{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T09:10:08Z","timestamp":1770109808775,"version":"3.49.0"},"posted":{"date-parts":[[2026,1,30]]},"group-title":"Gastroenterology","reference-count":44,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:00:00Z","timestamp":1769731200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.medrxiv.org\/about\/FAQ#license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,1,30]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                <jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>\n                    Previous studies have shown that Aquamin\n                    <jats:sup>\u00ae<\/jats:sup>\n                    , a multi-mineral extract from red marine algae, enhances barrier integrity proteins in the human colon. These findings prompted further investigation into Aquamin\n                    <jats:sup>\u00ae<\/jats:sup>\n                    \u2019s effects on gastrointestinal barrier function and permeability.\n                  <\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>\n                    Subjects with mild or in remission ulcerative colitis (UC) and healthy controls were enrolled in an open-label trial and received Aquamin\n                    <jats:sup>\u00ae<\/jats:sup>\n                    capsules (800 mg calcium\/day) for 90 days. Intestinal permeability was evaluated before and after the 90-day intervention by urinary mannitol excretion after ingestion of a 5 g mannitol solution, with collections across several time intervals (pre-drink, 0\u20132 h, 2\u20138 h, and 8\u201324 h). The primary outcome was the change in mannitol excretion. Serum samples were also collected to assess liver and renal function.\n                  <\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>\n                    In this pilot study (\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"clintrialgov\" xlink:href=\"NCT04855799\">NCT04855799<\/jats:ext-link>\n                    ), which included UC patients and healthy controls (n = 8 per group), baseline urine mannitol levels in the 0\u20132 h sample were 54% higher in UC patients compared to healthy subjects (p = 0.006). Following 90 days of Aquamin\n                    <jats:sup>\u00ae<\/jats:sup>\n                    supplementation, urinary mannitol levels in UC patients decreased by 28%, 26%, and 41% at the 0\u20132 h, 2\u20138 h, and 8\u201324 h timepoints, respectively; the reduction at the 0\u20132 h interval reached statistical significance (p = 0.015). Overall, Aquamin\n                    <jats:sup>\u00ae<\/jats:sup>\n                    supplementation reduced total post-intervention mannitol excretion by 29% (p = 0.024). Aquamin\n                    <jats:sup>\u00ae<\/jats:sup>\n                    was well tolerated, with no serious adverse events reported. The serum metabolic panel revealed a modest but statistically significant reduction in alkaline phosphatase levels after 90 days of intervention.\n                  <\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>\n                    These results provide preliminary evidence that Aquamin\n                    <jats:sup>\u00ae<\/jats:sup>\n                    supplementation beneficially modulates gut barrier function and supports epithelial integrity in UC patients. These findings support further investigation of Aquamin\n                    <jats:sup>\u00ae<\/jats:sup>\n                    as a safe and promising adjunct to current UC management strategies, with potential utility as a barrier therapy in UC.\n                  <\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Aquamin\n                    <jats:sup>\u00ae<\/jats:sup>\n                    supplementation for 90 days reduced intestinal permeability in ulcerative colitis patients, as measured by urinary mannitol excretion. The intervention was well tolerated, suggesting Aquamin\n                    <jats:sup>\u00ae<\/jats:sup>\n                    may be a safe, promising adjunct for enhancing gut barrier function in UC management.\n                  <\/jats:p>\n                <\/jats:sec>","DOI":"10.64898\/2026.01.28.26345064","type":"posted-content","created":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T23:25:21Z","timestamp":1769815521000},"source":"Crossref","is-referenced-by-count":0,"title":["A Multi-Mineral Intervention Improves Intestinal Permeability in Patients with Ulcerative Colitis: Results from a 90-Day Pilot Trial"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1361-5357","authenticated-orcid":false,"given":"Muhammad N.","family":"Aslam","sequence":"first","affiliation":[{"name":"Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, United States of America"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danielle 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