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That said, the majority of studies suffer from a significant limitation\u2014they only focus on a single segment of the eye. This represents a limitation because age-related increases in neuroinflammatory markers are not necessarily uniform within an organ, and other age-related changes in the eye are known to occur in a segment-specific manner. The present study aims to address this gap by comparting\/contrasting age-related changes in the proinflammatory cytokines IL-6 and IL-1\u03b2 across multiple mouse ocular segments: the (i) anterior segment (i.e., cornea, ciliary body and muscle, and zonules), (ii) retina, and (iii) posterior segment (i.e., sclera, choroid, Bruch\u2019s membrane, retinal pigmented epithelium, and parts of the optic nerve). IL-6 and IL-1\u03b2 were selected as targets since they exhibit differential regional patterns of age-related increases within the brain. Eyes were collected on postnatal days (P) P28, P56, P98, P200 and P500 and processed by Western blot. Both IL-6 and IL-1\u03b2 protein levels increased across the lifespan in all three eye segments. Interestingly, correlational analyses revealed that IL-1\u03b2 and IL-6 expression correlated with each other not only within individual eye segments, but also across segments. In old mice, IL-1\u03b2 and IL-6 levels also correlated with expression of phosphodiesterase 11A (PDE11A), an enzyme known to regulate neuroinflammation. Together, these findings suggest that inflammaging in the eye is broadly controlled by a systemic governor, unlike the brain that shows region-specific changes in cytokines with age.<\/jats:p>","DOI":"10.64898\/2026.01.09.698735","type":"posted-content","created":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T14:40:11Z","timestamp":1768228811000},"source":"Crossref","is-referenced-by-count":0,"title":["Age-Related Upregulation and Strong Expression Correlation of the Proinflammatory Cytokines IL-1\u03b2 and IL-6 Across Multiple Segments of the Mouse Eye"],"prefix":"10.64898","author":[{"given":"Haley","family":"Greene","sequence":"first","affiliation":[{"name":"Department of Neurobiology, University of Maryland School of Medicine, Baltimore, MD 21201"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"Sbornova","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, University of Maryland School of Medicine, Baltimore, MD 21201"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michy P.","family":"Kelly","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, University of Maryland School of Medicine, Baltimore, MD 21201"},{"name":"Center for Research on Aging, University of Maryland School of Medicine, Baltimore, MD 21201"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2026020510475917000_2026.01.09.698735v1.1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2000.tb06651.x"},{"key":"2026020510475917000_2026.01.09.698735v1.2","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-018-0059-4"},{"key":"2026020510475917000_2026.01.09.698735v1.3","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glu057"},{"key":"2026020510475917000_2026.01.09.698735v1.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2006.11.016"},{"key":"2026020510475917000_2026.01.09.698735v1.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2008.07.002"},{"key":"2026020510475917000_2026.01.09.698735v1.6","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00586"},{"key":"2026020510475917000_2026.01.09.698735v1.7","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M412170200"},{"key":"2026020510475917000_2026.01.09.698735v1.8","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2004.07.002"},{"key":"2026020510475917000_2026.01.09.698735v1.9","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2003.08.007"},{"key":"2026020510475917000_2026.01.09.698735v1.10","doi-asserted-by":"publisher","DOI":"10.1159\/000049025"},{"key":"2026020510475917000_2026.01.09.698735v1.11","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2015.08.001"},{"key":"2026020510475917000_2026.01.09.698735v1.12","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2024.112433"},{"issue":"10","key":"2026020510475917000_2026.01.09.698735v1.13","doi-asserted-by":"crossref","first-page":"e0293027","DOI":"10.1371\/journal.pone.0293027","article-title":"Blood inflammatory markers and mortality in the US population: A Health and Retirement Survey (HRS) analysis","volume":"18","year":"2023","journal-title":"PLoS One"},{"key":"2026020510475917000_2026.01.09.698735v1.14","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1531903100"},{"issue":"11","key":"2026020510475917000_2026.01.09.698735v1.15","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1093\/gerona\/glz130","article-title":"Inflammaging: Age and Systemic, Cellular, and Nuclear Inflammatory Biology in Older Adults","volume":"74","year":"2019","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"2026020510475917000_2026.01.09.698735v1.16","doi-asserted-by":"crossref","unstructured":"Pinti, M. , et al., A Comprehensive Analysis of Cytokine Network in Centenarians. 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