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Altered metabolism has been noted in acute EVD but not studied in PES. We identified differential expression of metabolites involved in multiple metabolic pathways in EVD survivors with PES. This included the tricarboxylic acid cycle, amino acid, nucleotide, and short chain fatty acid metabolism. Several of these pathways are associated with immune dysfunction. The identified metabolites have potential use as biomarkers of post-Ebola syndrome.<\/jats:p>","DOI":"10.64898\/2026.01.02.25343095","type":"posted-content","created":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T03:30:11Z","timestamp":1767756611000},"source":"Crossref","is-referenced-by-count":0,"title":["Metabolic Basis of Post-Infectious Sequelae After Ebola Virus Disease"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2275-4535","authenticated-orcid":false,"given":"Anna","family":"Sanford","sequence":"first","affiliation":[{"name":"Tulane University, New Orleans, LA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4996-4025","authenticated-orcid":false,"given":"Nell","family":"Bond","sequence":"additional","affiliation":[{"name":"Tulane University, New Orleans, LA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4570-201X","authenticated-orcid":false,"given":"Samuel","family":"Ficenec","sequence":"additional","affiliation":[{"name":"Tulane University, New Orleans, LA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte","family":"Osterman","sequence":"additional","affiliation":[{"name":"Tulane University, New Orleans, LA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Payton","family":"Farkas","sequence":"additional","affiliation":[{"name":"Tulane University, New Orleans, LA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9979-4522","authenticated-orcid":false,"given":"Emily","family":"Engel","sequence":"additional","affiliation":[{"name":"Tulane University, New Orleans, LA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8904-9334","authenticated-orcid":false,"given":"Bronwyn","family":"Gunn","sequence":"additional","affiliation":[{"name":"Washington State University, Pullman, WA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4329-0795","authenticated-orcid":false,"given":"Donald S.","family":"Grant","sequence":"additional","affiliation":[{"name":"Kenema Government Hospital, Kenema, Sierra Leone"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Samuels","sequence":"additional","affiliation":[{"name":"Tulane University, New Orleans, LA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8915-0715","authenticated-orcid":false,"given":"Kevin","family":"Zwezdaryk","sequence":"additional","affiliation":[{"name":"Tulane University, New Orleans, LA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6642-5739","authenticated-orcid":false,"given":"John","family":"Schieffelin","sequence":"additional","affiliation":[{"name":"Tulane University, New Orleans, LA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"54368","reference":[{"key":"2026010800451195000_2026.01.02.25343095v1.1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(16)30516-3"},{"key":"2026010800451195000_2026.01.02.25343095v1.2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1805435"},{"key":"2026010800451195000_2026.01.02.25343095v1.3","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofaf129"},{"key":"2026010800451195000_2026.01.02.25343095v1.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2023.09.013"},{"key":"2026010800451195000_2026.01.02.25343095v1.5","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000000580"},{"key":"2026010800451195000_2026.01.02.25343095v1.6","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-023-02309-4"},{"key":"2026010800451195000_2026.01.02.25343095v1.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2017.10.011"},{"key":"2026010800451195000_2026.01.02.25343095v1.8","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciab267"},{"issue":"1","key":"2026010800451195000_2026.01.02.25343095v1.9","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1186\/s12879-022-07604-y","article-title":"The prevalence of Post-Ebola Syndrome hearing loss","volume":"22","year":"2022","journal-title":"Sierra Leone. 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