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This cross-sectional study analyzed data from 55 youth with current depression (M\n                  <jats:sub>age<\/jats:sub>\n                  =21.4 years; Female=75%). Plasma was assayed for relative quantification of 92 immune proteins, followed by dimensionality reduction via principal component (PC) analysis, forming five PC scores. Dopamine availability was indexed by basal ganglia tissue iron, quantified by MRI R2\u2019, a measure detectable in youth. Anhedonia was assessed using the Snaith\u2013Hamilton Pleasure Scale (SHAPS), thought to capture overall anhedonia, and Positive Valence Systems Scale (PVSS), which provides overall, anticipatory, and consummatory anhedonia scores. PC1 scores\u2014whose loadings indicated broad inflammatory activity, including cytokines, chemokines, and tissue remodeling\/angiogenic markers\u2014moderated the relationship between basal ganglia dopamine availability and anhedonia: At higher PC1 levels, lower dopamine availability was linked to greater overall anhedonia (as measured by SHAPS) and anticipatory anhedonia, but not to consummatory anhedonia. Exploratory analyses showed comparable effect patterns for PC4, reflecting T cell-related effector\/apoptotic signaling. Analyses of individual basal ganglia regions suggest potential differences in dopaminergic-immune interactions across these regions, with effects most consistently observed in the putamen. Findings highlight nuanced neuroimmune pathways underlying anhedonia components in youth and support inflammation-based models of depression emphasizing dopaminergic-immune interplay.\n                <\/jats:p>","DOI":"10.64898\/2025.12.23.696320","type":"posted-content","created":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T09:55:14Z","timestamp":1766570114000},"source":"Crossref","is-referenced-by-count":0,"title":["Basal Ganglia Dopamine Availability and Immune Activation Interact and Relate to Anhedonia Severity among Youth with Depression"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2448-5877","authenticated-orcid":false,"given":"Iris Ka-Yi","family":"Chat","sequence":"first","affiliation":[{"name":"Department of Psychology, University of California, Los Angeles, Los Angeles, CA, USA"},{"name":"Department of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6286-1242","authenticated-orcid":false,"given":"James W.","family":"Murrough","sequence":"additional","affiliation":[{"name":"Depression and Anxiety Center for Discovery and Treatment, Department of Psychiatry, Icahn School of Medicine of Mount Sinai, New York, NY, USA"},{"name":"Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA"},{"name":"VISN 2 Mental Illness Research, Education, and Clinical Center (MIRECC), James J. 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