{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T18:51:12Z","timestamp":1784400672056,"version":"3.55.0"},"posted":{"date-parts":[[2026,1,13]]},"group-title":"Epidemiology","reference-count":49,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T00:00:00Z","timestamp":1768262400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,1,13]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                <jats:sec>\n                  <jats:title>INTRODUCTION:<\/jats:title>\n                  <jats:p>Dementia clinical risk scores (CRS) provide accessible tools for identifying individuals at risk for Alzheimer\u2019s disease (AD), yet their performance across diverse populations and relationships to AD endophenotypes remains unclear.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>METHODS:<\/jats:title>\n                  <jats:p>We evaluated four CRS, mCAIDE, WHICAP, LIBRA, and CogDRisk, in relation to cognitive impairment diagnoses and endophenotypes for AD, including plasma biomarkers, neuroimaging measures, and cognitive composite scores. Logistic and linear regression models stratified by self-reported race\/ethnicity were used to assess the associations of CRS with diagnosis and their predictive performance, and associations with endophenotypes.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>RESULTS:<\/jats:title>\n                  <jats:p>Higher CRS were consistently associated with increased odds of dementia across all races\/ethnicities. CogDRisk showed the strongest and most consistent performance across diagnostic and endophenotypic outcomes. The other three CRS performed similarly, with mCAIDE performing the worst and lacking associations with plasma biomarkers.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>CONCLUSIONS:<\/jats:title>\n                  <jats:p>CRS capture AD-related risk across diverse populations and modestly reflect underlying biological endophenotypes, supporting their utility in community-based risk assessment.<\/jats:p>\n                <\/jats:sec>","DOI":"10.64898\/2026.01.10.26343864","type":"posted-content","created":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T16:50:13Z","timestamp":1768323013000},"source":"Crossref","is-referenced-by-count":1,"title":["Associations of dementia polyexposure scores to Alzheimer\u2019s disease endophenotypes in diverse populations"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0487-3031","authenticated-orcid":false,"given":"Meri","family":"Okorie","sequence":"first","affiliation":[{"name":"Edward and Pearl Fein Memory and Aging Center, University of California, San Francisco, San Francisco, CA, USA"},{"name":"Department of Psychiatry and Behavioural Sciences, University of California, San Francisco, San Francisco, USA"},{"name":"The Center for Population Brain Health, University of California, San Francisco, San Francisco, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3633-0688","authenticated-orcid":false,"given":"Xiaqing","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioural Sciences, University of California, San Francisco, San Francisco, USA"},{"name":"The Center for Population Brain Health, University of California, San Francisco, San Francisco, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristine","family":"Yaffe","sequence":"additional","affiliation":[{"name":"Department of Neurology and Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, USA"},{"name":"Edward and Pearl Fein Memory and Aging Center, University of California, San Francisco, San Francisco, CA, USA"},{"name":"Department of Psychiatry and Behavioural Sciences, University of California, San Francisco, San Francisco, USA"},{"name":"Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA"},{"name":"The Center for Population Brain Health, University of California, San Francisco, San Francisco, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7274-2634","authenticated-orcid":false,"given":"Jennifer S.","family":"Yokoyama","sequence":"additional","affiliation":[{"name":"Department of Neurology and Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, USA"},{"name":"Edward and Pearl Fein Memory and Aging Center, University of California, San Francisco, San Francisco, CA, USA"},{"name":"Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1921-9470","authenticated-orcid":false,"given":"Shea J.","family":"Andrews","sequence":"additional","affiliation":[{"name":"Edward and Pearl Fein Memory and Aging Center, University of California, San Francisco, San Francisco, CA, USA"},{"name":"Department of Psychiatry and Behavioural Sciences, University of California, San Francisco, San Francisco, USA"},{"name":"The Center for Population Brain Health, University of California, San Francisco, San Francisco, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the Health and Aging Brain Study \u2013 Health Disparities","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2026011602100514000_2026.01.10.26343864v1.1","first-page":"e12334","article-title":"Alzheimer\u2019s disease diagnosis and management: Perspectives from around the world","volume":"14","year":"2022","journal-title":"Alzheimers Dement. 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