"2025121712111190000_2025.12.12.693948v2.101","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2089"},{"key":"2025121712111190000_2025.12.12.693948v2.102","doi-asserted-by":"publisher","DOI":"10.1109\/TIP.2008.924393"},{"key":"2025121712111190000_2025.12.12.693948v2.103","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2006.356"},{"key":"2025121712111190000_2025.12.12.693948v2.104","doi-asserted-by":"publisher","DOI":"10.1101\/pdb.prot068247"},{"key":"2025121712111190000_2025.12.12.693948v2.105","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2017.12.039"},{"key":"2025121712111190000_2025.12.12.693948v2.106","unstructured":"Paxinos, G. & Franklin, K. The mouse brain in stereotaxic coordinates, Edn. Compact 2nd. (Elsevier Academic Press, Amsterdam; Boston, 2004)."},{"key":"2025121712111190000_2025.12.12.693948v2.107","doi-asserted-by":"crossref","first-page":"108501","DOI":"10.1016\/j.neuropharm.2021.108501","article-title":"Alcohol reduces the activity of somatostatin interneurons in the mouse prefrontal cortex: A neural basis for its disinhibitory effect?","volume":"188","year":"2021","journal-title":"Neuropharmacology"},{"key":"2025121712111190000_2025.12.12.693948v2.108","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.111333"},{"key":"2025121712111190000_2025.12.12.693948v2.109","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-62703-411-1_3"},{"key":"2025121712111190000_2025.12.12.693948v2.110","doi-asserted-by":"crossref","first-page":"343","DOI":"10.3389\/fncel.2017.00343","article-title":"Motor deficits and cerebellar atrophy in Elovl5 knock out mice","volume":"11","year":"2017","journal-title":"Front Cell Neurosci"},{"key":"2025121712111190000_2025.12.12.693948v2.111","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.6107-11.2012"},{"key":"2025121712111190000_2025.12.12.693948v2.112","doi-asserted-by":"publisher","DOI":"10.1016\/j.npep.2007.02.002"},{"key":"2025121712111190000_2025.12.12.693948v2.113","doi-asserted-by":"crossref","first-page":"634157","DOI":"10.3389\/fnbeh.2021.634157","article-title":"Marked mild cognitive deficits in humanized mouse model of Alzheimer\u2019s-type tau pathology","volume":"15","year":"2021","journal-title":"Front Behav Neurosci"},{"key":"2025121712111190000_2025.12.12.693948v2.114","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1038\/s42003-021-02841-4","article-title":"Astrocytic ApoE underlies maturation of hippocampal neurons and cognitive recovery after traumatic brain injury in mice","volume":"4","year":"2021","journal-title":"Commun Biol"}],"container-title":[],"original-title":[],"link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.64898\/2025.12.12.693948","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T05:06:51Z","timestamp":1782277611000},"score":1,"resource":{"primary":{"URL":"http:\/\/biorxiv.org\/lookup\/doi\/10.64898\/2025.12.12.693948"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,13]]},"references-count":114,"URL":"https:\/\/doi.org\/10.64898\/2025.12.12.693948","relation":{"is-preprint-of":[{"id-type":"doi","id":"10.1038\/s41467-026-69486-x","asserted-by":"subject"}]},"subject":[],"published":{"date-parts":[[2025,12,13]]},"subtype":"preprint"}}