{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T00:09:08Z","timestamp":1768954148541,"version":"3.49.0"},"posted":{"date-parts":[[2026,1,16]]},"group-title":"Endocrinology (including Diabetes Mellitus and Metabolic Disease)","reference-count":49,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T00:00:00Z","timestamp":1768521600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,1,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Hypertensive disorders of pregnancy (HDP) affect up to 15% of pregnancies and are linked to adverse maternal and fetal outcomes. Primary aldosteronism (PA) affects up to 25% of hypertensive patients. We examined PA prevalence in women with prior HDP and its relationship to hypertension trajectory.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Adults from across the U.S.A. meeting guideline-recommended screening criteria for PA were prospectively tested. Women with a self-reported history of HDP completed a questionnaire examining the relationship between PA and hypertension trajectory.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>\n                    Of 330 hypertensive parous women (62.4 \u00b1 9.8y; 32.1% non-white), 83 (25.2%) reported a history of HDP. Women with HDP were younger at hypertension diagnosis (38.8 vs. 47.9y; p &lt;0.001). The prevalence of a positive PA test was similarly high in those with and without HDP (26.5% vs 32%;\n                    <jats:italic>p = 0.35<\/jats:italic>\n                    ). Among women with HDP, 63 completed the follow-up questionnaire, of whom 15 (23.8%) tested positive for PA. Compared with PA-negative women, those with PA reported a higher proportion of pregnancies complicated by hypertension (76.5% vs. 60.9%, p = 0.11) and fetal complications (55.6% vs. 27.9%, p &lt;0.01). Hypertension trajectories also differed: sustained hypertension, defined as persistently elevated blood pressure beyond the postpartum period, was nearly twice as frequent in women with a positive PA test (66.7 vs. 37.5%; p=0.047).\n                  <\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Over 25% of women with hypertension and a prior pregnancy screened positive for PA, highlighting its high prevalence, irrespective of history of HDP. Women with HDP remain at elevated cardiovascular risk, and PA may represent a targetable contributor.<\/jats:p>\n                <\/jats:sec>","DOI":"10.64898\/2026.01.14.26343954","type":"posted-content","created":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T01:55:19Z","timestamp":1768614919000},"source":"Crossref","is-referenced-by-count":0,"title":["Hypertensive Disorders of Pregnancy and Primary Aldosteronism"],"prefix":"10.64898","author":[{"given":"St\u00e9fanie","family":"Parisien-La Salle","sequence":"first","affiliation":[{"name":"Center for Adrenal Disorders, Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women\u2019s Hospital and Harvard Medical School, Boston, MA"},{"name":"Division of Endocrinology, Department of Medicine, Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, QC, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnaldo","family":"Ferrebus","sequence":"additional","affiliation":[{"name":"Center for Adrenal Disorders, Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women\u2019s Hospital and Harvard Medical School, Boston, MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva E","family":"Abel","sequence":"additional","affiliation":[{"name":"Center for Adrenal Disorders, Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women\u2019s Hospital and Harvard Medical School, Boston, MA"},{"name":"Division of Cardiovascular Medicine, Brigham and Women\u2019s Hospital and Harvard Medical School, Boston, MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura C","family":"Tsai","sequence":"additional","affiliation":[{"name":"Center for Adrenal Disorders, Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women\u2019s Hospital and Harvard Medical School, Boston, MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew J","family":"Newman","sequence":"additional","affiliation":[{"name":"Center for Adrenal Disorders, Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women\u2019s Hospital and Harvard Medical School, Boston, MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng Hsuan","family":"Tsai","sequence":"additional","affiliation":[{"name":"Center for Adrenal Disorders, Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women\u2019s Hospital and Harvard Medical School, Boston, MA"},{"name":"Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan"},{"name":"Primary Aldosteronism Center at National Taiwan University Hospital, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anand","family":"Vaidya","sequence":"additional","affiliation":[{"name":"Center for Adrenal Disorders, Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women\u2019s Hospital and Harvard Medical School, Boston, MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6647-639X","authenticated-orcid":false,"given":"Jenifer M","family":"Brown","sequence":"additional","affiliation":[{"name":"Center for Adrenal Disorders, Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women\u2019s Hospital and Harvard Medical School, Boston, MA"},{"name":"Division of Cardiovascular Medicine, Brigham and Women\u2019s Hospital and Harvard Medical School, Boston, MA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"54368","reference":[{"issue":"3","key":"2026012003250622000_2026.01.14.26343954v1.1","first-page":"100864","article-title":"Hypertensive Disorders of Pregnancy","volume":"3","year":"2024","journal-title":"JACC: Advances"},{"key":"2026012003250622000_2026.01.14.26343954v1.2","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm7117a1"},{"key":"2026012003250622000_2026.01.14.26343954v1.3","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31470-2"},{"key":"2026012003250622000_2026.01.14.26343954v1.4","doi-asserted-by":"publisher","DOI":"10.1161\/HYP.0000000000000208"},{"key":"2026012003250622000_2026.01.14.26343954v1.5","doi-asserted-by":"publisher","DOI":"10.7326\/M20-0065"},{"key":"2026012003250622000_2026.01.14.26343954v1.6","doi-asserted-by":"crossref","unstructured":"Adler GK , Stowasser M , Correa RR , Khan N , Kline G , McGowan MJ , et al. 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