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By combining multi-trait, machine learning and single-cell transcriptomics with genotyping data for BMI and T2D, we investigate how these traits converge on shared genetic pathways to AD risk. Variant-level analyses reveal AD risk associates with genetically-driven hypotension and hypoglycaemia. We identify sixteen high-confidence effector genes in seven independent loci colocalizing between BMI\/T2D and AD, mapping primarily to peripheral immune-metabolic tissues and cell-types. Eight high-confidence risk genes are currently targeted by ongoing therapeutic programmes, substantiating translatability relevance. Exploratory approaches using sex- and age-stratified genotyping data for BMI and T2D pinpoints potential sex-specific cardiometabolic liability linked to higher BMI-associated risk in women and T2D-driven risk in men. These findings elucidate shared cardiometabolic correlates with AD, prioritizes biological pathways, and reveal computationally-nominated drug candidates for preclinical testing.<\/jats:p>","DOI":"10.64898\/2026.02.10.26344393","type":"posted-content","created":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T16:15:26Z","timestamp":1770912926000},"source":"Crossref","is-referenced-by-count":0,"title":["Genomics link obesity and type 2 diabetes to Alzheimer\u2019s disease to unveil novel biological insights"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3811-2932","authenticated-orcid":false,"given":"C\u00e9sar","family":"Cunha","sequence":"first","affiliation":[{"name":"Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, 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Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9669-5147","authenticated-orcid":false,"given":"Maria Victoria","family":"Fernandez","sequence":"additional","affiliation":[{"name":"Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya (UIC), Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4461-3568","authenticated-orcid":false,"given":"Ole A.","family":"Andreassen","sequence":"additional","affiliation":[{"name":"Centre for Precision Psychiatry, Institute of Clinical Medicine, University of Oslo, Oslo, Norway"},{"name":"Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway"},{"name":"KG Jebsen Centre for Neurodevelopmental disorders, University of Oslo, Oslo, 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