{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T19:32:38Z","timestamp":1792179158104,"version":"4.4.0"},"posted":{"date-parts":[[2026,2,3]]},"group-title":"Immunology","reference-count":127,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"award":["R01AG068142"],"award-info":[{"award-number":["R01AG068142"]}],"id":[{"id":"https:\/\/ror.org\/01cwqze88","id-type":"ROR","asserted-by":"publisher"}]},{"award":["5T32MH019524-31"],"award-info":[{"award-number":["5T32MH019524-31"]}],"id":[{"id":"https:\/\/ror.org\/01cwqze88","id-type":"ROR","asserted-by":"publisher"}]},{"award":["5T32NS086750-08"],"award-info":[{"award-number":["5T32NS086750-08"]}],"id":[{"id":"https:\/\/ror.org\/01cwqze88","id-type":"ROR","asserted-by":"publisher"}]},{"award":["R01NS122316"],"award-info":[{"award-number":["R01NS122316"]}],"id":[{"id":"https:\/\/ror.org\/01cwqze88","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,2,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>\n                  Brain-resident macrophages are known to play numerous roles in the progression of Alzheimer\u2019s Disease (AD). However, the relative contribution of microglia and border-associated macrophages (BAM) to AD pathogenesis has been difficult to disentangle. We recently identified\n                  <jats:italic>Maf<\/jats:italic>\n                  , a newly described AD GWAS gene, as essential for BAM, but not microglial, survival. By crossing BAM depleted mice with the 5xFAD AD model, we found stark evidence of cerebral amyloid angiopathy (CAA), increased overall \u03b2-amyloid burden, accelerated markers of neurodegeneration, and early memory deficits. In the healthy brain, BAM take up more \u03b2-amyloid per cell than microglia. However, as disease progresses, both in human AD patient samples and model AD mice, BAM number is reduced, and the remaining BAMs display impaired endocytic capacity, and show signs of metabolic exhaustion at an earlier age than microglia. Thus, strategies to preserve or restore BAM function represents a novel therapeutic avenue for AD and CAA.\n                <\/jats:p>","DOI":"10.64898\/2026.01.31.703045","type":"posted-content","created":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T22:40:15Z","timestamp":1770158415000},"source":"Crossref","is-referenced-by-count":6,"title":["Functional border-associated macrophages limit Alzheimer\u2019s Disease progression"],"prefix":"10.64898","author":[{"given":"Drew","family":"Adler","sequence":"first","affiliation":[{"name":"Vilcek Institute of Graduate Biomedical Sciences, New York University Grossman School of Medicine; New York, NY, USA"},{"name":"Department of Cell Biology; New York University Grossman School of Medicine, New York, NY, USA"},{"name":"Department of Neuroscience and Physiology, New York University Grossman School of Medicine; New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nat\u00e1lia","family":"Pinheiro-Rosa","sequence":"additional","affiliation":[{"name":"Department of Cell Biology; New York University Grossman School of Medicine, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alon","family":"Millet","sequence":"additional","affiliation":[{"name":"Laboratory of Systems Cancer Biology, The Rockefeller University; New York, NY, USA"},{"name":"Tri-Institutional Program in Computational Biology and Medicine, The Rockefeller University; New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoran Z","family":"Gajic","sequence":"additional","affiliation":[{"name":"Vilcek Institute of Graduate Biomedical Sciences, New York University Grossman School of Medicine; New York, NY, USA"},{"name":"Department of Neuroscience and Physiology, New York University Grossman School of Medicine; New York, NY, USA"},{"name":"New York Genome Center; New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evan","family":"Cheng","sequence":"additional","affiliation":[{"name":"New York University Grossman School of Medicine; New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bego\u00f1a","family":"Gamallo-Lana","sequence":"additional","affiliation":[{"name":"Department of Neuroscience and Physiology, Neuroscience Institute, New York University Grossman School of Medicine; New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yosuke","family":"Morizawa","sequence":"additional","affiliation":[{"name":"Center for Neural Science, New York University, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7379-6802","authenticated-orcid":false,"given":"Eric","family":"Klann","sequence":"additional","affiliation":[{"name":"Department of Neuroscience and Physiology, New York University Grossman School of Medicine; New York, NY, USA"},{"name":"Center for Neural Science, New York University, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Biao","family":"Gan","sequence":"additional","affiliation":[{"name":"Institute of Neurological and Psychiatric Disorders, Shenzhen Bay Laboratory, Shenzhen, 518132, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam C","family":"Mar","sequence":"additional","affiliation":[{"name":"Department of Neuroscience and Physiology, Neuroscience Institute, New York University Grossman School of Medicine; New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose H.","family":"Ledo","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Department of Pathology and Laboratory of Medicine, South Carolina Alzheimer\u2019s Disease Research Center, Medical University of South Carolina; Charleston, SC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hernandez","family":"Moura Silva","sequence":"additional","affiliation":[{"name":"Laboratory of Immunophysiology, Ragon Institute of Mass General, MIT, and Harvard; Cambridge, MA, USA"},{"name":"Department of Biology, Massachusetts Institute of Technology; Cambridge, MA, USA"},{"name":"Howard Hughes Medical Institute; Cambridge, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan J.","family":"Lafaille","sequence":"additional","affiliation":[{"name":"Department of Cell Biology; New York University Grossman School of Medicine, New York, NY, USA"},{"name":"Department of Pathology, New York University Grossman School of Medicine; New York, NY, 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