{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T02:56:02Z","timestamp":1784948162360,"version":"3.55.0"},"posted":{"date-parts":[[2026,1,28]]},"group-title":"Neuroscience","reference-count":101,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.biorxiv.org\/about\/FAQ#license"}],"funder":[{"name":"NIH","award":["R01 NS120182"],"award-info":[{"award-number":["R01 NS120182"]}]},{"name":"NIH grants supporting the Emory National Primate Research Center","award":["P51OD011132"],"award-info":[{"award-number":["P51OD011132"]}]},{"name":"NIH grants supporting the Emory National Primate Research Center","award":["U42OD011023"],"award-info":[{"award-number":["U42OD011023"]}]},{"name":"Emory NPRC Genomics Core","award":["RRID:SCR_026418"],"award-info":[{"award-number":["RRID:SCR_026418"]}]},{"name":"Emory NPRC Genomics Core","award":["NIH P51 OD011132"],"award-info":[{"award-number":["NIH P51 OD011132"]}]},{"name":"Emory NPRC Genomics Core","award":["NIH S10 OD026799"],"award-info":[{"award-number":["NIH S10 OD026799"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,1,28]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                <jats:p>Congenital and early-life Zika virus (ZIKV) infection can result in neurologic deficits. Precise mechanisms of injury, especially in the more subtle presentation of postnatal infection, are not fully elucidated. Here, we defined the effects of ZIKV on the developing brain using single cell transcriptomics, histopathology and design-based stereology, diffusion MRI, and neurobehavioral assessments in infant rhesus macaques. ZIKV upregulated interferon-stimulated genes in activated microglia and cell death pathways in neurons and downregulated metabolism and differentiation genes in mature oligodendrocytes. Abnormal micro-organization of the corpus collosum and limbic white matter tracts was seen on diffusion weighted imaging. A curated gene set associated with autism spectrum disorder risk was negatively enriched in inhibitory and excitatory neurons from ZIKV-infected infants, with increased emotional reactivity already evident two weeks following infection. From single cells to organism-level behaviors, these results define the pathways and processes disrupted by early-life ZIKV infection.<\/jats:p>","DOI":"10.64898\/2026.01.26.701807","type":"posted-content","created":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T07:40:14Z","timestamp":1769672414000},"source":"Crossref","is-referenced-by-count":2,"title":["Mechanisms of disrupted neurodevelopment after Zika virus infection in infancy"],"prefix":"10.64898","author":[{"given":"Venkata-Viswanadh","family":"Edara","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sienna","family":"Freeman","sequence":"additional","affiliation":[{"name":"Emory National Primate Research Center, Atlanta, Georgia, 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