{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T13:13:58Z","timestamp":1788441238213,"version":"build-2803163510"},"posted":{"date-parts":[[2026,2,6]]},"group-title":"Infectious Diseases (except HIV\/AIDS)","reference-count":30,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T00:00:00Z","timestamp":1770336000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"crossref","award":["R35GM128648"],"award-info":[{"award-number":["R35GM128648"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"crossref"}]},{"award":["UL1TR002319"],"award-info":[{"award-number":["UL1TR002319"]}],"id":[{"id":"https:\/\/ror.org\/01cp21a44","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,8,31]]},"abstract":"<jats:title>Structured Abstract<\/jats:title>\n                <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>When leveraged for longitudinal studies, remote sampling with transcriptomic readouts is a powerful tool for studying host immune response. Remote study flexibility circumvents common barriers to research participation including transportation and scheduling. We investigated the effectiveness of a remote design for reaching women from underrepresented, underserved, and underreported (U3) populations per the NIH definition.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>U3 women positive for COVID-19 were tracked over the course of 6 months. Participants self-collected nasal and homeRNA-stabilized blood samples. homeRNA is a platform for remote self-collection of blood samples with RNA stabilization. Five samplings were completed in 25 days (month 1). A subset of participants likely to develop post-acute sequelae of COVID-19 (PASC) and their age-matched controls were selected for extended sampling (month 3). All participants were resurveyed at months 4, 5, and 6 about their symptoms.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>\n                    Forty participants were fully enrolled in the study, and 39 completed all study components. Survey responses show high satisfaction in the study, where all participants who completed the study (\n                    <jats:italic>n<\/jats:italic>\n                    = 39\/39) indicated they would be willing to participate in a similar study again, with most (\n                    <jats:italic>n<\/jats:italic>\n                    = 32\/39) indicating a willingness to participate for up to 4 years with around 15 samples collected per year.\n                  <\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>\n                    The high participant retention (\n                    <jats:italic>n<\/jats:italic>\n                    = 39\/40) and satisfaction in this study indicates the utility of a remote study design for longitudinal research. We also find that study topic, flexibility of sampling, and positive interactions with the study team are important factors for participant recruitment and retention.\n                  <\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Summary<\/jats:title>\n                  <jats:p>40 U3 women who tested positive for SARS-CoV-2 were tracked over 6 months with blood selfsampling. High retention and positive participant experience suggest that the increased flexibility of a fully remote design facilitates participation of individuals who may otherwise be excluded from clinical research.<\/jats:p>\n                <\/jats:sec>","DOI":"10.64898\/2026.02.05.26345688","type":"posted-content","created":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T01:30:23Z","timestamp":1770427823000},"source":"Crossref","is-referenced-by-count":1,"title":["Research In Your Mailbox: Remote Blood Sampling Enables Longitudinal Studies in Underserved Groups"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1448-9578","authenticated-orcid":false,"given":"Filip","family":"Stefanovic","sequence":"first","affiliation":[{"name":"Department of Chemistry, University of Washington, Seattle, WA, 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