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With improved acetyl-lysine enrichment technologies and advances in mass spectrometer speed and sensitivity, we present a comprehensive atlas of the mouse acetylome comprising 17,952 unique lysine acetylation sites across 4,340 proteins and 15 tissues. This resource, which nearly doubles the known mouse acetyl-lysine catalog, shows at least 14% of the acetylome is shared across tissues. We focus our investigation on several acetylated proteins, including ribosomal acetylation and its potential to extend ribosomal half-life in the liver and pancreas. Additionally, we identify a novel acetylation event in the active site of carnitine O-acetyltransferase (Crat) that also mirrors tissue-specific Crat activity. By integrating these data with human pathogenic variants, we identify acetyl-lysine residues on cardiac troponin and homogentisate dioxygenase that likely mimic disease-causing mutations. This resource provides a foundational framework for investigating protein acetylation in metabolic health and disease.<\/jats:p>","DOI":"10.64898\/2026.01.09.698739","type":"posted-content","created":{"date-parts":[[2026,1,11]],"date-time":"2026-01-11T02:40:12Z","timestamp":1768099212000},"source":"Crossref","is-referenced-by-count":0,"title":["Atlas of lysine acetylation in the mouse"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2100-5786","authenticated-orcid":false,"given":"Ross W.","family":"Soens","sequence":"first","affiliation":[{"name":"University of Wisconsin-Madison, Department of Biomolecular Chemistry, Madison, WI, USA"},{"name":"Morgridge Institute for Research, Madison, WI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6156-342X","authenticated-orcid":false,"given":"Benton J.","family":"Anderson","sequence":"additional","affiliation":[{"name":"University of Wisconsin-Madison, Department of Biomolecular Chemistry, Madison, WI, USA"},{"name":"Morgridge Institute for Research, Madison, WI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3609-7951","authenticated-orcid":false,"given":"Noah M.","family":"Lancaster","sequence":"additional","affiliation":[{"name":"Morgridge Institute for Research, Madison, WI, USA"},{"name":"University of Wisconsin-Madison Department of Chemistry, Madison, WI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mukesh","family":"Kumar","sequence":"additional","affiliation":[{"name":"Cell Signaling Technology Inc, Danvers, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia K.","family":"Hanssen","sequence":"additional","affiliation":[{"name":"University of Wisconsin-Madison School of Medicine and Public Health, Department of Medicine, Madison, WI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9411-7327","authenticated-orcid":false,"given":"Andrea","family":"Galmozzi","sequence":"additional","affiliation":[{"name":"University of Wisconsin-Madison, Department of Biomolecular Chemistry, Madison, WI, USA"},{"name":"University of Wisconsin-Madison School of Medicine and Public Health, Department of Medicine, Madison, WI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4855-8703","authenticated-orcid":false,"given":"Timothy","family":"Grant","sequence":"additional","affiliation":[{"name":"Morgridge Institute for Research, Madison, WI, USA"},{"name":"University of Wisconsin-Madison, Department of Biochemistry, Madison, WI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1929-1229","authenticated-orcid":false,"given":"Katherine A.","family":"Overmyer","sequence":"additional","affiliation":[{"name":"University of Wisconsin-Madison, Department of Biomolecular Chemistry, Madison, WI, USA"},{"name":"Morgridge Institute for Research, Madison, WI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0004-8253","authenticated-orcid":false,"given":"Joshua J.","family":"Coon","sequence":"additional","affiliation":[{"name":"University of Wisconsin-Madison, Department of Biomolecular Chemistry, Madison, WI, USA"},{"name":"Morgridge Institute for Research, Madison, WI, USA"},{"name":"University of Wisconsin-Madison Department of Chemistry, Madison, WI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2026020421100997000_2026.01.09.698739v1.1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.7b00181"},{"key":"2026020421100997000_2026.01.09.698739v1.2","doi-asserted-by":"publisher","DOI":"10.1038\/47412"},{"key":"2026020421100997000_2026.01.09.698739v1.3","doi-asserted-by":"publisher","DOI":"10.1002\/1521-1878(200009)22:9<836::AID-BIES9>3.0.CO;2-X"},{"key":"2026020421100997000_2026.01.09.698739v1.4","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3841"},{"key":"2026020421100997000_2026.01.09.698739v1.5","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M110.001594"},{"key":"2026020421100997000_2026.01.09.698739v1.6","doi-asserted-by":"publisher","DOI":"10.1042\/bse0520023"},{"key":"2026020421100997000_2026.01.09.698739v1.7","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1302961110"},{"key":"2026020421100997000_2026.01.09.698739v1.8","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2012.07.006"},{"key":"2026020421100997000_2026.01.09.698739v1.9","doi-asserted-by":"publisher","DOI":"10.1126\/science.1175371"},{"key":"2026020421100997000_2026.01.09.698739v1.10","doi-asserted-by":"crossref","unstructured":"Tracy, T. 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