{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T06:03:15Z","timestamp":1782280995558,"version":"3.54.5"},"posted":{"date-parts":[[2026,2,7]]},"group-title":"Pathology","reference-count":43,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T00:00:00Z","timestamp":1770422400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.biorxiv.org\/about\/FAQ#license"}],"funder":[{"name":"The Intramural Research Program of the NIH, The National Institute of Diabetes and Digestive and Kidney Diseases"},{"name":"The Japan Society for the Promotion of Science Research Fellowship for Japanese Biomedical and Behavioral Researchers at NIH","award":["72207"],"award-info":[{"award-number":["72207"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,2,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>\n                  Class B scavenger receptors BI (SR-BI) and BII (SR-BII) internalize lipoproteins but also bind and internalize bacteria. Their roles in sepsis are unknown. We overexpressed human SR-BI and BII in the liver and kidney as well as bone marrow-derived macrophages, and then performed cecal ligation and puncture (CLP) surgery. SR-BI and BII transgenic mice had significantly worse survival compared to WT mice. 24 h after CLP, liver injury markers and histological damage were prominent in both SR-BI and BII transgenic mice, whereas kidney damage was similar. Systemic inflammatory cytokines were markedly increased in SR-BI and BII transgenic mice; parallel increases were seen in liver mRNA expression, not in the kidney. The highest degree of neutrophil infiltration was observed in the liver of SR-BI. Human SR-BI and BII dramatically decreased bacterial accumulation in the liver. Green fluorescence protein-labeled\n                  <jats:italic>E. coli<\/jats:italic>\n                  were efficiently phagocytosed in hepatic macrophages of SR-BI and BII transgenic mice; phagocytosis was more prominent in SR-BII transgenic mice. Finally, human SR-BI overexpression reduced systemic HDL-C level, eliminated adrenal cortex lipid droplets, and dampened the systemic increase of corticosterone after CLP. Supplementation with glucocorticoid and mineralocorticoid improved survival in SR-BI, but not SR-BII, transgenic mice after CLP. In summary, our findings suggest human SR-BI and BII overexpression contributes to higher mortality after CLP by excessive inflammatory response due to adrenal insufficiency (SR-BI) or hyperactive phagocytosis (SR-BII) in the liver.\n                <\/jats:p>","DOI":"10.64898\/2026.02.04.703853","type":"posted-content","created":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T02:35:11Z","timestamp":1770518111000},"source":"Crossref","is-referenced-by-count":0,"title":["Different functions of human scavenger receptors BI and BII overexpressed in a murine abdominal sepsis model"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-7257-7670","authenticated-orcid":false,"given":"Naoki","family":"Hayase","sequence":"first","affiliation":[{"name":"Renal Diagnostics and Therapeutics Unit, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, 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