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In this study, we established a high-resolution\n                  <jats:sup>23<\/jats:sup>\n                  Na-MRI platform based on 14 T preclinical scanner using a dual-tuned head-implanted RF coil. This configuration enables the acquisition of\n                  <jats:sup>1<\/jats:sup>\n                  H-based T\n                  <jats:sub>2<\/jats:sub>\n                  -weighted anatomical and diffusion-weighted imaging (DWI), as well as\n                  <jats:sup>23<\/jats:sup>\n                  Na-MRI, from the same animal. Brain-wide\n                  <jats:sup>23<\/jats:sup>\n                  Na-MRI with 300\u00d7300 \u00b5m\n                  <jats:sup>2<\/jats:sup>\n                  in-plane resolution was performed within the first 4 hours after acute middle cerebral artery occlusion (MCAO) induced ischemic stroke induction. Hyperintense\n                  <jats:sup>23<\/jats:sup>\n                  Na-MRI signals were observed in the ischemic brain regions, presenting a contrast-to-noise ratio (CNR) that exceeded that of T\n                  <jats:sub>2<\/jats:sub>\n                  -weighted images. Infarct regions can be well-identified in the elevated\n                  <jats:sup>23<\/jats:sup>\n                  Na signal, which is spatially consistent with regions of reduced apparent diffusion coefficient (ADC) values, indicating water restriction in the ischemic core. This work established implanted double-tuned\n                  <jats:sup>1<\/jats:sup>\n                  H\/\n                  <jats:sup>23<\/jats:sup>\n                  Na RF coils as a powerful approach for high-resolution\n                  <jats:sup>23<\/jats:sup>\n                  Na-MRI readout, facilitating the early detection of ischemic brain injury.\n                <\/jats:p>","DOI":"10.64898\/2026.02.05.703829","type":"posted-content","created":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T18:10:18Z","timestamp":1770747018000},"source":"Crossref","is-referenced-by-count":1,"title":["High spatial resolution\n                  <sup>23<\/sup>\n                  Na-MRI for ischemic brain injury detection"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7758-7450","authenticated-orcid":false,"given":"Yuanyuan","family":"Jiang","sequence":"first","affiliation":[{"name":"Athinoula A. 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