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We implemented a non-invasive focal Transcranial Ultrasound Stimulation (TUS) approach with known longer-lasting post-stimulation effects in two rhesus macaques performing a novel context-dependent memory-sequencing task implemented on multiple touchscreens within their home units. Consistently in both monkeys, TUS to the anterior, but not posterior, medial temporal lobe enhanced performance under stable memory-sequencing contexts. TUS to the medial prefrontal cortex, on the other hand, selectively improved performance when contexts were unstable and the monkey needed to adapt to both a change in context and temporal sequence. These findings provide positive causal evidence of a functional dissociation within fronto-temporal memory circuits and pave the way for advancing non-invasive approaches to improve cognitive function and the study of neural circuits under focal enhancement across species.<\/jats:p>\n                <jats:sec>\n                  <jats:title>IMPACT STATEMENT<\/jats:title>\n                  <jats:p>Transcranial ultrasound stimulation of the prefrontal-hippocampal network selectively enhances context-guided memory in macaques, demonstrating that non-invasive brain stimulation can causally improve, rather than only disrupt, memory circuits.<\/jats:p>\n                <\/jats:sec>","DOI":"10.64898\/2025.12.19.695543","type":"posted-content","created":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T01:35:24Z","timestamp":1766453724000},"source":"Crossref","is-referenced-by-count":0,"title":["Selective enhancement of fronto-temporal mechanisms for adaptive 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