{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T10:14:41Z","timestamp":1785406481249,"version":"3.56.0"},"posted":{"date-parts":[[2026,1,18]]},"group-title":"Developmental Biology","reference-count":80,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T00:00:00Z","timestamp":1768694400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nd\/4.0\/"}],"funder":[{"award":["DE028527"],"award-info":[{"award-number":["DE028527"]}],"id":[{"id":"https:\/\/ror.org\/001d55x84","id-type":"ROR","asserted-by":"publisher"}]},{"award":["DE027569"],"award-info":[{"award-number":["DE027569"]}],"id":[{"id":"https:\/\/ror.org\/001d55x84","id-type":"ROR","asserted-by":"publisher"}]},{"award":["S10OD038119"],"award-info":[{"award-number":["S10OD038119"]}],"id":[{"id":"https:\/\/ror.org\/001d55x84","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,1,18]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                <jats:p>\n                  Ischemic injury and adverse post-infarction myocardial remodeling are major causes of heart failure. We previously reported that microRNA (\n                  <jats:italic>miR)-200c<\/jats:italic>\n                  inhibition in murine embryos increased cardiogenic transcription factors (TFs)\n                  <jats:italic>Tbx5<\/jats:italic>\n                  ,\n                  <jats:italic>Gata4<\/jats:italic>\n                  , and\n                  <jats:italic>Mef2c<\/jats:italic>\n                  to activate an immature cardiomyocyte cell state, suggesting\n                  <jats:italic>miR-200<\/jats:italic>\n                  inhibition as a therapy for cardiac repair. We performed permanent ligation of the left anterior descending artery (a severe myocardial infarct, MI) on\n                  <jats:italic>PMIS-miR-200c<\/jats:italic>\n                  (inhibition of\n                  <jats:italic>miR-200c; PMIS-C<\/jats:italic>\n                  ),\n                  <jats:italic>PMIS-A<\/jats:italic>\n                  (inhibition of\n                  <jats:italic>miR-200a<\/jats:italic>\n                  ) and wildtype adult mice. Echocardiographic left ventricular (LV) ejection fraction (EF) at 3 WPI (weeks post-injury) was 22% \u00b1 4.31% (WT) but increased to 56% \u00b1 4.25% (\n                  <jats:italic>PMIS-C<\/jats:italic>\n                  ) (p \u2264 0.0001). Post-infarction LV chamber dilation was reversed in\n                  <jats:italic>PMIS-C<\/jats:italic>\n                  mice compared to WT, and trichrome staining showed a decrease in fibrosis 3 WPI. By 9 WPI,\n                  <jats:italic>PMIS-C<\/jats:italic>\n                  heart function was like that of WT mice before injury. Tbx5, Gata4, Mef2c, and Isl-1 were increased after MI in\n                  <jats:italic>PMIS-C<\/jats:italic>\n                  hearts.\n                  <jats:italic>PMIS-C<\/jats:italic>\n                  mice recover cardiac function and reverse ischemic pathology of acute cardiac injury in adult mice. Inhibition of\n                  <jats:italic>miR-200c<\/jats:italic>\n                  activates several important pathways in heart development and repair mechanisms after an MI in adult hearts. The\n                  <jats:italic>PMIS-miR-200c<\/jats:italic>\n                  transgenic mice demonstrate an important role for\n                  <jats:italic>miR-200c<\/jats:italic>\n                  in regulating heart repair after ischemic injury.\n                <\/jats:p>\n                <jats:sec>\n                  <jats:title>Novelty and Significance<\/jats:title>\n                  <jats:sec>\n                    <jats:title>What is known?<\/jats:title>\n                    <jats:p>\n                      <jats:bold>*<\/jats:bold>\n                      The\n                      <jats:italic>microRNA-200<\/jats:italic>\n                      (\n                      <jats:italic>miR-200<\/jats:italic>\n                      ) family targets several heart factors\n                      <jats:italic>in vitro<\/jats:italic>\n                      .\n                    <\/jats:p>\n                    <jats:p>\n                      *\n                      <jats:italic>miR-200c<\/jats:italic>\n                      inhibition was shown to protect cardiomyocytes in a myocardial ischemia-reperfusion injury, myocardial cellular model.\n                    <\/jats:p>\n                    <jats:p>\n                      *\n                      <jats:italic>miR-200<\/jats:italic>\n                      may play a role in cardiovascular fibrosis, however there are no\n                      <jats:italic>in vivo<\/jats:italic>\n                      reports of the role\n                      <jats:italic>miR-200<\/jats:italic>\n                      plays in heart repair.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>What New Information Does This Article Contribute?<\/jats:title>\n                    <jats:p>\n                      *\n                      <jats:italic>PMIS-miR-200c<\/jats:italic>\n                      transgenic mice reveal a role for\n                      <jats:italic>miR-200c<\/jats:italic>\n                      inhibition in rapid repair of the heart after a myocardial infarct (MI). After an MI,\n                      <jats:italic>miR-200c<\/jats:italic>\n                      expression increases, to levels observed during early heart development.\n                    <\/jats:p>\n                    <jats:p>\n                      <jats:bold>*<\/jats:bold>\n                      Inhibition of\n                      <jats:italic>miR-200c<\/jats:italic>\n                      allows for expression of Tbx5, Gata4, Pitx2, Mef2c, Yap, Nppa and Sox5 factors to repair the heart after ischemic injury.\n                    <\/jats:p>\n                    <jats:p>\n                      *\n                      <jats:italic>PMIS-miR-200c<\/jats:italic>\n                      mice have increased cardiomyocyte proliferation and reduced cardiac fibroblasts resulting in decreased fibrosis.\n                    <\/jats:p>\n                    <jats:p>\n                      *Heart function in\n                      <jats:italic>PMIS-miR-200c<\/jats:italic>\n                      mice is significantly restored 3-weeks post-MI.\n                    <\/jats:p>\n                    <jats:p>\n                      While microRNAs have been extensively studied in heart development and ischemic injury, little is known about the\n                      <jats:italic>miR-200<\/jats:italic>\n                      family in the cardiovascular system. In other cell types and systems,\n                      <jats:italic>miR-200<\/jats:italic>\n                      is upregulated under oxidative stress and hypoxia.\n                      <jats:italic>miR-200c<\/jats:italic>\n                      targets Zeb1, eNOS, Sirt1 and Fox01 to regulate cell growth and arrest, apoptosis and senescence in other tissues.\n                      <jats:italic>miR-200<\/jats:italic>\n                      members are increased in response to ischemia, but this has not been evaluated in the heart. We show a direct effect of\n                      <jats:italic>miR-200c<\/jats:italic>\n                      inhibition and decreased fibrosis in the MI heart. The\n                      <jats:italic>miR-200<\/jats:italic>\n                      family targets stem cell factors such as Sox2, Klf4, and Bmi1 and our recent sn-RNA multiomics analyses of\n                      <jats:italic>PMIS-miR-200c<\/jats:italic>\n                      mice revealed de-differentiated or immature cardiomyocytes. Thus, inhibition of\n                      <jats:italic>miR-200c<\/jats:italic>\n                      reactivates transcription factors after an MI, important for cardiomyocyte renewal. This research demonstrates how inhibition of\n                      <jats:italic>miR-200<\/jats:italic>\n                      regulates cardiac function after an MI.\n                    <\/jats:p>\n                  <\/jats:sec>\n                <\/jats:sec>","DOI":"10.64898\/2026.01.16.700013","type":"posted-content","created":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T20:15:19Z","timestamp":1768767319000},"source":"Crossref","is-referenced-by-count":0,"title":["Activation of developmental transcription factors using RNA technology promotes heart repair"],"prefix":"10.64898","author":[{"given":"Riley J.","family":"Leonard","sequence":"first","affiliation":[{"name":"Lillehei Heart Institute, The University of Minnesota, Minneapolis, MN, 55455 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mason","family":"Sweat","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Texas Southwestern, Dallas TX 75390 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Eliason","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology, The University of Iowa, Iowa City, IA 52242 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Kutschke","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, The University of Iowa, Iowa City, IA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6524-1006","authenticated-orcid":false,"given":"Brad A.","family":"Amendt","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology, The University of Iowa, Iowa City, IA 52242 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2026020608144422000_2026.01.16.700013v1.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)32203-7"},{"key":"2026020608144422000_2026.01.16.700013v1.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2010.03.032"},{"key":"2026020608144422000_2026.01.16.700013v1.3","doi-asserted-by":"publisher","DOI":"10.1186\/s13619-021-00077-5"},{"key":"2026020608144422000_2026.01.16.700013v1.4","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2020.637538"},{"key":"2026020608144422000_2026.01.16.700013v1.5","doi-asserted-by":"publisher","DOI":"10.1126\/science.1077857"},{"key":"2026020608144422000_2026.01.16.700013v1.6","doi-asserted-by":"publisher","DOI":"10.1126\/science.1200708"},{"key":"2026020608144422000_2026.01.16.700013v1.7","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abd6892"},{"key":"2026020608144422000_2026.01.16.700013v1.8","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.118.314223"},{"key":"2026020608144422000_2026.01.16.700013v1.9","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.02.014"},{"key":"2026020608144422000_2026.01.16.700013v1.10","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2014.10.003"},{"key":"2026020608144422000_2026.01.16.700013v1.11","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0251054"},{"key":"2026020608144422000_2026.01.16.700013v1.12","doi-asserted-by":"publisher","DOI":"10.1038\/s41536-023-00280-9"},{"key":"2026020608144422000_2026.01.16.700013v1.13","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.112.269035"},{"key":"2026020608144422000_2026.01.16.700013v1.14","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2019.01.017"},{"key":"2026020608144422000_2026.01.16.700013v1.15","doi-asserted-by":"publisher","DOI":"10.1038\/nature11044"},{"key":"2026020608144422000_2026.01.16.700013v1.16","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(03)00081-0"},{"key":"2026020608144422000_2026.01.16.700013v1.17","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2011.07.020"},{"key":"2026020608144422000_2026.01.16.700013v1.18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8183.2004.04077.x"},{"key":"2026020608144422000_2026.01.16.700013v1.19","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.112.300658"},{"key":"2026020608144422000_2026.01.16.700013v1.20","doi-asserted-by":"publisher","DOI":"10.1038\/nature11739"},{"key":"2026020608144422000_2026.01.16.700013v1.21","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1191-6"},{"key":"2026020608144422000_2026.01.16.700013v1.22","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-03019-z"},{"key":"2026020608144422000_2026.01.16.700013v1.23","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-021-00858-8"},{"key":"2026020608144422000_2026.01.16.700013v1.24","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2019.05.174"},{"key":"2026020608144422000_2026.01.16.700013v1.25","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.117.305962"},{"key":"2026020608144422000_2026.01.16.700013v1.26","doi-asserted-by":"publisher","DOI":"10.1186\/s13578-017-0166-2"},{"key":"2026020608144422000_2026.01.16.700013v1.27","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.310274"},{"key":"2026020608144422000_2026.01.16.700013v1.28","doi-asserted-by":"crossref","unstructured":"Du M , Espinosa-Diez C , Liu M , Ahmed IA , Mahan S , Wei J , Handen AL , Chan SY , Gomez D . miRNA\/mRNA co-profiling identifies the miR-200 family as a central regulator of SMC quiescence. iScience. 2022;25:104169.","DOI":"10.1016\/j.isci.2022.104169"},{"key":"2026020608144422000_2026.01.16.700013v1.29","first-page":"102","article-title":"The mir-200 family regulates key pathogenic events in ascending aortas of individuals with bicuspid aortic","volume":"285","year":"2018","journal-title":"J Intern Med."},{"key":"2026020608144422000_2026.01.16.700013v1.30","doi-asserted-by":"publisher","DOI":"10.1038\/gt.2016.22"},{"key":"2026020608144422000_2026.01.16.700013v1.31","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1177\/0022034517716915","article-title":"Inhibition of the miR-17-92 Cluster Separates Stages of Palatogenesis","volume":"96","year":"2017","journal-title":"J Dent Res"},{"key":"2026020608144422000_2026.01.16.700013v1.32","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1002\/stem.3342","article-title":"The miR-200 family is required for ectodermal organ development through the regulation of the epithelial stem cell niche","volume":"39","year":"2021","journal-title":"Stem Cells"},{"key":"2026020608144422000_2026.01.16.700013v1.33","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1016\/j.omtn.2021.10.021","article-title":"miR-17 acts as a tumor suppressor by negatively regulating the miR-17-92 cluster","volume":"26","year":"2021","journal-title":"Mol Ther Nucleic Acids"},{"key":"2026020608144422000_2026.01.16.700013v1.34","doi-asserted-by":"crossref","first-page":"6947","DOI":"10.1038\/s41467-025-62208-9","article-title":"Single-nuclei multiomics analysis identifies abnormal cardiomyocytes in a murine model of cardiac development","volume":"16","year":"2025","journal-title":"Nat Commun"},{"key":"2026020608144422000_2026.01.16.700013v1.35","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.107.148940"},{"key":"2026020608144422000_2026.01.16.700013v1.36","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000244092.95152.86"},{"key":"2026020608144422000_2026.01.16.700013v1.37","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.101.24.2863"},{"key":"2026020608144422000_2026.01.16.700013v1.38","doi-asserted-by":"publisher","DOI":"10.1242\/dev.089193"},{"key":"2026020608144422000_2026.01.16.700013v1.39","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00459.2021"},{"key":"2026020608144422000_2026.01.16.700013v1.40","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms12260"},{"key":"2026020608144422000_2026.01.16.700013v1.41","doi-asserted-by":"publisher","DOI":"10.1172\/JCI74783"},{"key":"2026020608144422000_2026.01.16.700013v1.42","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2019.01.015"},{"key":"2026020608144422000_2026.01.16.700013v1.43","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-30468-4"},{"key":"2026020608144422000_2026.01.16.700013v1.44","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2013.05.028"},{"key":"2026020608144422000_2026.01.16.700013v1.45","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.11.033"},{"key":"2026020608144422000_2026.01.16.700013v1.46","doi-asserted-by":"publisher","DOI":"10.1038\/nature24045"},{"key":"2026020608144422000_2026.01.16.700013v1.47","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.122.059972"},{"key":"2026020608144422000_2026.01.16.700013v1.48","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.118.314048"},{"key":"2026020608144422000_2026.01.16.700013v1.49","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2011.08.013"},{"key":"2026020608144422000_2026.01.16.700013v1.50","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-02650-6"},{"key":"2026020608144422000_2026.01.16.700013v1.51","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2008.12.010"},{"key":"2026020608144422000_2026.01.16.700013v1.52","doi-asserted-by":"crossref","first-page":"2138","DOI":"10.1016\/j.stemcr.2023.09.014","article-title":"The multi-lineage transcription factor ISL1 controls cardiomyocyte cell fate through interaction with NKX2.5","volume":"18","year":"2023","journal-title":"Stem Cell Reports"},{"key":"2026020608144422000_2026.01.16.700013v1.53","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-007-6520-5"},{"key":"2026020608144422000_2026.01.16.700013v1.54","doi-asserted-by":"publisher","DOI":"10.1016\/S1534-5807(03)00363-0"},{"key":"2026020608144422000_2026.01.16.700013v1.55","doi-asserted-by":"publisher","DOI":"10.1038\/nature08191"},{"key":"2026020608144422000_2026.01.16.700013v1.56","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/s44161-023-00260-8","article-title":"Defining cardiac functional recovery in end-stage heart failure at single-cell resolution","volume":"2","year":"2023","journal-title":"Nat Cardiovasc Res"},{"key":"2026020608144422000_2026.01.16.700013v1.57","doi-asserted-by":"crossref","first-page":"929256","DOI":"10.3389\/fcell.2022.929256","article-title":"Manipulating Cardiomyocyte Plasticity for Heart Regeneration","volume":"10","year":"2022","journal-title":"Front Cell Dev Biol"},{"key":"2026020608144422000_2026.01.16.700013v1.58","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-05060-x"},{"key":"2026020608144422000_2026.01.16.700013v1.59","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1161\/ATVBAHA.122.318333","article-title":"Multiomic Spatial Mapping of Myocardial Infarction and Implications for Personalized Therapy","volume":"43","year":"2023","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2026020608144422000_2026.01.16.700013v1.60","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1983"},{"key":"2026020608144422000_2026.01.16.700013v1.61","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.43882"},{"key":"2026020608144422000_2026.01.16.700013v1.62","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2007.02.009"},{"key":"2026020608144422000_2026.01.16.700013v1.63","doi-asserted-by":"publisher","DOI":"10.1172\/JCI98215"},{"key":"2026020608144422000_2026.01.16.700013v1.64","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/s44161-024-00428-w","article-title":"YAP induces a neonatal-like pro-renewal niche in the adult heart","volume":"3","year":"2024","journal-title":"Nat Cardiovasc Res"},{"key":"2026020608144422000_2026.01.16.700013v1.65","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-021-00668-z"},{"key":"2026020608144422000_2026.01.16.700013v1.66","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1161\/CIRCULATIONAHA.124.072733","article-title":"Cellular Reprogramming by PHF7 Enhances Cardiac Function Following Myocardial Infarctio","volume":"152","year":"2025","journal-title":"Circulation"},{"key":"2026020608144422000_2026.01.16.700013v1.67","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.309589"},{"key":"2026020608144422000_2026.01.16.700013v1.68","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.575654"},{"key":"2026020608144422000_2026.01.16.700013v1.69","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2015.03.011"},{"key":"2026020608144422000_2026.01.16.700013v1.70","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-019-5337-6"},{"key":"2026020608144422000_2026.01.16.700013v1.71","doi-asserted-by":"publisher","DOI":"10.1242\/dev.070151"},{"key":"2026020608144422000_2026.01.16.700013v1.72","first-page":"981","article-title":"Long noncoding RNA lncARSR promotes epithelial ovarian cancer cell proliferation and invasion by association with HuR and miR-200 family","volume":"8","year":"2018","journal-title":"Am J Cancer Res"},{"key":"2026020608144422000_2026.01.16.700013v1.73","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2009.08.009"},{"key":"2026020608144422000_2026.01.16.700013v1.74","doi-asserted-by":"publisher","DOI":"10.1186\/s11658-019-0152-2"},{"key":"2026020608144422000_2026.01.16.700013v1.75","doi-asserted-by":"publisher","DOI":"10.1038\/nature22979"},{"key":"2026020608144422000_2026.01.16.700013v1.76","doi-asserted-by":"crossref","first-page":"84","DOI":"10.15283\/ijsc18102","article-title":"Effect of Substrate Topography and Chemistry on Human Mesenchymal Stem Cell Markers: A Transcriptome Study","volume":"12","year":"2019","journal-title":"Int J Stem Cells"},{"key":"2026020608144422000_2026.01.16.700013v1.77","doi-asserted-by":"publisher","DOI":"10.1007\/s12265-020-10006-7"},{"key":"2026020608144422000_2026.01.16.700013v1.78","first-page":"369","article-title":"Neutrophil membrane-camouflaged nanoparticles alleviate inflammation and promote angiogenesis in ischemic myocardial injury","volume":"23","year":"2022","journal-title":"Bioact Mater"},{"key":"2026020608144422000_2026.01.16.700013v1.79","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.123.065294"},{"key":"2026020608144422000_2026.01.16.700013v1.80","doi-asserted-by":"publisher","DOI":"10.26508\/lsa.202201870"}],"container-title":[],"original-title":[],"link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.64898\/2026.01.16.700013","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T16:14:54Z","timestamp":1770394494000},"score":1,"resource":{"primary":{"URL":"http:\/\/biorxiv.org\/lookup\/doi\/10.64898\/2026.01.16.700013"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,18]]},"references-count":80,"URL":"https:\/\/doi.org\/10.64898\/2026.01.16.700013","relation":{},"subject":[],"published":{"date-parts":[[2026,1,18]]},"subtype":"preprint"}}