{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T14:23:03Z","timestamp":1785421383968,"version":"3.56.0"},"posted":{"date-parts":[[2026,1,14]]},"group-title":"Neuroscience","reference-count":77,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:00:00Z","timestamp":1768348800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.biorxiv.org\/about\/FAQ#license"}],"funder":[{"award":["NS087662"],"award-info":[{"award-number":["NS087662"]}],"id":[{"id":"https:\/\/ror.org\/01s5ya894","id-type":"ROR","asserted-by":"publisher"}]},{"award":["NS081986"],"award-info":[{"award-number":["NS081986"]}],"id":[{"id":"https:\/\/ror.org\/01s5ya894","id-type":"ROR","asserted-by":"publisher"}]},{"award":["NS108378"],"award-info":[{"award-number":["NS108378"]}],"id":[{"id":"https:\/\/ror.org\/01s5ya894","id-type":"ROR","asserted-by":"publisher"}]},{"award":["NS101888"],"award-info":[{"award-number":["NS101888"]}],"id":[{"id":"https:\/\/ror.org\/01s5ya894","id-type":"ROR","asserted-by":"publisher"}]},{"award":["R21NS111338"],"award-info":[{"award-number":["R21NS111338"]}],"id":[{"id":"https:\/\/ror.org\/01s5ya894","id-type":"ROR","asserted-by":"publisher"}]},{"award":["R21NS126914"],"award-info":[{"award-number":["R21NS126914"]}],"id":[{"id":"https:\/\/ror.org\/01s5ya894","id-type":"ROR","asserted-by":"publisher"}]},{"award":["MH118263"],"award-info":[{"award-number":["MH118263"]}],"id":[{"id":"https:\/\/ror.org\/04xeg9z08","id-type":"ROR","asserted-by":"publisher"}]},{"award":["MH097446"],"award-info":[{"award-number":["MH097446"]}],"id":[{"id":"https:\/\/ror.org\/04xeg9z08","id-type":"ROR","asserted-by":"publisher"}]},{"id":[{"id":"https:\/\/ror.org\/05wmdnq05","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,1,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>\n                  Rett syndrome is an X-linked neurodevelopmental disorder resulting from mutations in the MeCP2 gene, leading to intellectual disability, impaired motor coordination, decreased sociability, and seizures. Central to the underlying pathophysiology are deficits in synaptic inhibition, which are mediated by hyperpolarizing GABA\n                  <jats:sub>A<\/jats:sub>\n                  R currents. These events develop postnatally and are dependent upon increased neuronal Cl\n                  <jats:sup>-<\/jats:sup>\n                  extrusion mediated by SLC12A5 (KCC2). Therefore, we tested whether its activation modifies the disease phenotypes evident in female MeCP2\n                  <jats:sup>+\/-<\/jats:sup>\n                  mice, using OV350, a direct activator of KCC2. OV350 rapidly induced a sustained reduction in EEG power, accompanied by a decrease in the severity of epileptic discharges. Increased motor coordination, sociability, and spatial memory were also observed. Deficits in KCC2 phosphorylation were also seen in MeCP2\n                  <jats:sup>+\/-<\/jats:sup>\n                  mice, consistent with reductions in its activity that were also ameliorated by OV350. Thus, KCC2 activation may be efficacious in limiting the impact of Rett syndrome and other neurodevelopmental disorders.\n                <\/jats:p>","DOI":"10.64898\/2026.01.13.699303","type":"posted-content","created":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T11:50:13Z","timestamp":1768391413000},"source":"Crossref","is-referenced-by-count":0,"title":["KCC2 Activation Reverses Neurophysiological and Behavioral Deficits in Female Rett Mice"],"prefix":"10.64898","author":[{"given":"Muhammad Nauman","family":"Arshad","sequence":"first","affiliation":[{"name":"Department of Neuroscience, Tufts University School of Medicine, 136 Harrison Ave, Boston, MA 02111, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu Fun Josephine","family":"Ng","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Tufts University School of Medicine, 136 Harrison Ave, Boston, MA 02111, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seda","family":"Salar","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Tufts University School of Medicine, 136 Harrison Ave, Boston, MA 02111, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krithika","family":"Abiraman","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Tufts University School of Medicine, 136 Harrison Ave, Boston, MA 02111, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiya","family":"Nishi","sequence":"additional","affiliation":[{"name":"Ovid Therapeutics, 1460 Broadway, Fl 4, New York, NY 10036,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong","family":"Zhong","sequence":"additional","affiliation":[{"name":"Ovid Therapeutics, 1460 Broadway, Fl 4, New York, NY 10036,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua L","family":"Smalley","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Tufts University School of Medicine, 136 Harrison Ave, Boston, MA 02111, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul A","family":"Davies","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Tufts University School of Medicine, 136 Harrison Ave, Boston, MA 02111, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen J.","family":"Moss","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Tufts University School of Medicine, 136 Harrison Ave, Boston, MA 02111, United States"},{"name":"Department of Neuroscience, Physiology and Pharmacology, University College London, WC1 6BT, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2026020605383018000_2026.01.13.699303v1.1","doi-asserted-by":"publisher","DOI":"10.1002\/mrdd.10027"},{"key":"2026020605383018000_2026.01.13.699303v1.2","doi-asserted-by":"publisher","DOI":"10.1177\/08830738050200082401"},{"key":"2026020605383018000_2026.01.13.699303v1.3","doi-asserted-by":"publisher","DOI":"10.1038\/s41583-018-0006-3"},{"key":"2026020605383018000_2026.01.13.699303v1.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2007.04.005"},{"key":"2026020605383018000_2026.01.13.699303v1.5","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1524013113"},{"key":"2026020605383018000_2026.01.13.699303v1.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2017.06.008"},{"key":"2026020605383018000_2026.01.13.699303v1.7","doi-asserted-by":"crossref","unstructured":"Moore YE , Conway LC , Wobst HJ , Brandon NJ , Deeb TZ , Moss SJ . Developmental Regulation of KCC2 Phosphorylation Has Long-Term Impacts on Cognitive Function. Frontiers in Molecular Neuroscience 2019; 12.","DOI":"10.3389\/fnmol.2019.00173"},{"key":"2026020605383018000_2026.01.13.699303v1.8","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M705053200"},{"key":"2026020605383018000_2026.01.13.699303v1.9","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181d6b852"},{"key":"2026020605383018000_2026.01.13.699303v1.10","doi-asserted-by":"publisher","DOI":"10.5698\/1535-7511-12.5.184"},{"key":"2026020605383018000_2026.01.13.699303v1.11","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3155"},{"key":"2026020605383018000_2026.01.13.699303v1.12","doi-asserted-by":"publisher","DOI":"10.1038\/nature10360"},{"key":"2026020605383018000_2026.01.13.699303v1.13","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2015.11.019"},{"key":"2026020605383018000_2026.01.13.699303v1.14","doi-asserted-by":"crossref","unstructured":"Zikopoulos B , Barbas H . Altered neural connectivity in excitatory and inhibitory cortical circuits in autism. Front Hum Neurosci 2013; 7: 609.","DOI":"10.3389\/fnhum.2013.00609"},{"key":"2026020605383018000_2026.01.13.699303v1.15","doi-asserted-by":"crossref","unstructured":"Arshad MN , Bope C , Dengler JS , Ng SFJ , Smalley J , Nishi T et al. Activation of KCC2 during development alleviates cognitive, behavioral, and neural excitability in adult CDKL5-deficient mice. bioRxiv 2025.","DOI":"10.1101\/2025.02.26.640365"},{"issue":"23","key":"2026020605383018000_2026.01.13.699303v1.16","doi-asserted-by":"crossref","first-page":"3276","DOI":"10.1093\/hmg\/ddad149","article-title":"CDKL5-mediated developmental tuning of neuronal excitability and concomitant regulation of transcriptome","volume":"32","year":"2023","journal-title":"Hum Mol Genet"},{"key":"2026020605383018000_2026.01.13.699303v1.17","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0506071102"},{"key":"2026020605383018000_2026.01.13.699303v1.18","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1615330113"},{"key":"2026020605383018000_2026.01.13.699303v1.19","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(01)00297-5"},{"key":"2026020605383018000_2026.01.13.699303v1.20","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.ebiom.2018.05.029","article-title":"Locally Reducing KCC2 Activity in the Hippocampus is Sufficient to Induce Temporal Lobe Epilepsy","volume":"32","year":"2018","journal-title":"EBioMedicine"},{"key":"2026020605383018000_2026.01.13.699303v1.21","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2010.203703"},{"issue":"4","key":"2026020605383018000_2026.01.13.699303v1.22","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1038\/sj.npp.1301195","article-title":"KCC2-deficient mice show reduced sensitivity to diazepam, but normal alcohol-induced motor impairment, gaboxadol-induced sedation, and neurosteroid-induced hypnosis","volume":"32","year":"2007","journal-title":"Neuropsychopharmacology"},{"key":"2026020605383018000_2026.01.13.699303v1.23","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2005.03959.x"},{"key":"2026020605383018000_2026.01.13.699303v1.24","doi-asserted-by":"crossref","unstructured":"Kreis A , Issa F , Yerna X , Jabbour C , Schakman O , de Clippele M et al. Conditional deletion of KCC2 impairs synaptic plasticity and both spatial and nonspatial memory. Frontiers in Molecular Neuroscience 2023; Volume 16 - 2023.","DOI":"10.3389\/fnmol.2023.1081657"},{"issue":"3","key":"2026020605383018000_2026.01.13.699303v1.25","doi-asserted-by":"crossref","first-page":"100957","DOI":"10.1016\/j.xcrm.2023.100957","article-title":"Direct activation of KCC2 arrests benzodiazepine refractory status epilepticus and limits the subsequent neuronal injury in mice","volume":"4","year":"2023","journal-title":"Cell Rep Med"},{"issue":"1","key":"2026020605383018000_2026.01.13.699303v1.26","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s11689-019-9275-z","article-title":"Electroencephalographic spectral power as a marker of cortical function and disease severity in girls with Rett syndrome","volume":"11","year":"2019","journal-title":"Journal of Neurodevelopmental Disorders"},{"key":"2026020605383018000_2026.01.13.699303v1.27","doi-asserted-by":"publisher","DOI":"10.1177\/08830738050200090801"},{"issue":"null","key":"2026020605383018000_2026.01.13.699303v1.28","first-page":"925","article-title":"Management of epilepsy in patients with Rett syndrome: perspectives and considerations","volume":"11","year":"2015","journal-title":"Therapeutics and Clinical Risk Management"},{"issue":"1","key":"2026020605383018000_2026.01.13.699303v1.29","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.ejpn.2006.09.003","article-title":"Treatment of epilepsy in Rett syndrome","volume":"11","year":"2007","journal-title":"European Journal of Paediatric Neurology"},{"key":"2026020605383018000_2026.01.13.699303v1.30","first-page":"925","article-title":"Management of epilepsy in patients with Rett syndrome: perspectives and considerations","volume":"11","year":"2015","journal-title":"Ther Clin Risk Manag"},{"key":"2026020605383018000_2026.01.13.699303v1.31","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320250522"},{"issue":"1","key":"2026020605383018000_2026.01.13.699303v1.32","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.neucli.2003.08.003","article-title":"Rett syndrome: a case presenting with atypical seizures","volume":"34","year":"2004","journal-title":"Neurophysiological and clinical aspects. Neurophysiologie Clinique\/Clinical Neurophysiology"},{"key":"2026020605383018000_2026.01.13.699303v1.33","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2018.01.015"},{"key":"2026020605383018000_2026.01.13.699303v1.34","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2010.02597.x"},{"key":"2026020605383018000_2026.01.13.699303v1.35","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.yebeh.2016.10.006","article-title":"Effectiveness and tolerability of antiepileptic drugs in 104 girls with Rett syndrome","volume":"66","year":"2017","journal-title":"Epilepsy & Behavior"},{"issue":"3","key":"2026020605383018000_2026.01.13.699303v1.36","doi-asserted-by":"crossref","first-page":"253","DOI":"10.31887\/DCNS.2012.14.3\/jneul","article-title":"The relationship of Rett syndrome and MECP2 disorders to autism","volume":"14","year":"2012","journal-title":"Dialogues Clin Neurosci"},{"key":"2026020605383018000_2026.01.13.699303v1.37","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddi016"},{"key":"2026020605383018000_2026.01.13.699303v1.38","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0908840106"},{"issue":"5","key":"2026020605383018000_2026.01.13.699303v1.39","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1002\/ana.25712","article-title":"Neurophysiological Signatures of Motor Impairment in Patients with Rett Syndrome","volume":"87","year":"2020","journal-title":"Ann Neurol"},{"key":"2026020605383018000_2026.01.13.699303v1.40","doi-asserted-by":"crossref","unstructured":"Guyenet SJ , Furrer SA , Damian VM , Baughan TD , La Spada AR , Garden GA . A simple composite phenotype scoring system for evaluating mouse models of cerebellar ataxia. J Vis Exp 2010; (39).","DOI":"10.3791\/1787-v"},{"key":"2026020605383018000_2026.01.13.699303v1.41","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2020.02.023"},{"key":"2026020605383018000_2026.01.13.699303v1.42","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.03.013"},{"key":"2026020605383018000_2026.01.13.699303v1.43","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.bbi.2016.02.014","article-title":"CX(3)CR1 ablation ameliorates motor and respiratory dysfunctions and improves survival of a Rett syndrome mouse model","volume":"60","year":"2017","journal-title":"Brain Behav Immun"},{"key":"2026020605383018000_2026.01.13.699303v1.44","doi-asserted-by":"publisher","DOI":"10.1007\/BF00656997"},{"key":"2026020605383018000_2026.01.13.699303v1.45","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00673.2011"},{"key":"2026020605383018000_2026.01.13.699303v1.46","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-1096-0_14"},{"key":"2026020605383018000_2026.01.13.699303v1.47","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddr066"},{"key":"2026020605383018000_2026.01.13.699303v1.48","doi-asserted-by":"publisher","DOI":"10.1038\/s41436-018-0348-2"},{"key":"2026020605383018000_2026.01.13.699303v1.49","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2806"},{"key":"2026020605383018000_2026.01.13.699303v1.50","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5889-12.2013"},{"key":"2026020605383018000_2026.01.13.699303v1.51","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0114328"},{"key":"2026020605383018000_2026.01.13.699303v1.52","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1415126112"},{"key":"2026020605383018000_2026.01.13.699303v1.53","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-01749-0"},{"key":"2026020605383018000_2026.01.13.699303v1.54","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1810134115"},{"key":"2026020605383018000_2026.01.13.699303v1.55","doi-asserted-by":"crossref","unstructured":"C\u00f4me E , Heubl M , Schwartz EJ , Poncer JC , L\u00e9vi S . Reciprocal Regulation of KCC2 Trafficking and Synaptic Activity. Front Cell Neurosci 2019; 13: 48.","DOI":"10.3389\/fncel.2019.00048"},{"key":"2026020605383018000_2026.01.13.699303v1.56","doi-asserted-by":"crossref","unstructured":"Bela\u00efdouni Y , Diabira D , Zhang J , Graziano JC , Bader F , Montheil A et al. The Chloride Homeostasis of CA3 Hippocampal Neurons Is Not Altered in Fully Symptomatic Mepc2-null Mice. Front Cell Neurosci 2021; 15: 724976.","DOI":"10.3389\/fncel.2021.724976"},{"key":"2026020605383018000_2026.01.13.699303v1.57","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awab343"},{"issue":"1","key":"2026020605383018000_2026.01.13.699303v1.58","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1186\/s40478-019-0852-x","article-title":"KCC2 expression levels are reduced in post mortem brain tissue of Rett syndrome patients","volume":"7","year":"2019","journal-title":"Acta Neuropathologica Communications"},{"issue":"13","key":"2026020605383018000_2026.01.13.699303v1.59","doi-asserted-by":"crossref","first-page":"2885","DOI":"10.1093\/cercor\/bhab388","article-title":"Region-Specific KCC2 Rescue by rhIGF-1 and Oxytocin in a Mouse Model of Rett Syndrome","volume":"32","year":"2022","journal-title":"Cereb Cortex"},{"key":"2026020605383018000_2026.01.13.699303v1.60","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddq563"},{"issue":"1","key":"2026020605383018000_2026.01.13.699303v1.61","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1038\/s41398-022-02216-1","article-title":"Wide spectrum of neuronal and network phenotypes in human stem cell-derived excitatory neurons with Rett syndrome-associated MECP2 mutations","volume":"12","year":"2022","journal-title":"Translational Psychiatry"},{"key":"2026020605383018000_2026.01.13.699303v1.62","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aww302"},{"key":"2026020605383018000_2026.01.13.699303v1.63","doi-asserted-by":"publisher","DOI":"10.1177\/1362361309338184"},{"key":"2026020605383018000_2026.01.13.699303v1.64","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl022"},{"key":"2026020605383018000_2026.01.13.699303v1.65","doi-asserted-by":"crossref","unstructured":"Tang X , Drotar J , Li K , Clairmont CD , Brumm AS , Sullins AJ et al. Pharmacological enhancement of KCC2 gene expression exerts therapeutic effects on human Rett syndrome neurons and Mecp2 mutant mice. Sci Transl Med 2019; 11(503).","DOI":"10.1126\/scitranslmed.aau0164"},{"key":"2026020605383018000_2026.01.13.699303v1.66","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2015.04.005"},{"key":"2026020605383018000_2026.01.13.699303v1.67","doi-asserted-by":"crossref","unstructured":"Gon\u00e7alez JL , Shen J , Li W . Molecular Mechanisms of Rett Syndrome: Emphasizing the Roles of Monoamine, Immunity, and Mitochondrial Dysfunction. Cells 2024; 13(24).","DOI":"10.3390\/cells13242077"},{"issue":"24","key":"2026020605383018000_2026.01.13.699303v1.68","doi-asserted-by":"crossref","first-page":"9539","DOI":"10.3390\/ijms21249539","article-title":"The Role of Astrocytes in the Modulation ofK+-Cl\u2212-Cotransporter-2 Function","volume":"21","year":"2020","journal-title":"International Journal of Molecular Sciences"},{"issue":"4","key":"2026020605383018000_2026.01.13.699303v1.69","first-page":"366","article-title":"Effects of \u03b17 Nicotinic Acetylcholine Receptor Positive Allosteric Modulator on BDNF, NKCC1 and KCC2 Expression in the Hippocampus following Lipopolysaccharide-Induced Allodynia and Hyperalgesia in a Mouse Model of Inflammatory Pain","volume":"20","year":"2021","journal-title":"CNS & Neurological Disorders - Drug Targets (Formerly Current Drug Targets - CNS & Neurological Disorders)"},{"issue":"1","key":"2026020605383018000_2026.01.13.699303v1.70","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1186\/s12871-024-02587-6","article-title":"Isoflurane-induced neuroinflammation and NKCC1\/KCC2 dysregulation result in long-term cognitive disorder in neonatal mice","volume":"24","year":"2024","journal-title":"BMC Anesthesiology"},{"key":"2026020605383018000_2026.01.13.699303v1.71","doi-asserted-by":"crossref","unstructured":"Colmers PLW , Arshad MN , Mukherjee J , Lin S , Ng SFJ , Sarmiere P et al. Sustained Inhibition of GABA-AT by OV329 Enhances Neuronal Inhibition and Prevents Development of Benzodiazepine Refractory Seizures. eNeuro 2024; 11(7).","DOI":"10.1523\/ENEURO.0137-24.2024"},{"issue":"4","key":"2026020605383018000_2026.01.13.699303v1.72","first-page":"e3533","article-title":"Induction of Temporal Lobe Epilepsy in Mice with Pilocarpine","volume":"10","year":"2020","journal-title":"Bio Protoc"},{"key":"2026020605383018000_2026.01.13.699303v1.73","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddx087"},{"key":"2026020605383018000_2026.01.13.699303v1.74","doi-asserted-by":"crossref","unstructured":"Arshad MN , Pinto A , van Praag H , Naegele JR . Altered connectomes of adult-born granule cells following engraftment of GABAergic progenitors in the mouse hippocampus. Prog Neurobiol 2023; 226: 102450.","DOI":"10.1016\/j.pneurobio.2023.102450"},{"key":"2026020605383018000_2026.01.13.699303v1.75","doi-asserted-by":"crossref","unstructured":"Arshad MN , Oppenheimer S , Jeong J , Buyukdemirtas B , Naegele JR . Hippocampal transplants of fetal GABAergic progenitors regulate adult neurogenesis in mice with temporal lobe epilepsy. Neurobiology of Disease 2022; 174: 105879.","DOI":"10.1016\/j.nbd.2022.105879"},{"key":"2026020605383018000_2026.01.13.699303v1.76","doi-asserted-by":"crossref","unstructured":"Choi C , Smalley JL , Lemons AHS , Ren Q , Bope CE , Dengler JS et al. Analyzing the mechanisms that facilitate the subtype-specific assembly of \u03b3-aminobutyric acid type A receptors. Front Mol Neurosci 2022; 15: 1017404.","DOI":"10.3389\/fnmol.2022.1017404"},{"key":"2026020605383018000_2026.01.13.699303v1.77","doi-asserted-by":"crossref","unstructured":"Smalley JL , Kontou G , Choi C , Ren Q , Albrecht D , Abiraman K et al. Isolation and Characterization of Multi-Protein Complexes Enriched in the K-Cl Co-transporter 2 From Brain Plasma Membranes. Front Mol Neurosci 2020; 13: 563091.","DOI":"10.3389\/fnmol.2020.563091"}],"container-title":[],"original-title":[],"link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.64898\/2026.01.13.699303","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T13:38:43Z","timestamp":1770385123000},"score":1,"resource":{"primary":{"URL":"http:\/\/biorxiv.org\/lookup\/doi\/10.64898\/2026.01.13.699303"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,14]]},"references-count":77,"URL":"https:\/\/doi.org\/10.64898\/2026.01.13.699303","relation":{},"subject":[],"published":{"date-parts":[[2026,1,14]]},"subtype":"preprint"}}