{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T03:58:57Z","timestamp":1793419137844,"version":"4.5.0"},"posted":{"date-parts":[[2026,1,12]]},"group-title":"Neuroscience","reference-count":32,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T00:00:00Z","timestamp":1768176000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.biorxiv.org\/about\/FAQ#license"}],"funder":[{"name":"NIH","award":["DC004260"],"award-info":[{"award-number":["DC004260"]}]},{"name":"Simons Collaboration for the Global Brain","award":["SFI-AN-NC-GB-Culmination-00002796"],"award-info":[{"award-number":["SFI-AN-NC-GB-Culmination-00002796"]}]},{"name":"Nazarbayev University under Faculty-development competitive research grants program","award":["040225FD4718"],"award-info":[{"award-number":["040225FD4718"]}]},{"name":"NIH NINDS","award":["R00NS128075"],"award-info":[{"award-number":["R00NS128075"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,1,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>Head direction (HD) cells in the anterodorsal thalamic nuclei form the brain\u2019s internal compass, and are often modeled as a ring attractor maintaining azimuth coding by leveraging continuous visual and inertial sensory input. Here, we test how the common experimental preparation of head-fixed animals alters this code. Complete head-fixation that creates vestibular conflict disrupts both unit and population encoding of head direction, while selectively constraining head-on-body movements either in real or virtual reality uniquely impairs HD population activity. More specifically, attractor dynamics is altered in head-restrained mice during periods of immobility, but remarkably recover several hundred milliseconds prior to locomotion onset. The rescue preceding movement onset suggests that an efference copy or prediction of a re-afferent signal is necessary to maintain HD network activity during head restraint. A computational model recapitulates these effects by perturbing lateral connectivity among HD neurons. More generally, the results indicate that the HD network is a context- and state-dependent predictive estimator, stabilized by forthcoming self-motion signals. The classic ring-attractor models should be revised to integrate context-dependent dynamics with prospective motor signals, offering a more complete account of how the brain\u2019s compass remains stable across both naturalistic and constrained conditions.<\/jats:p>","DOI":"10.64898\/2026.01.12.698940","type":"posted-content","created":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T06:15:23Z","timestamp":1768284923000},"source":"Crossref","is-referenced-by-count":2,"title":["Active locomotion predictively rescues head direction attractor dynamics in head-fixed mice"],"prefix":"10.64898","author":[{"given":"Alexandr","family":"Pak","sequence":"first","affiliation":[{"name":"Department of Biology, School of Sciences and Humanities, Nazarbayev University, Kabanbay batyr 53, Astana 010000, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janna","family":"Aarse","sequence":"additional","affiliation":[{"name":"Department of Neurophysiology, Ruhr University Bochum, Bochum, Germany"},{"name":"Center for Neural Science, New York University, New York, NY 10003, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heng Wei","family":"Zhu","sequence":"additional","affiliation":[{"name":"Center for Neural Science, New York University, New York, NY 10003, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Paul","family":"Noel","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sim\u00f3n Carrillo","family":"Segura","sequence":"additional","affiliation":[{"name":"Center for Neural Science, New York University, New York, NY 10003, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9 A.","family":"Fenton","sequence":"additional","affiliation":[{"name":"Center for Neural Science, New York University, New York, NY 10003, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dora","family":"Angelaki","sequence":"additional","affiliation":[{"name":"Center for Neural Science, New York University, New York, NY 10003, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2026020421040669000_2026.01.12.698940v1.1","doi-asserted-by":"publisher","DOI":"10.1038\/nature03721"},{"key":"2026020421040669000_2026.01.12.698940v1.2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(71)90358-1"},{"key":"2026020421040669000_2026.01.12.698940v1.3","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.10-02-00420.1990"},{"key":"2026020421040669000_2026.01.12.698940v1.4","doi-asserted-by":"publisher","DOI":"10.1126\/science.1259591"},{"key":"2026020421040669000_2026.01.12.698940v1.5","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.22194"},{"key":"2026020421040669000_2026.01.12.698940v1.6","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.16-06-02112.1996"},{"key":"2026020421040669000_2026.01.12.698940v1.7","doi-asserted-by":"publisher","DOI":"10.1088\/0954-898X_7_4_004"},{"key":"2026020421040669000_2026.01.12.698940v1.8","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1038\/s41467-020-15566-5","article-title":"A gravity-based three-dimensional compass in the mouse brain","volume":"11","year":"2020","journal-title":"Nat Commun"},{"key":"2026020421040669000_2026.01.12.698940v1.9","doi-asserted-by":"publisher","DOI":"10.1038\/nature14031"},{"key":"2026020421040669000_2026.01.12.698940v1.10","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-05813-2"},{"key":"2026020421040669000_2026.01.12.698940v1.11","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3968"},{"key":"2026020421040669000_2026.01.12.698940v1.12","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.neuron.2018.11.019","article-title":"How the Internally Organized Direction Sense Is Used to Navigate","volume":"101","year":"2019","journal-title":"Neuron"},{"key":"2026020421040669000_2026.01.12.698940v1.13","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3884"},{"key":"2026020421040669000_2026.01.12.698940v1.14","doi-asserted-by":"publisher","DOI":"10.7554\/elife.34789"},{"key":"2026020421040669000_2026.01.12.698940v1.15","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.01.050"},{"key":"2026020421040669000_2026.01.12.698940v1.16","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2015.09.012"},{"key":"2026020421040669000_2026.01.12.698940v1.17","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2010.01.033"},{"key":"2026020421040669000_2026.01.12.698940v1.18","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00512.2013"},{"key":"2026020421040669000_2026.01.12.698940v1.19","doi-asserted-by":"crossref","unstructured":"Chen, G. , Lu, Y. , King, J. A. , Cacucci, F. & Burgess, N . Differential influences of environment and self-motion on place and grid cell firing. Nat Commun 10, 630 (2019).","DOI":"10.1038\/s41467-019-08550-1"},{"key":"2026020421040669000_2026.01.12.698940v1.20","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2014.08.042"},{"key":"2026020421040669000_2026.01.12.698940v1.21","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-019-0460-x"},{"key":"2026020421040669000_2026.01.12.698940v1.22","doi-asserted-by":"publisher","DOI":"10.1126\/science.295.5552.7a"},{"key":"2026020421040669000_2026.01.12.698940v1.23","first-page":"61","article-title":"Barcodes: The persistent topology of data","volume":"45","year":"2008","journal-title":"Bull. Amer. Math. Soc"},{"key":"2026020421040669000_2026.01.12.698940v1.24","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.neuron.2017.12.020","article-title":"The brain compass: a perspective on how self-motion updates the head direction cell attractor","volume":"97","year":"2018","journal-title":"Neuron"},{"key":"2026020421040669000_2026.01.12.698940v1.25","doi-asserted-by":"publisher","DOI":"10.1080\/net.13.2.217.242"},{"key":"2026020421040669000_2026.01.12.698940v1.26","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00501.2017"},{"key":"2026020421040669000_2026.01.12.698940v1.27","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1679-08.2009"},{"key":"2026020421040669000_2026.01.12.698940v1.28","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-024-02232-7"},{"key":"2026020421040669000_2026.01.12.698940v1.29","doi-asserted-by":"publisher","DOI":"10.1101\/447995"},{"key":"2026020421040669000_2026.01.12.698940v1.30","doi-asserted-by":"crossref","unstructured":"Levy, E. R. J. et al. A manifold neural population code for space in hippocampal coactivity dynamics independent of place fields. Cell Rep 42, 113142 (2023).","DOI":"10.1016\/j.celrep.2023.113142"},{"key":"2026020421040669000_2026.01.12.698940v1.31","first-page":"2825","article-title":"Scikit-learn: Machine Learning in Python","volume":"12","year":"2011","journal-title":"Journal of Machine Learning Research"},{"key":"2026020421040669000_2026.01.12.698940v1.32","doi-asserted-by":"crossref","unstructured":"Tralie, C. , Saul, N. & Bar-On, R . Ripser.py: A Lean Persistent Homology Library for Python. Journal of Open Source Software 3, 925 (2018).","DOI":"10.21105\/joss.00925"}],"container-title":[],"original-title":[],"link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.64898\/2026.01.12.698940","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T05:04:17Z","timestamp":1770267857000},"score":1,"resource":{"primary":{"URL":"http:\/\/biorxiv.org\/lookup\/doi\/10.64898\/2026.01.12.698940"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,12]]},"references-count":32,"URL":"https:\/\/doi.org\/10.64898\/2026.01.12.698940","relation":{},"subject":[],"published":{"date-parts":[[2026,1,12]]},"subtype":"preprint"}}