{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,8,16]],"date-time":"2026-08-16T07:17:53Z","timestamp":1786864673241,"version":"build-2736575974"},"posted":{"date-parts":[[2026,1,26]]},"group-title":"Gastroenterology","reference-count":33,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T00:00:00Z","timestamp":1769385600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"award":["MH137443"],"award-info":[{"award-number":["MH137443"]}],"id":[{"id":"https:\/\/ror.org\/04xeg9z08","id-type":"ROR","asserted-by":"publisher"}]},{"award":["MH135466"],"award-info":[{"award-number":["MH135466"]}],"id":[{"id":"https:\/\/ror.org\/04xeg9z08","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"Department of Veterans Affairs","doi-asserted-by":"crossref","award":["RCS 19-333"],"award-info":[{"award-number":["RCS 19-333"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,6,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To determine the national prevalence of Cannabinoid Hyperemesis Syndrome (CHS) symptoms and associated characteristics.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Using data from a nationally representative survey of 7,034 US adults (conducted May-September 2025), we fit separate survey-weighted multinomial logistic regression models with a four-category CHS symptom and cannabis use group variable as the outcome and demographic characteristics, cannabis use behaviors, and cannabis-related problems as predictors.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Overall, 2.7% of all respondents and 17.8% of respondents who used cannabis daily reported CHS-like symptoms. Respondents who were younger, female, identified as non-White, had lower income, had lower educational attainment, and endorsed cannabis-related use problems were more likely to be in the CHS symptom group than in the daily cannabis use group.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>CHS symptoms are not uncommon in the US and those with fewer economic resources and more cannabis-related use problems were more likely to report these symptoms, even compared to others with daily cannabis use.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Policy implications<\/jats:title>\n                  <jats:p>As cannabis use increases, CHS is also likely to become more common, underscoring the importance of expanded education about the identification and treatment of CHS.<\/jats:p>\n                <\/jats:sec>","DOI":"10.64898\/2026.01.25.26344780","type":"posted-content","created":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T23:56:23Z","timestamp":1769471783000},"source":"Crossref","is-referenced-by-count":4,"title":["Prevalence and Correlates of Symptoms of Cannabinoid Hyperemesis Syndrome in the United States"],"prefix":"10.64898","author":[{"given":"Mark A.","family":"Ilgen","sequence":"first","affiliation":[{"name":"Addiction Center, Department of Psychiatry, University of Michigan, Ann Arbor, MI"},{"name":"Center for Clinical Management Research, Department of Veterans Affairs, Ann Arbor VA Healthcare System, Ann Arbor, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda M.","family":"Price","sequence":"additional","affiliation":[{"name":"Addiction Center, Department of Psychiatry, University of Michigan, Ann Arbor, MI"},{"name":"Center for Clinical Management Research, Department of Veterans Affairs, Ann Arbor VA Healthcare System, Ann Arbor, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Goldman","sequence":"additional","affiliation":[{"name":"Addiction Center, Department of Psychiatry, University of Michigan, Ann Arbor, MI"},{"name":"Department of Pediatrics, University of Michigan, Ann Arbor, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blair J.","family":"Whittington","sequence":"additional","affiliation":[{"name":"Addiction Center, Department of Psychiatry, University of Michigan, Ann Arbor, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9528-6771","authenticated-orcid":false,"given":"Brian M.","family":"Hicks","sequence":"additional","affiliation":[{"name":"Addiction Center, Department of Psychiatry, University of Michigan, Ann Arbor, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"issue":"25","key":"2026061604201093000_2026.01.25.26344780v2.1","first-page":"597","article-title":"Prevalence of cannabis use around the world: A systematic review and meta-analysis, 2000\u20132024","volume":"6","year":"2024","journal-title":"China CDC weekly"},{"key":"2026061604201093000_2026.01.25.26344780v2.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.dadr.2024.100253"},{"key":"2026061604201093000_2026.01.25.26344780v2.3","doi-asserted-by":"publisher","DOI":"10.1111\/add.16519"},{"key":"2026061604201093000_2026.01.25.26344780v2.4","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2003.036350"},{"issue":"3","key":"2026061604201093000_2026.01.25.26344780v2.5","doi-asserted-by":"crossref","first-page":"e14895","DOI":"10.1111\/nmo.14895","article-title":"Cannabis use patterns and association with hyperemesis: A comprehensive review","volume":"37","year":"2025","journal-title":"Neurogastroenterology & Motility"},{"issue":"11","key":"2026061604201093000_2026.01.25.26344780v2.6","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.3390\/ph17111549","article-title":"A comprehensive review and update on cannabis hyperemesis syndrome","volume":"17","year":"2024","journal-title":"Pharmaceuticals"},{"issue":"17","key":"2026061604201093000_2026.01.25.26344780v2.7","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1001\/jama.2024.9716","article-title":"Cannabinoid hyperemesis syndrome","volume":"332","year":"2024","journal-title":"Jama"},{"key":"2026061604201093000_2026.01.25.26344780v2.8","doi-asserted-by":"crossref","unstructured":"Jim\u00e9nez-Castillo R , Arumugam S , Remes-Troche J , Venkatesan T. 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