{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T17:35:16Z","timestamp":1770831316418,"version":"3.50.1"},"posted":{"date-parts":[[2026,2,9]]},"group-title":"Psychiatry and Clinical Psychology","reference-count":62,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T00:00:00Z","timestamp":1770595200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,2,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:sec>\n                  <jats:title>INTRODUCTION<\/jats:title>\n                  <jats:p>Cognitive decline in Alzheimer\u2019s disease (AD) may arise not only from neuronal loss but also from disrupted temporal coordination across distributed networks. Prior works in healthy individuals has shown memory-related modulation of hippocampal\u2013cortical phase\u2013amplitude coupling (PAC). We hypothesized alteration of resting-state hippocampo-cortical PAC in AD which relates to cognitive impairment.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>Resting-state magnetoencephalography (MEG) data were obtained from 78 AD patients and 70 healthy controls. Source-reconstructed hippocampal and cortical signals were analysed using antisymmetrized bispectral methods to quantify non-linear across-site PAC.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>AD patients showed significant disruptions of hippocampo-cortical PAC, particularly involving frontal, parahippocampal, and posterior-cingulate cortices. PAC measures were significantly associated with Mini-Mental State Examination scores within the AD group, with higher PAC corresponding to greater cognitive impairment in regions showing increased coupling relative to controls.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>DISCUSSION<\/jats:title>\n                  <jats:p>These findings demonstrate altered hippocampo-cortical temporal coordination in AD and suggest PAC as a potential electrophysiological marker of disease-related network dysfunction.<\/jats:p>\n                <\/jats:sec>","DOI":"10.64898\/2026.02.06.26345635","type":"posted-content","created":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T17:25:15Z","timestamp":1770657915000},"source":"Crossref","is-referenced-by-count":0,"title":["Abnormal hippocampo-cortical theta-gamma phase-amplitude coupling in Alzheimer\u2019s disease"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-8406-4401","authenticated-orcid":false,"given":"Erfan","family":"Baradarantohidi","sequence":"first","affiliation":[{"name":"Technische Universit\u00e4t Berlin, 10623 Berlin, Germany"},{"name":"Physikalisch-Technische Bundesanstalt, 10587 Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7209-3857","authenticated-orcid":false,"given":"Srikantan S","family":"Nagarajan","sequence":"additional","affiliation":[{"name":"Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94158, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4217-8785","authenticated-orcid":false,"given":"Kamalini G","family":"Ranasinghe","sequence":"additional","affiliation":[{"name":"Memory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA 94158, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1470-9195","authenticated-orcid":false,"given":"Stefan","family":"Haufe","sequence":"additional","affiliation":[{"name":"Technische Universit\u00e4t Berlin, 10623 Berlin, Germany"},{"name":"Physikalisch-Technische Bundesanstalt, 10587 Berlin, Germany"},{"name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin, 10117 Berlin, Germany"},{"name":"Bernstein Center for Computational Neuroscience, 10115 Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"54368","reference":[{"key":"2026021108462074000_2026.02.06.26345635v1.1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.70235"},{"key":"2026021108462074000_2026.02.06.26345635v1.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2006.09.020"},{"key":"2026021108462074000_2026.02.06.26345635v1.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2004.01.001"},{"key":"2026021108462074000_2026.02.06.26345635v1.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2009.04.003"},{"key":"2026021108462074000_2026.02.06.26345635v1.5","doi-asserted-by":"publisher","DOI":"10.1111\/j.0953-816X.2004.03333.x"},{"key":"2026021108462074000_2026.02.06.26345635v1.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2004.03.008"},{"key":"2026021108462074000_2026.02.06.26345635v1.7","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhj127"},{"key":"2026021108462074000_2026.02.06.26345635v1.8","first-page":"450","article-title":"Biomagnetic biomarkers for dementia: A pilot multicentre study with a recommended methodological framework for magnetoencephalography. 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