{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T09:03:18Z","timestamp":1785402198299,"version":"3.56.0"},"posted":{"date-parts":[[2026,2,2]]},"group-title":"Immunology","reference-count":102,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T00:00:00Z","timestamp":1769990400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"funder":[{"id":[{"id":"https:\/\/ror.org\/006w34k90","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Harvard Center for AIDS Research","award":["P30 AI060354"],"award-info":[{"award-number":["P30 AI060354"]}]},{"name":"Mark and Lisa Schwartz Foundation"},{"name":"Philip and Susan Ragon Foundation"},{"name":"Witten Family Foundation"},{"name":"Sub-Saharan African Network for TB\/HIV Research Excellence"},{"DOI":"10.13039\/100000865","name":"Bill & Melinda Gates Foundation","doi-asserted-by":"crossref","award":["INV-033558"],"award-info":[{"award-number":["INV-033558"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100005564","name":"Gilead Sciences Inc.","doi-asserted-by":"crossref","award":["19275"],"award-info":[{"award-number":["19275"]}],"id":[{"id":"10.13039\/100005564","id-type":"DOI","asserted-by":"crossref"}]},{"name":"NIH Director\u2019s New Innovator Award","award":["DP2-AI158126"],"award-info":[{"award-number":["DP2-AI158126"]}]},{"name":"Koch Institute Support (core) Grant","award":["P30-CA14051"],"award-info":[{"award-number":["P30-CA14051"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,2,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>\n                  Virus-specific CD8\n                  <jats:sup>+<\/jats:sup>\n                  T cells are crucial in controlling chronic human viral infections such as HIV-1, but the effect of persistent antigen exposure on T cell repertoire formation is not well understood. In this study, we examined epitope-specific CD8\n                  <jats:sup>+<\/jats:sup>\n                  T cell repertoires in people living with HIV-1, where duration of viremia following hyperacute infection was modulated by the time of initiation of continuous suppressive antiretroviral therapy (ART). After ART-induced undetectable viremia in persons expressing the same HLA class I allele, we analyzed the impact of early (n=6) versus delayed (n=6) ART initiation on the clonotypic composition, clonotypic cross-reactivity, functional avidity and memory differentiation profile of the HIV-specific T cell repertoire restricted by HLA-B*58:01. Using a panel of barcoded tetramers, we mapped T cell receptor (TCR) clonotypes specific for three dominant epitopes and their variants. Both groups exhibited polyclonal TCR repertoires with evidence of cross-reactivity, which was significantly enriched in donors with prolonged antigen exposure. Within this cohort, broadly cross-reactive clonotypes capable of recognizing all autologous variants were identified, but these were rare (&lt;1%). Early ART initiation preserved repertoires characterized by higher-avidity TCRs and a relative enrichment of transitional memory CD8\n                  <jats:sup>+<\/jats:sup>\n                  T cell subsets. These functional differences were not associated with differences in TRBV gene sharing, indicating that ART timing shapes repertoire quality and memory differentiation without altering TRBV gene bias. These findings demonstrate how antigen suppression dynamics differentially shape the breadth, functional sensitivity, and memory composition of the HIV-specific TCR repertoire, with implications for T cell-directed immunotherapies and HIV cure strategies.\n                <\/jats:p>\n                <jats:sec>\n                  <jats:title>One Sentence Summary<\/jats:title>\n                  <jats:p>The duration of viral antigen exposure during early HIV infection shapes the functional quality, breadth, and memory composition of virus-specific CD8\u207a T cell receptor repertoires.<\/jats:p>\n                  <jats:fig id=\"ufig1\" position=\"float\" orientation=\"portrait\" fig-type=\"figure\">\n                    <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"702605v1_ufig1\" position=\"float\" orientation=\"portrait\"\/>\n                  <\/jats:fig>\n                <\/jats:sec>","DOI":"10.64898\/2026.01.29.702605","type":"posted-content","created":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T18:15:19Z","timestamp":1770056119000},"source":"Crossref","is-referenced-by-count":0,"title":["Duration of Initial Viremia Modulates Functional Properties of HIV-specific T Cell Receptors"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5655-4905","authenticated-orcid":false,"given":"Funsho J.","family":"Ogunshola","sequence":"first","affiliation":[{"name":"Ragon Institute of Mass General Brigham, MIT, and Harvard, Cambridge, MA, 02139, USA"},{"name":"Massachusetts Institute of Technology, Cambridge, MA 02169, USA"},{"name":"Howard Hughes Medical Institute, Chevy Chase, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nishant K.","family":"Singh","sequence":"additional","affiliation":[{"name":"Ragon Institute of Mass General Brigham, MIT, and Harvard, Cambridge, MA, 02139, USA"},{"name":"Massachusetts Institute of Technology, Cambridge, MA 02169, USA"},{"name":"Howard Hughes Medical Institute, Chevy Chase, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Butty","sequence":"additional","affiliation":[{"name":"Massachusetts Institute of Technology, Cambridge, MA 02169, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anurag R.","family":"Mishra","sequence":"additional","affiliation":[{"name":"Ragon Institute of Mass General Brigham, MIT, and Harvard, Cambridge, MA, 02139, USA"},{"name":"Massachusetts Institute of Technology, Cambridge, MA 02169, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zacharia","family":"Habte","sequence":"additional","affiliation":[{"name":"Ragon Institute of Mass General Brigham, MIT, and Harvard, Cambridge, MA, 02139, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liza","family":"Vecchiarello","sequence":"additional","affiliation":[{"name":"Ragon Institute of Mass General Brigham, MIT, and Harvard, Cambridge, MA, 02139, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Fahad","sequence":"additional","affiliation":[{"name":"Ragon Institute of Mass General Brigham, MIT, and Harvard, Cambridge, MA, 02139, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate B.","family":"Juergens","sequence":"additional","affiliation":[{"name":"Ragon Institute of Mass General Brigham, MIT, and Harvard, Cambridge, MA, 02139, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia","family":"Cheever","sequence":"additional","affiliation":[{"name":"Ragon Institute of Mass General Brigham, MIT, and Harvard, Cambridge, MA, 02139, USA"},{"name":"Massachusetts Institute of Technology, Cambridge, MA 02169, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marius","family":"Allombert","sequence":"additional","affiliation":[{"name":"Ragon Institute of Mass General Brigham, MIT, and Harvard, Cambridge, MA, 02139, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anabelle","family":"Webber","sequence":"additional","affiliation":[{"name":"Ragon Institute of Mass General Brigham, MIT, and Harvard, Cambridge, MA, 02139, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicja","family":"Piechocka-Trocha","sequence":"additional","affiliation":[{"name":"Ragon Institute of Mass General Brigham, MIT, and Harvard, Cambridge, MA, 02139, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nasreen","family":"Ismail","sequence":"additional","affiliation":[{"name":"HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZulu-Natal, 4013 Durban, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anusha","family":"Nathan","sequence":"additional","affiliation":[{"name":"Ragon Institute of Mass General Brigham, MIT, and Harvard, Cambridge, MA, 02139, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolong","family":"Li","sequence":"additional","affiliation":[{"name":"Ragon Institute of Mass General Brigham, MIT, and Harvard, Cambridge, MA, 02139, USA"},{"name":"University of Science and Technology of China, Hefei 230001, Anhui, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kavidha","family":"Reddy","sequence":"additional","affiliation":[{"name":"Africa Health Research Institute, Durban, 4013, South Africa"},{"name":"HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZulu-Natal, 4013 Durban, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamini","family":"Gounder","sequence":"additional","affiliation":[{"name":"Africa Health Research Institute, Durban, 4013, South Africa"},{"name":"HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZulu-Natal, 4013 Durban, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omolara O.","family":"Baiyegunhi","sequence":"additional","affiliation":[{"name":"Africa Health Research Institute, Durban, 4013, South Africa"},{"name":"HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZulu-Natal, 4013 Durban, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David R.","family":"Collins","sequence":"additional","affiliation":[{"name":"Ragon Institute of Mass General Brigham, MIT, and Harvard, Cambridge, MA, 02139, USA"},{"name":"Howard Hughes Medical Institute, Chevy Chase, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Musie","family":"Ghebremichael","sequence":"additional","affiliation":[{"name":"Ragon Institute of Mass General Brigham, MIT, and Harvard, Cambridge, MA, 02139, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaurav","family":"Gaiha","sequence":"additional","affiliation":[{"name":"Ragon Institute of Mass General Brigham, MIT, and Harvard, Cambridge, MA, 02139, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krista","family":"Dong","sequence":"additional","affiliation":[{"name":"Ragon Institute of Mass General Brigham, MIT, and Harvard, Cambridge, MA, 02139, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandon J.","family":"Dekosky","sequence":"additional","affiliation":[{"name":"Ragon Institute of Mass General Brigham, MIT, and Harvard, Cambridge, MA, 02139, USA"},{"name":"Massachusetts Institute of Technology, Cambridge, MA 02169, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2962-3992","authenticated-orcid":false,"given":"Thumbi","family":"Ndung\u2019u","sequence":"additional","affiliation":[{"name":"Ragon Institute of Mass General Brigham, MIT, and Harvard, Cambridge, MA, 02139, USA"},{"name":"Africa Health Research Institute, Durban, 4013, South Africa"},{"name":"HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZulu-Natal, 4013 Durban, South Africa"},{"name":"Division of Infection and Immunity, University College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2281-3518","authenticated-orcid":false,"given":"Michael E.","family":"Birnbaum","sequence":"additional","affiliation":[{"name":"Ragon Institute of Mass General Brigham, MIT, and Harvard, Cambridge, MA, 02139, USA"},{"name":"Massachusetts Institute of Technology, Cambridge, MA 02169, USA"},{"name":"Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02169, USA"},{"name":"Kock Institute for Integrative Cancer Research, Cambridge, MA, 02139, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6122-9245","authenticated-orcid":false,"given":"Bruce D.","family":"Walker","sequence":"additional","affiliation":[{"name":"Ragon Institute of Mass General Brigham, MIT, and Harvard, Cambridge, MA, 02139, USA"},{"name":"Massachusetts Institute of Technology, Cambridge, MA 02169, USA"},{"name":"HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZulu-Natal, 4013 Durban, South Africa"},{"name":"Howard Hughes Medical Institute, Chevy Chase, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2026020511485019000_2026.01.29.702605v1.1","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines9091026"},{"key":"2026020511485019000_2026.01.29.702605v1.2","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-022-00753-w"},{"key":"2026020511485019000_2026.01.29.702605v1.3","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(24)00358-X"},{"key":"2026020511485019000_2026.01.29.702605v1.4","doi-asserted-by":"publisher","DOI":"10.3390\/cells12101351"},{"key":"2026020511485019000_2026.01.29.702605v1.5","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-020-0274-9"},{"key":"2026020511485019000_2026.01.29.702605v1.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.01.007"},{"key":"2026020511485019000_2026.01.29.702605v1.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2020.103118"},{"key":"2026020511485019000_2026.01.29.702605v1.8","doi-asserted-by":"publisher","DOI":"10.1126\/science.aav5095"},{"key":"2026020511485019000_2026.01.29.702605v1.9","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06331-x"},{"key":"2026020511485019000_2026.01.29.702605v1.10","doi-asserted-by":"publisher","DOI":"10.1126\/science.283.5403.857"},{"key":"2026020511485019000_2026.01.29.702605v1.11","doi-asserted-by":"publisher","DOI":"10.1084\/jem.189.6.991"},{"key":"2026020511485019000_2026.01.29.702605v1.12","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20060928"},{"key":"2026020511485019000_2026.01.29.702605v1.13","doi-asserted-by":"publisher","DOI":"10.1038\/nri3905"},{"key":"2026020511485019000_2026.01.29.702605v1.14","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0801125"},{"key":"2026020511485019000_2026.01.29.702605v1.15","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro974"},{"key":"2026020511485019000_2026.01.29.702605v1.16","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-02-206557"},{"key":"2026020511485019000_2026.01.29.702605v1.17","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0029717"},{"key":"2026020511485019000_2026.01.29.702605v1.18","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20051357"},{"key":"2026020511485019000_2026.01.29.702605v1.19","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00460-11"},{"key":"2026020511485019000_2026.01.29.702605v1.20","doi-asserted-by":"publisher","DOI":"10.1126\/science.adg0514"},{"key":"2026020511485019000_2026.01.29.702605v1.21","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20070784"},{"key":"2026020511485019000_2026.01.29.702605v1.22","doi-asserted-by":"publisher","DOI":"10.1172\/JCI41538"},{"key":"2026020511485019000_2026.01.29.702605v1.23","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2010.06.005"},{"key":"2026020511485019000_2026.01.29.702605v1.24","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-020-0628-2"},{"key":"2026020511485019000_2026.01.29.702605v1.25","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3018(17)30146-7"},{"key":"2026020511485019000_2026.01.29.702605v1.26","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aau0528"},{"key":"2026020511485019000_2026.01.29.702605v1.27","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.08.012"},{"key":"2026020511485019000_2026.01.29.702605v1.28","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aau2798"},{"key":"2026020511485019000_2026.01.29.702605v1.29","unstructured":"in Guidelines for Managing Advanced HIV Disease and Rapid Initiation of Antiretroviral Therapy (World Health Organization Copyright \u00a9 World Health Organization 2017., 2017)."},{"key":"2026020511485019000_2026.01.29.702605v1.30","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01847-06"},{"key":"2026020511485019000_2026.01.29.702605v1.31","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02265-08"},{"key":"2026020511485019000_2026.01.29.702605v1.32","doi-asserted-by":"publisher","DOI":"10.1038\/nature03113"},{"key":"2026020511485019000_2026.01.29.702605v1.33","doi-asserted-by":"publisher","DOI":"10.1038\/nm1520"},{"key":"2026020511485019000_2026.01.29.702605v1.34","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-200309050-00005"},{"key":"2026020511485019000_2026.01.29.702605v1.35","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3018(17)30146-7"},{"key":"2026020511485019000_2026.01.29.702605v1.36","unstructured":"Alamos, L. HIV T cell Epitope sequences. https:\/\/www.hiv.lanl.gov\/content\/immunology\/tables\/ctl_summary.html (2000)."},{"key":"2026020511485019000_2026.01.29.702605v1.37","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.109378"},{"key":"2026020511485019000_2026.01.29.702605v1.38","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00239-09"},{"key":"2026020511485019000_2026.01.29.702605v1.39","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-07209-7"},{"key":"2026020511485019000_2026.01.29.702605v1.40","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2013.01.006"},{"key":"2026020511485019000_2026.01.29.702605v1.41","doi-asserted-by":"publisher","DOI":"10.1111\/imm.12499"},{"key":"2026020511485019000_2026.01.29.702605v1.42","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.05.031"},{"key":"2026020511485019000_2026.01.29.702605v1.43","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-12464-3"},{"key":"2026020511485019000_2026.01.29.702605v1.44","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-27150-6"},{"key":"2026020511485019000_2026.01.29.702605v1.45","doi-asserted-by":"publisher","DOI":"10.1038\/srep12264"},{"key":"2026020511485019000_2026.01.29.702605v1.46","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1016350108"},{"key":"2026020511485019000_2026.01.29.702605v1.47","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-020-0791-5"},{"key":"2026020511485019000_2026.01.29.702605v1.48","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2022.104253"},{"key":"2026020511485019000_2026.01.29.702605v1.49","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-15375-w"},{"key":"2026020511485019000_2026.01.29.702605v1.50","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2021.08.007"},{"key":"2026020511485019000_2026.01.29.702605v1.51","unstructured":"Support., x. G. Understanding Single Cell technologies: Barcodes and UMIs. 10x Genomics https:\/\/help.geneiousbiologics.com\/hc\/en-us\/articles\/4781289585300-Understanding-Single-Cell-technologies-Barcodes-and-UMIs?utm_source=chatgpt.com (2022)."},{"key":"2026020511485019000_2026.01.29.702605v1.52","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-018-1603-1"},{"key":"2026020511485019000_2026.01.29.702605v1.53","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.81810"},{"key":"2026020511485019000_2026.01.29.702605v1.54","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-0716-2712-9_8"},{"key":"2026020511485019000_2026.01.29.702605v1.55","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1005572"},{"key":"2026020511485019000_2026.01.29.702605v1.56","doi-asserted-by":"publisher","DOI":"10.1159\/000445656"},{"key":"2026020511485019000_2026.01.29.702605v1.57","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2342"},{"key":"2026020511485019000_2026.01.29.702605v1.58","doi-asserted-by":"publisher","DOI":"10.1016\/j.coviro.2016.01.017"},{"key":"2026020511485019000_2026.01.29.702605v1.59","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2024.114555"},{"key":"2026020511485019000_2026.01.29.702605v1.60","doi-asserted-by":"publisher","DOI":"10.1109\/18.61115"},{"key":"2026020511485019000_2026.01.29.702605v1.61","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01500"},{"key":"2026020511485019000_2026.01.29.702605v1.62","doi-asserted-by":"publisher","DOI":"10.1084\/jem.165.4.1141"},{"key":"2026020511485019000_2026.01.29.702605v1.63","doi-asserted-by":"crossref","first-page":"13342","DOI":"10.1016\/S0021-9258(18)45206-4","article-title":"Internalization and cycling of the T cell antigen receptor. Role of protein kinase C","volume":"262","year":"1987","journal-title":"J Biol Chem"},{"key":"2026020511485019000_2026.01.29.702605v1.64","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2004.09.008"},{"key":"2026020511485019000_2026.01.29.702605v1.65","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20101574"},{"key":"2026020511485019000_2026.01.29.702605v1.66","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1101734"},{"key":"2026020511485019000_2026.01.29.702605v1.67","doi-asserted-by":"publisher","DOI":"10.1126\/science.274.5284.94"},{"key":"2026020511485019000_2026.01.29.702605v1.68","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01388-06"},{"key":"2026020511485019000_2026.01.29.702605v1.69","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.CIR-22-0761"},{"key":"2026020511485019000_2026.01.29.702605v1.70","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.b.20496"},{"key":"2026020511485019000_2026.01.29.702605v1.71","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.1991.tb08168.x"},{"key":"2026020511485019000_2026.01.29.702605v1.72","doi-asserted-by":"publisher","DOI":"10.1111\/cas.15776"},{"key":"2026020511485019000_2026.01.29.702605v1.73","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0137393"},{"key":"2026020511485019000_2026.01.29.702605v1.74","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.67092"},{"key":"2026020511485019000_2026.01.29.702605v1.75","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adm8951"},{"key":"2026020511485019000_2026.01.29.702605v1.76","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-024-02044-z"},{"key":"2026020511485019000_2026.01.29.702605v1.77","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.7.3309"},{"key":"2026020511485019000_2026.01.29.702605v1.78","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.600829"},{"key":"2026020511485019000_2026.01.29.702605v1.79","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms13848"},{"key":"2026020511485019000_2026.01.29.702605v1.80","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.122795"},{"key":"2026020511485019000_2026.01.29.702605v1.81","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-021-01503-6"},{"key":"2026020511485019000_2026.01.29.702605v1.82","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-025-09932-w"},{"key":"2026020511485019000_2026.01.29.702605v1.83","doi-asserted-by":"publisher","DOI":"10.21203\/rs.3.rs-6141479\/v1"},{"key":"2026020511485019000_2026.01.29.702605v1.84","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiy479"},{"key":"2026020511485019000_2026.01.29.702605v1.85","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003211"},{"key":"2026020511485019000_2026.01.29.702605v1.86","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1900811"},{"key":"2026020511485019000_2026.01.29.702605v1.87","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-44389-3"},{"key":"2026020511485019000_2026.01.29.702605v1.88","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-10659-2"},{"key":"2026020511485019000_2026.01.29.702605v1.89","doi-asserted-by":"publisher","DOI":"10.1002\/psc.2836"},{"key":"2026020511485019000_2026.01.29.702605v1.90","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-38573-8"},{"key":"2026020511485019000_2026.01.29.702605v1.91","doi-asserted-by":"publisher","DOI":"10.1016\/j.jim.2016.02.016"},{"key":"2026020511485019000_2026.01.29.702605v1.92","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-025-01238-2"},{"key":"2026020511485019000_2026.01.29.702605v1.93","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-11049-4"},{"key":"2026020511485019000_2026.01.29.702605v1.94","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkn316"},{"key":"2026020511485019000_2026.01.29.702605v1.95","doi-asserted-by":"publisher","DOI":"10.1101\/pdb.prot5633"},{"key":"2026020511485019000_2026.01.29.702605v1.96","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.4096"},{"key":"2026020511485019000_2026.01.29.702605v1.97","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.2000.4042"},{"key":"2026020511485019000_2026.01.29.702605v1.98","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btl529"},{"key":"2026020511485019000_2026.01.29.702605v1.99","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkae268"},{"key":"2026020511485019000_2026.01.29.702605v1.100","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.886683"},{"key":"2026020511485019000_2026.01.29.702605v1.101","doi-asserted-by":"publisher","DOI":"10.1093\/protein\/gzab034"},{"key":"2026020511485019000_2026.01.29.702605v1.102","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-31858-4"}],"container-title":[],"original-title":[],"link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.64898\/2026.01.29.702605","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T19:49:01Z","timestamp":1770320941000},"score":1,"resource":{"primary":{"URL":"http:\/\/biorxiv.org\/lookup\/doi\/10.64898\/2026.01.29.702605"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,2]]},"references-count":102,"URL":"https:\/\/doi.org\/10.64898\/2026.01.29.702605","relation":{},"subject":[],"published":{"date-parts":[[2026,2,2]]},"subtype":"preprint"}}