{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T19:25:25Z","timestamp":1793906725903,"version":"4.8.0"},"posted":{"date-parts":[[2025,12,29]]},"group-title":"Genetic and Genomic Medicine","reference-count":26,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T00:00:00Z","timestamp":1766966400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2025,12,31]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Large-scale sequencing initiatives have generated extensive genomic resources essential for variant interpretation, yet their effective use often requires bioinformatics expertise. To support identification of Parkinson\u2019s disease (PD) risk and disease-causing variants, we developed an open-access, summary-level genomic data browser.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We performed uniform joint variant calling to harmonize whole-genome sequencing (WGS) data from AMP-PD Release 4, GP2 Data Releases, and additional controls from the Alzheimer\u2019s Disease Sequencing Project. Clinical exome sequencing (CES) data from GP2 Release 8 was also included.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The integrated dataset includes 31,665 WGS and 9,559 CES samples, spanning eleven ancestries and over 300 million variants.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>\n                    The GP2 Genome Browser is a lightweight, flexible platform providing intuitive gene- and variant-level summaries with ancestry-stratified allele frequencies and functional annotations. It is open source and freely accessible at\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/gp2.broadinstitute.org\">https:\/\/gp2.broadinstitute.org<\/jats:ext-link>\n                    , enabling broad access to PD genomic data and supporting global research efforts.\n                  <\/jats:p>\n                <\/jats:sec>","DOI":"10.64898\/2025.12.29.25343143","type":"posted-content","created":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T02:15:10Z","timestamp":1767060910000},"source":"Crossref","is-referenced-by-count":3,"title":["The Global Parkinson\u2019s Disease Genetics (GP2) Genome Browser"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0225-8772","authenticated-orcid":false,"given":"Zih-Hua","family":"Fang","sequence":"first","affiliation":[{"name":"DataTecnica, Washington, DC, USA"},{"name":"German Center for Neurodegenerative Disease (DZNE), T\u00fcbingen, 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Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha","family":"Hong","sequence":"additional","affiliation":[{"name":"Center for Alzheimer\u2019s and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2390-8110","authenticated-orcid":false,"given":"Hampton L.","family":"Leonard","sequence":"additional","affiliation":[{"name":"DataTecnica, Washington, DC, USA"},{"name":"Center for Alzheimer\u2019s and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7978-1051","authenticated-orcid":false,"given":"Mary 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