{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T20:18:46Z","timestamp":1792181926277,"version":"4.4.0"},"posted":{"date-parts":[[2026,2,9]]},"group-title":"Genetic and Genomic Medicine","reference-count":60,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T00:00:00Z","timestamp":1770595200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,2,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>\n                  Ewing sarcoma (EwS) is a rare, aggressive pediatric malignancy driven by\n                  <jats:italic>FET<\/jats:italic>\n                  ::\n                  <jats:italic>ETS<\/jats:italic>\n                  family fusions (\n                  <jats:italic>EWSR1<\/jats:italic>\n                  ::\n                  <jats:italic>FLI1<\/jats:italic>\n                  in &gt;85% of cases) with no established environmental risk factors. To investigate germline predisposition, we analyzed 2,014 EwS cases and 10,525 cancer-free controls in a two-stage analysis that combined an international genome-wide association study and a case\u25a1parent trio study. The combined meta-analysis identified 18 variants at 14 susceptibility loci (9 novel, 5 replicated) with moderate effect sizes (odds ratios\u22651.25). Integrative analyses of the EwS loci revealed enrichment of expanded GGAA microsatellites, with evidence for binding of the EWSR1\n                  <jats:italic>::<\/jats:italic>\n                  FLI1 chimeric oncogenic activator.\n                  <jats:italic>EWSR1::ETS<\/jats:italic>\n                  knockdown in EwS cell lines resulted in dysregulated genes at susceptibility loci related to skeletal\/muscle development, RNA binding\/processing, and chromatin regulation. Our findings provide insights into the inherited component of EwS, highlighting a genetic architecture in which common germline variations with moderate effects interact with somatic\n                  <jats:italic>EWSR1<\/jats:italic>\n                  ::\n                  <jats:italic>FLI1<\/jats:italic>\n                  fusions to promote sarcomagenesis by dysregulating local genes.\n                <\/jats:p>","DOI":"10.64898\/2026.02.06.26345779","type":"posted-content","created":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T02:40:31Z","timestamp":1770691231000},"source":"Crossref","is-referenced-by-count":1,"title":["Genome-wide association study meta-analysis identifies susceptibility loci informing Ewing sarcoma etiology and potential mechanisms of risk"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4052-1110","authenticated-orcid":false,"given":"Aubrey K.","family":"Hubbard","sequence":"first","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5660-4941","authenticated-orcid":false,"given":"H\u00e9l\u00e8ne","family":"Neyret-Kahn","sequence":"additional","affiliation":[{"name":"INSERM U1330, Children\u2019s Oncology Research Unit, PSL Research University, SIREDO Oncology Center, Institut Curie Research Center, Paris 75005, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"M\u00fcller-Nurasiyd","sequence":"additional","affiliation":[{"name":"Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center, Johannes Gutenberg University, Mainz, Germany"},{"name":"IBE, Faculty of Medicine, LMU Munich, Munich, Germany"},{"name":"Institute of Genetic Epidemiology, Helmholtz Zentrum M\u00fcnchen \u2013 German Research Center for Environmental Health, Neuherberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominik","family":"L\u00f6w","sequence":"additional","affiliation":[{"name":"Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center, Johannes Gutenberg University, Mainz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantin","family":"Strauch","sequence":"additional","affiliation":[{"name":"Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center, Johannes Gutenberg University, Mainz, Germany"},{"name":"IBE, Faculty of Medicine, LMU Munich, Munich, Germany"},{"name":"Institute of Genetic Epidemiology, Helmholtz Zentrum M\u00fcnchen \u2013 German Research Center for Environmental Health, Neuherberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3199-3004","authenticated-orcid":false,"given":"Olivia W.","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7069-6934","authenticated-orcid":false,"given":"Andrew R.","family":"Raduski","sequence":"additional","affiliation":[{"name":"Division of Pediatric Epidemiology & Clinical Research, Pediatrics Department, University of Minnesota, Minneapolis, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0162-7740","authenticated-orcid":false,"given":"Tianzhong","family":"Yang","sequence":"additional","affiliation":[{"name":"Division of Biostatistics and Health Data Science, School of Public Health, University of Minnesota, Minneapolis, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0467-3064","authenticated-orcid":false,"given":"Weiyin","family":"Zhou","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA"},{"name":"Cancer Genomics Research Laboratory, Frederick National Lab for Cancer Research, Frederick, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elliot W.","family":"Stratton","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orson","family":"Jay","sequence":"additional","affiliation":[{"name":"INSERM U1330, Children\u2019s Oncology Research Unit, PSL Research University, SIREDO Oncology Center, Institut Curie Research Center, Paris 75005, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandrine","family":"Grosset\u00eate","sequence":"additional","affiliation":[{"name":"INSERM U1330, Children\u2019s Oncology Research Unit, PSL Research University, SIREDO Oncology Center, Institut Curie Research Center, Paris 75005, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Song","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6634-9040","authenticated-orcid":false,"given":"Diptavo","family":"Dutta","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy A.","family":"Hutchinson","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA"},{"name":"Cancer Genomics Research Laboratory, Frederick National Lab for Cancer Research, Frederick, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Belynda D.","family":"Hicks","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA"},{"name":"Cancer Genomics Research Laboratory, Frederick National Lab for Cancer Research, Frederick, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Manning","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA"},{"name":"Cancer Genomics Research Laboratory, Frederick National Lab for Cancer Research, Frederick, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Liu","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA"},{"name":"Cancer Genomics Research Laboratory, Frederick National Lab for Cancer Research, Frederick, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carrie","family":"Boyce","sequence":"additional","affiliation":[{"name":"Westat, Rockville, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Hartmann","sequence":"additional","affiliation":[{"name":"Gerhard-Domagk-Institute of Pathology, M\u00fcnster University Hospital, M\u00fcnster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uta","family":"Dirksen","sequence":"additional","affiliation":[{"name":"Pediatrics III, West German Cancer Center, National Center for Tumor Diseases (NCT). West, German Cancer Consortium (DKTK) site Essen, University Hospital Essen, Essen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas E.","family":"Kulozik","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology, Hematology and Immunology, Heidelberg University, Clinical Cooperation Unit Pediatric Leukemia, German Cancer Research Center (DKFZ)"},{"name":"Hopp Children\u2019s Cancer Center (KiTZ), Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Metzler","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine, Universit\u00e4tsklinikum Erlangen and Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg, Erlangen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Krumbholz","sequence":"additional","affiliation":[{"name":"Institute of Human Genetics, Helmholtz Zentrum M\u00fcnchen, German Research Center for Environmental Health, Neuherberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8309-094X","authenticated-orcid":false,"given":"Alexander","family":"Teumer","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany"},{"name":"DZHK (German Centre for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry","family":"V\u00f6lzke","sequence":"additional","affiliation":[{"name":"Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uwe","family":"V\u00f6lker","sequence":"additional","affiliation":[{"name":"Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany and DZHK (German Centre for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6968-7694","authenticated-orcid":false,"given":"Joshua D.","family":"Schiffman","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics and Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javed","family":"Khan","sequence":"additional","affiliation":[{"name":"Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6984-2407","authenticated-orcid":false,"given":"Melissa M.","family":"Hudson","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Cancer Control, St. Jude Children\u2019s Research Hospital, Memphis, TN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsten K.","family":"Ness","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Cancer Control, St. Jude Children\u2019s Research Hospital, Memphis, TN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoming","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Cancer Control, St. Jude Children\u2019s Research Hospital, Memphis, TN, USA"},{"name":"Department of Computational Biology, St. Jude Children\u2019s Research Hospital, Memphis, TN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6000-3594","authenticated-orcid":false,"given":"Katherine A.","family":"Janeway","sequence":"additional","affiliation":[{"name":"Dana-Farber\/Boston Children\u2019s Cancer and Blood Disorders Center, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0978-5863","authenticated-orcid":false,"given":"Philip J.","family":"Lupo","sequence":"additional","affiliation":[{"name":"Aflac Cancer and Blood Disorders Center at Children\u2019s Healthcare of Atlanta\/Department of Pediatrics, Emory University, Atlanta, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2516-0222","authenticated-orcid":false,"given":"Logan G.","family":"Spector","sequence":"additional","affiliation":[{"name":"Division of Pediatric Epidemiology & Clinical Research, Pediatrics Department, University of Minnesota, Minneapolis, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Yi","family":"Huang","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven C.","family":"Moore","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2324-3393","authenticated-orcid":false,"given":"Stephen J.","family":"Chanock","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas G.P.","family":"Gr\u00fcnewald","sequence":"additional","affiliation":[{"name":"Hopp Children\u2019s Cancer Center (KiTZ), Heidelberg, Germany"},{"name":"Division of Translational Pediatric Sarcoma Research, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), 69120 Heidelberg, Germany"},{"name":"Institute of Pathology, Heidelberg University Hospital, 69120 Heidelberg, Germany"},{"name":"National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Delattre","sequence":"additional","affiliation":[{"name":"INSERM U1330, Children\u2019s Oncology Research Unit, PSL Research University, SIREDO Oncology Center, Institut Curie Research Center, Paris 75005, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6538-9705","authenticated-orcid":false,"given":"Mitchell J.","family":"Machiela","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2026021105402225000_2026.02.06.26345779v1.1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.33674"},{"key":"2026021105402225000_2026.02.06.26345779v1.2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24388"},{"key":"2026021105402225000_2026.02.06.26345779v1.3","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-018-0041-4"},{"key":"2026021105402225000_2026.02.06.26345779v1.4","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.59.5256"},{"key":"2026021105402225000_2026.02.06.26345779v1.5","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djq278"},{"key":"2026021105402225000_2026.02.06.26345779v1.6","doi-asserted-by":"publisher","DOI":"10.1038\/359162a0"},{"key":"2026021105402225000_2026.02.06.26345779v1.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2023.01.017"},{"key":"2026021105402225000_2026.02.06.26345779v1.8","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0004932"},{"key":"2026021105402225000_2026.02.06.26345779v1.9","doi-asserted-by":"publisher","DOI":"10.1038\/nature12213"},{"key":"2026021105402225000_2026.02.06.26345779v1.10","doi-asserted-by":"publisher","DOI":"10.1038\/nature25480"},{"key":"2026021105402225000_2026.02.06.26345779v1.11","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1004475"},{"key":"2026021105402225000_2026.02.06.26345779v1.12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2022.04.007"},{"key":"2026021105402225000_2026.02.06.26345779v1.13","doi-asserted-by":"publisher","DOI":"10.1126\/science.adq0071"},{"key":"2026021105402225000_2026.02.06.26345779v1.14","doi-asserted-by":"publisher","DOI":"10.1038\/ng.1085"},{"key":"2026021105402225000_2026.02.06.26345779v1.15","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-05537-2"},{"key":"2026021105402225000_2026.02.06.26345779v1.16","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0801073105"},{"key":"2026021105402225000_2026.02.06.26345779v1.17","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.22.3339"},{"key":"2026021105402225000_2026.02.06.26345779v1.18","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6603474"},{"key":"2026021105402225000_2026.02.06.26345779v1.19","doi-asserted-by":"publisher","DOI":"10.1177\/003335491312800508"},{"key":"2026021105402225000_2026.02.06.26345779v1.20","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyaa203"},{"issue":"9","key":"2026021105402225000_2026.02.06.26345779v1.21","first-page":"1415","article-title":"Risk of non-Hodgkin\u2019s lymphoma and family history of lymphatic, hematologic, and other cancers","volume":"13","year":"2004","journal-title":"Cancer Epidemiol Biomark Prev Publ Am Assoc Cancer Res Cosponsored Am Soc Prev Oncol"},{"key":"2026021105402225000_2026.02.06.26345779v1.22","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-2456(00)00098-2"},{"key":"2026021105402225000_2026.02.06.26345779v1.23","doi-asserted-by":"publisher","DOI":"10.1038\/s41597-022-01921-2"},{"key":"2026021105402225000_2026.02.06.26345779v1.24","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyac034"},{"key":"2026021105402225000_2026.02.06.26345779v1.25","doi-asserted-by":"publisher","DOI":"10.1093\/jncics\/pkad079"},{"key":"2026021105402225000_2026.02.06.26345779v1.26","unstructured":"Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program | Nature. November 22, 2024. Accessed November 22, 2024. https:\/\/www.nature.com\/articles\/s41586-021-03205-y"},{"key":"2026021105402225000_2026.02.06.26345779v1.27","doi-asserted-by":"publisher","DOI":"10.1038\/nature15393"},{"key":"2026021105402225000_2026.02.06.26345779v1.28","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3656"},{"key":"2026021105402225000_2026.02.06.26345779v1.29","unstructured":"kf-alignment-workflow\/docs\/KFDRC_GATK_HAPLOTYPECALLER_CRAM_TO_GVCF_WORKFLOW_R EADME.md at master \u00b7 kids-first\/kf-alignment-workflow. GitHub. Accessed January 7, 2025. https:\/\/github.com\/kids-first\/kf-alignment-workflow\/blob\/master\/docs\/KFDRC_GATK_HAPLOTYPECALLER_CRAM_TO_GVCF_WORKFLOW_README.md"},{"key":"2026021105402225000_2026.02.06.26345779v1.30","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.0020190"},{"key":"2026021105402225000_2026.02.06.26345779v1.31","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0002551"},{"key":"2026021105402225000_2026.02.06.26345779v1.32","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btaa784"},{"key":"2026021105402225000_2026.02.06.26345779v1.33","doi-asserted-by":"publisher","DOI":"10.1534\/g3.118.200925"},{"key":"2026021105402225000_2026.02.06.26345779v1.34","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2011.04.014"},{"key":"2026021105402225000_2026.02.06.26345779v1.35","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btq340"},{"key":"2026021105402225000_2026.02.06.26345779v1.36","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2213"},{"key":"2026021105402225000_2026.02.06.26345779v1.37","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2010.11.011"},{"key":"2026021105402225000_2026.02.06.26345779v1.38","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.111761"},{"key":"2026021105402225000_2026.02.06.26345779v1.39","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abo3789"},{"key":"2026021105402225000_2026.02.06.26345779v1.40","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3363"},{"key":"2026021105402225000_2026.02.06.26345779v1.41","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1701872114"},{"key":"2026021105402225000_2026.02.06.26345779v1.42","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2021.04.001"},{"key":"2026021105402225000_2026.02.06.26345779v1.43","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2008-9-9-r137"},{"key":"2026021105402225000_2026.02.06.26345779v1.44","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkac747"},{"key":"2026021105402225000_2026.02.06.26345779v1.45","doi-asserted-by":"publisher","DOI":"10.1016\/j.cancergen.2012.04.004"},{"key":"2026021105402225000_2026.02.06.26345779v1.46","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2017.49"},{"key":"2026021105402225000_2026.02.06.26345779v1.47","doi-asserted-by":"publisher","DOI":"10.1111\/his.13689"},{"issue":"11","key":"2026021105402225000_2026.02.06.26345779v1.48","first-page":"2869","article-title":"Fusion of PAX7 to FKHR by the variant t(1;13)(p36;q14) translocation in alveolar rhabdomyosarcoma","volume":"54","year":"1994","journal-title":"Cancer Res"},{"key":"2026021105402225000_2026.02.06.26345779v1.49","doi-asserted-by":"publisher","DOI":"10.1101\/gad.12.17.2735"},{"key":"2026021105402225000_2026.02.06.26345779v1.50","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23105589"},{"key":"2026021105402225000_2026.02.06.26345779v1.51","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-023-04700-8"},{"key":"2026021105402225000_2026.02.06.26345779v1.52","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S199667"},{"issue":"3","key":"2026021105402225000_2026.02.06.26345779v1.53","first-page":"1554","article-title":"MEX3C promotes osteosarcoma malignant progression through negatively regulating FGF14","volume":"25","year":"2020","journal-title":"J BUON Off J Balk Union Oncol"},{"key":"2026021105402225000_2026.02.06.26345779v1.54","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkz1238"},{"key":"2026021105402225000_2026.02.06.26345779v1.55","doi-asserted-by":"publisher","DOI":"10.3389\/FIMMU.2023.1115794\/BIBTEX"},{"key":"2026021105402225000_2026.02.06.26345779v1.56","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.007401"},{"key":"2026021105402225000_2026.02.06.26345779v1.57","doi-asserted-by":"publisher","DOI":"10.3390\/cells11233922"},{"key":"2026021105402225000_2026.02.06.26345779v1.58","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.210.Supp.169.07"},{"key":"2026021105402225000_2026.02.06.26345779v1.59","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-08-0667"},{"key":"2026021105402225000_2026.02.06.26345779v1.60","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.959868"}],"container-title":[],"original-title":[],"link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.64898\/2026.02.06.26345779","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T13:40:39Z","timestamp":1770817239000},"score":1,"resource":{"primary":{"URL":"http:\/\/medrxiv.org\/lookup\/doi\/10.64898\/2026.02.06.26345779"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,9]]},"references-count":60,"URL":"https:\/\/doi.org\/10.64898\/2026.02.06.26345779","relation":{},"subject":[],"published":{"date-parts":[[2026,2,9]]},"subtype":"preprint"}}