{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T11:49:56Z","timestamp":1767872996430,"version":"3.49.0"},"posted":{"date-parts":[[2026,1,6]]},"group-title":"Hematology","reference-count":34,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T00:00:00Z","timestamp":1767657600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,1,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>\n                    There is no comparison of iron phenotypes and menses, pregnancies, and live births reports of women with\n                    <jats:italic>HFE<\/jats:italic>\n                    -related hemochromatosis (\n                    <jats:italic>HFE<\/jats:italic>\n                    p.C282Y (rs1800562) homozygosity) and\n                    <jats:italic>HFE<\/jats:italic>\n                    wt\/wt (absence of p.C282Y and\n                    <jats:italic>HFE<\/jats:italic>\n                    p.H63D (rs1799945)).\n                  <\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Subjects and Methods<\/jats:title>\n                  <jats:p>We compared phenotypes and reports of non-Hispanic white women women aged \u226525 y in post-population screening evaluations using univariable methods.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>There were 153 p.C282Y\/p.C282Y and 273 wt\/wt. Median ages were 50 y (25, 86) and 55 y (25, 92), respectively (p=0.0019). Median transferrin saturation (TS), median serum ferritin (SF), and provisional iron overload prevalence were higher in p.C282Y\/p.C282Y (p \u22640.0001, each comparison). Prevalences of documented iron overload (3.3% p.C282Y\/p.C282Y vs. 0.7% wt\/wt), iron overload-related disease (2.0% vs. 0.4%, respectively), and iron deficiency (3.9% vs. 2.6%, respectively) were not significantly different. Median ages at menarche (13 y p.C282Y\/p.C282Y vs. 13 y wt\/wt) and menopause (50 y vs. 49 y, respectively) were not significantly different. Reports of \u201cin-between bleeding?\u201d (24.2% p.C282Y\/p.C282Y vs. 25.2% wt\/wt, respectively), \u201cearly stopping of periods?\u201d (11.8% vs. 13.9%, respectively), and \u201chad a hysterectomy?\u201d (30.1% vs. 35.9%, respectively) were not significantly different. Respective percentage pairs of women with p.C282Y\/p.C282Y and wt\/wt who reported 0, 1, 2, 3, or \u22654 pregnancies (or live births) did not differ significantly. Live births\/pregnancies were 287\/363 (79.1%, p.C282Y\/p.C282Y) and 534\/673 (79.3%, wt\/wt) (p=0.7549).<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>\n                    Median TS, median SF, and provisional iron overload prevalence are greater in women with\n                    <jats:italic>HFE<\/jats:italic>\n                    p.C282Y\/p.C282Y than those with wt\/wt, although reports of menses, pregnancies, and live births are similar.\n                  <\/jats:p>\n                <\/jats:sec>","DOI":"10.64898\/2026.01.02.25338237","type":"posted-content","created":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T03:15:13Z","timestamp":1767755713000},"source":"Crossref","is-referenced-by-count":0,"title":["Comparisons of iron phenotypes and reports of menses, pregnancies, and live births in women with\n                  <i>HFE<\/i>\n                  p.C282Y homozygosity and\n                  <i>HFE<\/i>\n                  wt\/wt"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2876-8276","authenticated-orcid":false,"given":"James C.","family":"Barton","sequence":"first","affiliation":[{"name":"Department of Medicine, The University of Alabama at Birmingham, Birmingham, AL USA"},{"name":"Southern Iron Disorders Center, Brookwood Baptist Medical Center, Birmingham, AL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2646-4466","authenticated-orcid":false,"given":"J. 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