{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T03:54:36Z","timestamp":1769572476103,"version":"3.49.0"},"posted":{"date-parts":[[2026,1,23]]},"group-title":"Oncology","reference-count":41,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T00:00:00Z","timestamp":1769126400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.medrxiv.org\/about\/FAQ#license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,1,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Metabolomic changes related to colorectal cancer (CRC) may serve as diagnostic markers to identify patients may develop or have developed CRC.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Untargeted lipidomics were performed on serum from CRC cases and clean-colon controls from the Chicago Colorectal Cancer Consortium (CCCC) and the University of Arizona Cancer Center (UACC).<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Untargeted lipidomics in the CCCC CRC series revealed significant alterations in sphingolipids. Targeted lipidomics revealed a signature of five sphingomyelins (SMs) were significantly decreased in CRC patients in CCCC and UACC CRC series. Circulating SMs are degraded primarily by S-SMase and serum S-SMase activity was significantly higher in UACC cases as compared to controls. Serum S-SMase activity was also measured in two series of adenoma patients to determine if S-SMase may serve as a biomarker for development of colorectal neoplasia. While S-SMase activity was significantly higher in adenoma patients compared to controls in the mostly white UACC series, S-SMase activity in samples from the Chicago Black series (CCCC) were indistinguishable from each other and significantly higher than UACC controls.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Together, these studies suggest the potential for S-SMase activity to serve as a biomarker for colorectal neoplasia, with potential implications in some but perhaps not all populations.<\/jats:p>\n                <\/jats:sec>","DOI":"10.64898\/2026.01.22.26344557","type":"posted-content","created":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T00:10:26Z","timestamp":1769213426000},"source":"Crossref","is-referenced-by-count":0,"title":["Secretory acid sphingomyelinase activity is elevated in persons with colorectal 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USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aki","family":"Hara","sequence":"additional","affiliation":[{"name":"School of Nutritional Sciences and Wellness, College of Agriculture, Life and Environmental Sciences, The University of Arizona, Tucson, AZ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiuming","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Nutritional Sciences and Wellness, College of Agriculture, Life and Environmental Sciences, The University of Arizona, Tucson, AZ, USA"},{"name":"University of Arizona Cancer Center, The University of Arizona, Tucson, AZ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6559-8184","authenticated-orcid":false,"given":"Juanita L.","family":"Merchant","sequence":"additional","affiliation":[{"name":"University of Arizona Cancer Center, The University of Arizona, Tucson, AZ, USA"},{"name":"Department of Medicine 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