{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T21:15:34Z","timestamp":1783199734523,"version":"3.54.6"},"posted":{"date-parts":[[2026,2,2]]},"group-title":"Neuroscience","reference-count":94,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T00:00:00Z","timestamp":1769990400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Office of Mental Health of Rockland County, NY","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"crossref","award":["U19 AG024904"],"award-info":[{"award-number":["U19 AG024904"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:sec>\n                  <jats:title>INTRODUCTION<\/jats:title>\n                  <jats:p>Astrocyte reactivity may contribute to increased Alzheimer\u2019s disease (AD) risk in women. Although higher plasma glial fibrillary acidic protein (GFAP) levels have been reported in women, few studies have investigated sex-specific relationships with other plasma AD biomarkers and cognition.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>Participants were enrolled in the Memory Education and Research Initiative, a longitudinal community-based cohort, and underwent evaluation including blood biomarker sampling. The Alzheimer\u2019s Disease Neuroimaging Initiative (ADNI) was included as a replication cohort.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Unimpaired women exhibited higher plasma GFAP levels than men (N=584). Higher baseline GFAP was associated with worse longitudinal episodic memory, exclusively in women. In addition, both higher baseline and increasing GFAP levels over time were associated with lower longitudinal plasma A\u03b242\/40 ratio. The key results were replicated in the ADNI cohort.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>DISCUSSION<\/jats:title>\n                  <jats:p>These findings suggest that astrocytic reactivity is more pronounced in women and may contribute to sex-specific vulnerability to AD-related pathology and cognitive decline.<\/jats:p>\n                <\/jats:sec>","DOI":"10.64898\/2026.01.30.702902","type":"posted-content","created":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T06:20:17Z","timestamp":1770099617000},"source":"Crossref","is-referenced-by-count":1,"title":["Sex-specific associations between astrocytic reactivity and cognitive decline in unimpaired elderly"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9662-6179","authenticated-orcid":false,"given":"Chelsea Reichert","family":"Plaska","sequence":"first","affiliation":[{"name":"Geriatric Psychiatry Division, Nathan S. Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA"},{"name":"Department of Psychiatry, NYU Grossman School of Medicine, 145 E 32nd Street, New York, NY 10016, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tovia","family":"Jacobs","sequence":"additional","affiliation":[{"name":"Penn State College of Medicine, 700 HMC Cres Rd, Hershey, PA 17033, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1943-9905","authenticated-orcid":false,"given":"Davide","family":"Bruno","sequence":"additional","affiliation":[{"name":"School of Psychology, Liverpool John Moores University, Tom Reilly building, L3 3AF, Liverpool, UK"},{"name":"Department of Communication Sciences and Disorders, University of Wisconsin, 1308 W. Dayton St., Madison, WI 53715, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Han","family":"Lee","sequence":"additional","affiliation":[{"name":"Center for Dementia Research, Nathan S. Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA"},{"name":"Department of Psychiatry, NYU Grossman School of Medicine, 145 E 32nd Street, New York, NY 10016, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno P.","family":"Imbimbo","sequence":"additional","affiliation":[{"name":"Department of Research & Development, Chiesi Farmaceutici, Largo Francesco Belloli 11\/a, 43122 Parma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo S.","family":"Osorio","sequence":"additional","affiliation":[{"name":"Clinical Research Department, Nathan S. Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962"},{"name":"Department of Psychiatry, NYU Grossman School of Medicine, 145 E 32nd St\\reet, New York, NY 10016, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9a L.","family":"Benedet","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurochemistry, Institute of Neuroscience & Physiology, the Sahlgrenska Academy at the University of Gothenburg, SE-Wallinsgatan 6, 43141 M\u00f6lndal, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas J.","family":"Ashton","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurochemistry, Institute of Neuroscience & Physiology, the Sahlgrenska Academy at the University of Gothenburg, SE-Wallinsgatan 6, 43141 M\u00f6lndal, Sweden"},{"name":"Banner Alzheimer\u2019s Institute and University of Arizona, 901 E. 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