{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T22:32:22Z","timestamp":1768343542947,"version":"3.49.0"},"posted":{"date-parts":[[2026,1,11]]},"group-title":"Psychiatry and Clinical Psychology","reference-count":76,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,1,11]],"date-time":"2026-01-11T00:00:00Z","timestamp":1768089600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.medrxiv.org\/about\/FAQ#license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,1,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>Aging is the strongest known risk factor for Alzheimer\u2019s disease (AD), and elevated plasma amyloid-\u03b2 (A\u03b2) levels in healthy adults are associated with increased AD risk. Aging is also associated with autonomic imbalance, characterized by increased sympathetic and decreased parasympathetic activity. In our previous randomized clinical trial, we found that four weeks of daily slow-paced breathing designed to enhance parasympathetic activity reduced plasma A\u03b242 and A\u03b240 levels in younger and older adults and showed a trend toward increasing A\u03b242\/A\u03b240 ratio only in older adults. The primary goal of the current study was to extend these findings in 62 adults aged 50 to 70 years using randomized assignment to 10 weeks of slow-paced breathing or a random-paced breathing control with three assessment time points. Secondary objectives included examining the effects of slow-paced breathing on brain structure (i.e., perivascular space and hippocampal volumes) and cognitive performance. Consistent with prior findings, the slow-paced breathing group showed greater decreases in plasma A\u03b242 than the control group.<\/jats:p>\n                <jats:p>However, group differences were not significant for A\u03b240 or A\u03b242\/A\u03b240 ratios, and no significant effects were observed for the secondary outcomes. The non-significant findings may be due to changes we made to both intervention and control condition methods relative to our previous trial. Further research is needed to explore the underlying mechanisms and potential effects of slow-paced breathing on A\u03b2 accumulation in the brain.<\/jats:p>\n                <jats:sec>\n                  <jats:title>Highlights<\/jats:title>\n                  <jats:list list-type=\"bullet\">\n                    <jats:list-item>\n                      <jats:p>Participants were randomly assigned to slow-placed breathing or a breathing control<\/jats:p>\n                    <\/jats:list-item>\n                    <jats:list-item>\n                      <jats:p>Individualized protocols determined breathing paces<\/jats:p>\n                    <\/jats:list-item>\n                    <jats:list-item>\n                      <jats:p>Ten weeks of daily slow-paced breathing practice reduced plasma A\u03b242 levels<\/jats:p>\n                    <\/jats:list-item>\n                  <\/jats:list>\n                <\/jats:sec>","DOI":"10.64898\/2026.01.08.26343624","type":"posted-content","created":{"date-parts":[[2026,1,11]],"date-time":"2026-01-11T11:55:12Z","timestamp":1768132512000},"source":"Crossref","is-referenced-by-count":0,"title":["Testing effects of paced breathing on plasma A\u03b2 and brain perivascular spaces"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8227-4712","authenticated-orcid":false,"given":"Kaoru","family":"Nashiro","sequence":"first","affiliation":[{"name":"Leonard Davis School of Gerontology, University of Southern California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jungwon","family":"Min","sequence":"additional","affiliation":[{"name":"Leonard Davis School of Gerontology, University of Southern California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5468-8168","authenticated-orcid":false,"given":"Hyun Joo","family":"Yoo","sequence":"additional","affiliation":[{"name":"Leonard Davis School of Gerontology, University of Southern California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Cho","sequence":"additional","affiliation":[{"name":"Leonard Davis School of Gerontology, University of Southern California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3525-0539","authenticated-orcid":false,"given":"Martin J.","family":"Dahl","sequence":"additional","affiliation":[{"name":"Leonard Davis School of Gerontology, University of Southern California"},{"name":"Center for Lifespan Psychology, Max Planck Institute for Human Development"},{"name":"Max Planck UCL Centre for Computational Psychiatry and Ageing Research"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Choi","sequence":"additional","affiliation":[{"name":"Leonard Davis School of Gerontology, University of Southern California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hye Rynn","family":"J. 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