{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T20:12:20Z","timestamp":1781554340688,"version":"3.54.5"},"posted":{"date-parts":[[2026,2,9]]},"group-title":"Immunology","reference-count":137,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T00:00:00Z","timestamp":1770595200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["AI110508"],"award-info":[{"award-number":["AI110508"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["AI53365"],"award-info":[{"award-number":["AI53365"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["AI150664"],"award-info":[{"award-number":["AI150664"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["AI152476"],"award-info":[{"award-number":["AI152476"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["AI125180"],"award-info":[{"award-number":["AI125180"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,2,9]]},"abstract":"<jats:title>SUMMARY<\/jats:title>\n                <jats:p>\n                  Interferon regulatory factor 1 (IRF1), a transcription factor encoded within the 5q31 locus harboring systemic lupus erythematosus (SLE) associated variants, promotes inflammatory responses by T and myeloid cells. Although IFN\u03b3-activated B cells also express IRF1, its role in B cell biology and SLE is unclear. Here, we use a mouse SLE model, single-cell multiomics, and human B cells to show that IRF1 intrinsically regulates\n                  <jats:italic>Irf4<\/jats:italic>\n                  gene chromatin accessibility and expression in B cells to control the balance between the antibody secreting cell (ASC) lineage commitment factor, IRF4, and the B cell identity factor, IRF8. We demonstrate that IRF1, through its integration of IFN\u03b3 and TLR7 induced transcriptional programs, tips B cells toward a terminal effector inflammatory AC fate at the expense of preserving more stem-like, resting and regulatory B cells that do not elicit autoantibody-associated pathology in SLE. Thus, IRF1 serves as a central node controlling B cell-driven autoimmune disease.\n                <\/jats:p>","DOI":"10.64898\/2026.02.06.704376","type":"posted-content","created":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T23:10:14Z","timestamp":1770678614000},"source":"Crossref","is-referenced-by-count":1,"title":["IFN\u03b3-induced IRF1 synergizes with TLR7 signals to tune the IRF4-IRF8 axis and drive pathogenic effector B cell fate"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4499-0678","authenticated-orcid":false,"given":"Eddie-Williams","family":"Owiredu","sequence":"first","affiliation":[{"name":"Department of Microbiology, The University of Alabama at Birmingham, Birmingham, AL 35294, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9997-0765","authenticated-orcid":false,"given":"Ashley J.","family":"Denslow","sequence":"additional","affiliation":[{"name":"Department of Microbiology, The University of Alabama at Birmingham, Birmingham, AL 35294, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suki","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Microbiology, The University of Alabama at Birmingham, Birmingham, AL 35294, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Betty","family":"Mousseau","sequence":"additional","affiliation":[{"name":"Department of Microbiology, The University of Alabama at Birmingham, Birmingham, AL 35294, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6621-6096","authenticated-orcid":false,"given":"Jeremy B.","family":"Foote","sequence":"additional","affiliation":[{"name":"Department of Microbiology, The University of Alabama at Birmingham, Birmingham, AL 35294, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6103-8836","authenticated-orcid":false,"given":"Guang","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Microbiology, The University of Alabama at Birmingham, Birmingham, AL 35294, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1894-8882","authenticated-orcid":false,"given":"Jessica N.","family":"Peel","sequence":"additional","affiliation":[{"name":"Department of Microbiology, The University of Alabama at Birmingham, Birmingham, AL 35294, USA"},{"name":"St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, 10065, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4426-8757","authenticated-orcid":false,"given":"Rebecca","family":"Burnham","sequence":"additional","affiliation":[{"name":"Department of Microbiology, The University of Alabama at Birmingham, Birmingham, AL 35294, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6267-0492","authenticated-orcid":false,"given":"Kelsey","family":"Browning","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Clinical Immunology and Rheumatology, The University of Alabama at Birmingham, Birmingham, AL, 35294 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7716-8504","authenticated-orcid":false,"given":"Christopher D.","family":"Scharer","sequence":"additional","affiliation":[{"name":"Dept of Microbiology and Immunology, Emory University, Atlanta, GA 30322, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0643-0311","authenticated-orcid":false,"given":"Troy D.","family":"Randall","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Clinical Immunology and Rheumatology, The University of Alabama at Birmingham, Birmingham, AL, 35294 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7631-7114","authenticated-orcid":false,"given":"Esther","family":"Zumaquero-Martinez","sequence":"additional","affiliation":[{"name":"Department of Microbiology, The University of Alabama at Birmingham, Birmingham, AL 35294, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3083-1246","authenticated-orcid":false,"given":"Frances E.","family":"Lund","sequence":"additional","affiliation":[{"name":"Department of Microbiology, The University of Alabama at Birmingham, Birmingham, AL 35294, 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