{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T09:18:06Z","timestamp":1767691086587,"version":"3.48.0"},"posted":{"date-parts":[[2026,1,3]]},"group-title":"Oncology","reference-count":27,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,1,3]],"date-time":"2026-01-03T00:00:00Z","timestamp":1767398400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,1,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Multiple myeloma (MM) is the second most common hematologic malignancy in the U.S.; however, the etiology is poorly understood. We investigated social determinants of health (SDoH) associated with MM incidence and survival among low-income Black and White participants in the Southern Community Cohort Study (SCCS).<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The SCCS enrolled participants aged 40-79 years from 12 Southeastern states. We examined associations between SDoH (residential racial segregation, neighborhood deprivation, population density, persistent poverty, and rurality) geocoded to zip code, with MM incidence and all-cause mortality using multivariable Cox regression analyses. Additional stratified analyses examined MM incidence by obesity status.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Among 74,294 participants, there were 162 MM cases, 133 self-identified as Black individuals and 29 self-identified as White individuals. Living in the highest vs. lowest deprivation areas was associated with 2-fold increased MM risk (HR:2.24; 95% CI:1.01-4.95). Among MM cases, those living in the least vs. most residentially segregated areas had 2-fold increased mortality (HR:2.21; 95% CI:1.03-4.74). Among participants who were not obese, those who lived in the most densely populated areas had a reduced risk of MM compared to those who lived in the least densely populated areas (HR:0.31; 95% CI: 0.14-0.67); and those who lived in urban vs. rural areas had a reduced risk (HR:0.52; 95% CI: 0.32-0.85).<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Discussion<\/jats:title>\n                  <jats:p>SDoH factors including neighborhood deprivation and residential racial segregation could influence MM risk and survival among low-income populations.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>SDOH factors should be considered when developing strategies to reduce overall MM burden, and disparities among people with lower socioeconomic backgrounds.<\/jats:p>\n                <\/jats:sec>","DOI":"10.64898\/2026.01.02.26343344","type":"posted-content","created":{"date-parts":[[2026,1,4]],"date-time":"2026-01-04T01:45:11Z","timestamp":1767491111000},"source":"Crossref","is-referenced-by-count":0,"title":["Social Determinants of Health Associated with Multiple Myeloma Incidence and Survival among a Low-Income Cohort in the Southeastern U.S"],"prefix":"10.64898","author":[{"given":"Anna","family":"Junkins","sequence":"first","affiliation":[{"name":"Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanqing","family":"Wen","sequence":"additional","affiliation":[{"name":"Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Loren","family":"Lipworth","sequence":"additional","affiliation":[{"name":"Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA"},{"name":"Vanderbilt-Ingram Cancer Center, Nashville, TN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xijing","family":"Han","sequence":"additional","affiliation":[{"name":"Vanderbilt-Ingram Cancer Center, Nashville, TN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heather","family":"Munro","sequence":"additional","affiliation":[{"name":"Vanderbilt-Ingram Cancer Center, Nashville, TN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael T.","family":"Mumma","sequence":"additional","affiliation":[{"name":"Vanderbilt-Ingram Cancer Center, Nashville, TN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martha J.","family":"Shrubsole","sequence":"additional","affiliation":[{"name":"Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA"},{"name":"Vanderbilt-Ingram Cancer Center, Nashville, TN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Zheng","sequence":"additional","affiliation":[{"name":"Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA"},{"name":"Vanderbilt-Ingram Cancer Center, Nashville, TN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eden","family":"Biltibo","sequence":"additional","affiliation":[{"name":"Vanderbilt-Ingram Cancer Center, Nashville, TN, USA"},{"name":"Division of Hematology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Staci","family":"Sudenga","sequence":"additional","affiliation":[{"name":"Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA"},{"name":"Vanderbilt-Ingram Cancer Center, Nashville, TN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"54368","reference":[{"key":"2026010601150896000_2026.01.02.26343344v1.1","unstructured":"SEER. 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