{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T18:56:54Z","timestamp":1790621814301,"version":"4.1.0"},"posted":{"date-parts":[[2025,12,31]]},"group-title":"Cancer Biology","reference-count":68,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T00:00:00Z","timestamp":1767139200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the Prostate Cancer Research Program Early Investigator Research Award","award":["W81XWH-21-PCRP-EIRA"],"award-info":[{"award-number":["W81XWH-21-PCRP-EIRA"]}]},{"DOI":"10.13039\/100000011","name":"HHMI","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000011","id-type":"DOI","asserted-by":"crossref"}]},{"name":"NCI","award":["P30 CA08748"],"award-info":[{"award-number":["P30 CA08748"]}]},{"name":"NCI","award":["P01CA298991"],"award-info":[{"award-number":["P01CA298991"]}]},{"name":"NCI","award":["P50CA097186"],"award-info":[{"award-number":["P50CA097186"]}]},{"name":"NIH","award":["CA193837"],"award-info":[{"award-number":["CA193837"]}]},{"name":"NIH","award":["CA092629"],"award-info":[{"award-number":["CA092629"]}]},{"name":"NIH","award":["CA265768"],"award-info":[{"award-number":["CA265768"]}]},{"name":"NIH","award":["CA008748"],"award-info":[{"award-number":["CA008748"]}]},{"DOI":"10.13039\/100032631","name":"Calico Life Sciences","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100032631","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,8,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>\n                  Treatment-related neuroendocrine prostate cancer (NEPC) is an increasingly frequent mechanism of resistance to androgen receptor pathway inhibitor (ARPI) therapy in prostate adenocarcinoma (PRAD). This lineage transition is dependent on upregulation of the NE-specifying transcription factor ASCL1, typically in a genetic background of\n                  <jats:italic>RB1<\/jats:italic>\n                  and\n                  <jats:italic>TP53<\/jats:italic>\n                  loss. Here we identify extracellular matrix-integrin-YAP1\/TEAD signaling as a critical brake on NEPC lineage transition. Deletion of\n                  <jats:italic>Itgb1<\/jats:italic>\n                  , the shared B1 subunit required for collagen and laminin-mediated integrin activation, is sufficient to induce ASCL1 and NE lineage gene expression, by activating LATS1\/2 kinases with subsequent inactivation of YAP1\/TEAD signaling. Conversely, restoration of YAP1\/TEAD signaling by pharmacological LATS1\/2 inhibition, or by expression of constitutively active YAP1\/TAZ mutants, prevents or reverts NEPC lineage transition. NOTCH and AR cooperate with YAP\/TEAD to repress ASCL1, such that combined inhibition leads to complete reprogramming of PRAD into NEPC\n                  <jats:italic>in vitro<\/jats:italic>\n                  , providing a dynamic platform to dissect the molecular events responsible for lineage transition over time. We find that lineage transition is accompanied by a redistribution of FOXA1 and TEAD cistromes from PRAD to NEPC-specific enhancers and requires the pioneering activity of FOXA1. Thus, extracellular matrix\/integrin signaling in the PRAD tumor microenvironment restrains NE lineage plasticity, highlighting a potential path for pharmacological inhibitors in modulating treatment-induced lineage change.\n                <\/jats:p>","DOI":"10.64898\/2025.12.30.697072","type":"posted-content","created":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T16:45:18Z","timestamp":1767199518000},"source":"Crossref","is-referenced-by-count":4,"title":["Extracellular matrix regulates lineage plasticity in prostate cancer through YAP\/TEAD"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8500-7652","authenticated-orcid":false,"given":"Teng","family":"Han","sequence":"first","affiliation":[{"name":"Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Sun","sequence":"additional","affiliation":[{"name":"Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Lange","sequence":"additional","affiliation":[{"name":"Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y Zoe","family":"Cho","sequence":"additional","affiliation":[{"name":"Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Mcgillivray","sequence":"additional","affiliation":[{"name":"Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA"},{"name":"Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maren","family":"B\u00fcttner","sequence":"additional","affiliation":[{"name":"Calico Life Sciences LLC, South San Francisco, CA 94080, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathaniel R","family":"Kastan","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience, The Rockefeller University, New York, NY 10021, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subhiksha","family":"Nandakumar","sequence":"additional","affiliation":[{"name":"Marie-Jos\u00e9e and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA"},{"name":"Computational Oncology Service, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA"},{"name":"The Halvorsen Center for Computational Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiyong","family":"Zhao","sequence":"additional","affiliation":[{"name":"Antitumor Assessment Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eralda","family":"Salataj","sequence":"additional","affiliation":[{"name":"Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanyukta","family":"Oak","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience, The Rockefeller University, New York, NY 10021, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Fong","sequence":"additional","affiliation":[{"name":"Calico Life Sciences LLC, South San Francisco, CA 94080, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenfei","family":"Kang","sequence":"additional","affiliation":[{"name":"Molecular Cytology Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Fan","sequence":"additional","affiliation":[{"name":"Molecular Cytology Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Mazzoni","sequence":"additional","affiliation":[{"name":"Molecular Cytology Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radhika A","family":"Patel","sequence":"additional","affiliation":[{"name":"Division of Human Biology, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jimmy","family":"Zhao","sequence":"additional","affiliation":[{"name":"Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA"},{"name":"Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazifa","family":"Salsabeel","sequence":"additional","affiliation":[{"name":"Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA"},{"name":"Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harmanpreet","family":"Kaur","sequence":"additional","affiliation":[{"name":"Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ninghui","family":"Mao","sequence":"additional","affiliation":[{"name":"Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Chang","sequence":"additional","affiliation":[{"name":"Antitumor Assessment Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Rosiek","sequence":"additional","affiliation":[{"name":"Molecular Cytology Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Chan","sequence":"additional","affiliation":[{"name":"Molecular Cytology Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murray","family":"Tipping","sequence":"additional","affiliation":[{"name":"Molecular Cytology Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaus","family":"Schultz","sequence":"additional","affiliation":[{"name":"Marie-Jos\u00e9e and Henry R. 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Morrissey , H. Long , P. S. Nelson , M. C. Haffner , Patterns of intra- and intertumor phenotypic heterogeneity in lethal prostate cancer. J. Clin. Invest. 135, e186599.","DOI":"10.1172\/JCI186599"},{"key":"2026082511550708000_2025.12.30.697072v2.56","doi-asserted-by":"publisher","DOI":"10.1172\/JCI128212"},{"key":"2026082511550708000_2025.12.30.697072v2.57","doi-asserted-by":"crossref","unstructured":"J. Gao , B. A. Aksoy , U. Dogrusoz , G. Dresdner , B. Gross , S. O. Sumer , Y. Sun , A. Jacobsen , R. Sinha , E. Larsson , E. Cerami , C. Sander , N. Schultz , Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal. Sci. 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