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These genes, spanning multiple proteostasis pathways, were differentially expressed in\n                    <jats:italic>MAPT<\/jats:italic>\n                    mutant neurons and dysregulated in FTD and AD brains.\n                    <jats:italic>NINL,<\/jats:italic>\n                    which encodes Nlp, emerged as the only gene consistently upregulated across all datasets.\n                    <jats:italic>NINL<\/jats:italic>\n                    overexpression reduced tau seeding and enhanced lysosomal proteolytic activity, whereas two FTD-enriched\n                    <jats:italic>NINL<\/jats:italic>\n                    frameshift variants impaired Nlp expression and abolished these protective effects.\n                  <\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Discussion<\/jats:title>\n                  <jats:p>\n                    Our findings identify a set of proteostasis genes with genetic and transcriptional links to neurodegeneration and reveal\n                    <jats:italic>NINL<\/jats:italic>\n                    as a novel regulator of tau aggregation, potentially upregulated as an adaptive response to proteotoxic stress.\n                  <\/jats:p>\n                <\/jats:sec>","DOI":"10.64898\/2025.12.12.694063","type":"posted-content","created":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T23:00:16Z","timestamp":1765926016000},"source":"Crossref","is-referenced-by-count":0,"title":["Integrative Genomic and Functional Analyses Reveal NINL as a Modulator of Tau Aggregation"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5618-7578","authenticated-orcid":false,"given":"Samantha K.","family":"Swift","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangming","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9852-5504","authenticated-orcid":false,"given":"J. 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