{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T15:40:47Z","timestamp":1785426047966,"version":"3.56.0"},"posted":{"date-parts":[[2026,2,12]]},"group-title":"Neuroscience","reference-count":78,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T00:00:00Z","timestamp":1770854400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"award":["NS112424"],"award-info":[{"award-number":["NS112424"]}],"id":[{"id":"https:\/\/ror.org\/01cwqze88","id-type":"ROR","asserted-by":"publisher"}]},{"award":["NS117406"],"award-info":[{"award-number":["NS117406"]}],"id":[{"id":"https:\/\/ror.org\/01cwqze88","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Weill Institute for Neuroscience at UCSF"},{"name":"Weill Neurohub","award":["Weill Neurohub Pillars"],"award-info":[{"award-number":["Weill Neurohub Pillars"]}]},{"name":"Weill Neurohub","award":["Weill Neurohub Fellows Program"],"award-info":[{"award-number":["Weill Neurohub Fellows Program"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,2,12]]},"abstract":"<jats:title>\n                  S\n                  <jats:sc>ummary<\/jats:sc>\n                <\/jats:title>\n                <jats:p>Although somatosensation is known to be important for precise hand control, how coordinated activity across sensory and motor cortical areas supports hand movements and object interactions is unclear. We simultaneously recorded neural activity from dorsal premotor cortex (PMd) and Area 2 of the primary somatosensory cortex in three rhesus macaques performing a reach-to-grasp task during recovery from a primary motor cortex (M1) lesion. Using dual-area latent factor analysis, we decomposed population activity into cross-area factors (CFs) shared between PMd and Area 2 and within-area factors (WFs) local to each region. Shared CFs tracked hand kinematics closely despite explaining less overall variance. Strikingly, the emergence of long-timescale, stereotyped sensory\u2013motor cross-area dynamics was correlated with recovery of prehension and object grasping, whereas changes in within-area dynamics were not correlated with recovery. These findings suggest that restoration of coordinated sensory\u2013motor population dynamics is important for recovery of skilled hand function after injury.<\/jats:p>","DOI":"10.64898\/2026.02.10.705199","type":"posted-content","created":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T23:00:14Z","timestamp":1770937214000},"source":"Crossref","is-referenced-by-count":0,"title":["Shared somatosensory\u2013motor neural population dynamics track motor recovery after stroke"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4821-7888","authenticated-orcid":false,"given":"Ian S.","family":"Heimbuch","sequence":"first","affiliation":[{"name":"Department of Neurology, University of California, San Francisco; San Francisco, CA 94158, USA"},{"name":"California National Primate Research Center, University of California, Davis; Davis, CA 95616, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6402-6486","authenticated-orcid":false,"given":"Preeya","family":"Khanna","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of California, San Francisco; San Francisco, CA 94158, USA"},{"name":"California National Primate Research Center, University of California, Davis; Davis, CA 95616, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Novik","sequence":"additional","affiliation":[{"name":"California National Primate Research Center, University of California, Davis; Davis, CA 95616, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"Morecraft","sequence":"additional","affiliation":[{"name":"Laboratory of Neurological Sciences, Division of Basic Biomedical Sciences, Sanford School of Medicine, The University of South Dakota; Vermillion, SD 57069, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2570-9943","authenticated-orcid":false,"given":"Karunesh","family":"Ganguly","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of California, San Francisco; San Francisco, CA 94158, USA"},{"name":"California National Primate Research Center, University of California, Davis; Davis, CA 95616, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2026021603350738000_2026.02.10.705199v1.1","doi-asserted-by":"publisher","DOI":"10.1101\/2020.07.30.228767"},{"key":"2026021603350738000_2026.02.10.705199v1.2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-025-09690-9"},{"key":"2026021603350738000_2026.02.10.705199v1.3","doi-asserted-by":"publisher","DOI":"10.1016\/S0940-9602(11)80212-8"},{"key":"2026021603350738000_2026.02.10.705199v1.4","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1993.70.2.733"},{"key":"2026021603350738000_2026.02.10.705199v1.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2016.04.004"},{"key":"2026021603350738000_2026.02.10.705199v1.6","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00434.2001"},{"key":"2026021603350738000_2026.02.10.705199v1.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2004.08.006"},{"key":"2026021603350738000_2026.02.10.705199v1.8","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2016.00596"},{"key":"2026021603350738000_2026.02.10.705199v1.9","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2005.01.027"},{"key":"2026021603350738000_2026.02.10.705199v1.10","doi-asserted-by":"publisher","DOI":"10.1038\/nature03005"},{"key":"2026021603350738000_2026.02.10.705199v1.11","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1978.sp012517"},{"key":"2026021603350738000_2026.02.10.705199v1.12","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1978.sp012518"},{"key":"2026021603350738000_2026.02.10.705199v1.13","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902410405"},{"key":"2026021603350738000_2026.02.10.705199v1.14","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2015.03.020"},{"key":"2026021603350738000_2026.02.10.705199v1.15","doi-asserted-by":"publisher","DOI":"10.1016\/j.cophys.2021.04.002"},{"key":"2026021603350738000_2026.02.10.705199v1.16","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2024.02.036"},{"key":"2026021603350738000_2026.02.10.705199v1.17","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1316885110"},{"key":"2026021603350738000_2026.02.10.705199v1.18","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhaa191"},{"key":"2026021603350738000_2026.02.10.705199v1.19","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.109370"},{"key":"2026021603350738000_2026.02.10.705199v1.20","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0058-y"},{"key":"2026021603350738000_2026.02.10.705199v1.21","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.01.023"},{"key":"2026021603350738000_2026.02.10.705199v1.22","doi-asserted-by":"publisher","DOI":"10.1007\/s002210050830"},{"key":"2026021603350738000_2026.02.10.705199v1.23","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2025.09.013"},{"key":"2026021603350738000_2026.02.10.705199v1.24","doi-asserted-by":"publisher","DOI":"10.1038\/s43588-022-00282-5"},{"key":"2026021603350738000_2026.02.10.705199v1.25","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3256-05.2005"},{"key":"2026021603350738000_2026.02.10.705199v1.26","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2009.07.034"},{"key":"2026021603350738000_2026.02.10.705199v1.27","doi-asserted-by":"publisher","DOI":"10.1002\/cne.24453"},{"key":"2026021603350738000_2026.02.10.705199v1.28","doi-asserted-by":"publisher","DOI":"10.1101\/2024.10.11.617909"},{"key":"2026021603350738000_2026.02.10.705199v1.29","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1321-07.2007"},{"key":"2026021603350738000_2026.02.10.705199v1.30","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-020-0591-0"},{"key":"2026021603350738000_2026.02.10.705199v1.31","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2019.01.026"},{"key":"2026021603350738000_2026.02.10.705199v1.32","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-17902-1"},{"key":"2026021603350738000_2026.02.10.705199v1.33","doi-asserted-by":"publisher","DOI":"10.1152\/jn.90941.2008"},{"key":"2026021603350738000_2026.02.10.705199v1.34","doi-asserted-by":"publisher","DOI":"10.1101\/2023.01.07.523036"},{"key":"2026021603350738000_2026.02.10.705199v1.35","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-018-0209-y"},{"key":"2026021603350738000_2026.02.10.705199v1.36","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2011.10.020"},{"key":"2026021603350738000_2026.02.10.705199v1.37","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1224-23.2024"},{"key":"2026021603350738000_2026.02.10.705199v1.38","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5007-14.2015"},{"key":"2026021603350738000_2026.02.10.705199v1.39","doi-asserted-by":"publisher","DOI":"10.1038\/nature11129"},{"key":"2026021603350738000_2026.02.10.705199v1.40","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4042"},{"key":"2026021603350738000_2026.02.10.705199v1.41","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2018.01.004"},{"key":"2026021603350738000_2026.02.10.705199v1.42","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.67620"},{"key":"2026021603350738000_2026.02.10.705199v1.43","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-019-0407-2"},{"key":"2026021603350738000_2026.02.10.705199v1.44","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1869-9"},{"key":"2026021603350738000_2026.02.10.705199v1.45","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2022.06.024"},{"key":"2026021603350738000_2026.02.10.705199v1.46","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2014.07.022"},{"key":"2026021603350738000_2026.02.10.705199v1.47","doi-asserted-by":"publisher","DOI":"10.1523\/ENEURO.0085-16.2016"},{"key":"2026021603350738000_2026.02.10.705199v1.48","doi-asserted-by":"publisher","DOI":"10.1016\/j.neunet.2022.05.027"},{"key":"2026021603350738000_2026.02.10.705199v1.49","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-52477-1"},{"key":"2026021603350738000_2026.02.10.705199v1.50","first-page":"583","article-title":"Anatomical evidence concerning the role of the thalamus in corticocortical communication: a brief review","volume":"187","year":"1995","journal-title":"J Anat"},{"key":"2026021603350738000_2026.02.10.705199v1.51","doi-asserted-by":"publisher","DOI":"10.1002\/cphy.c160032"},{"key":"2026021603350738000_2026.02.10.705199v1.52","unstructured":"Usrey, W.M. , and Sherman, S.M. (2022). Exploring thalamocortical interactions: a partnership for sensation, action, and cognition (Oxford University Press)."},{"key":"2026021603350738000_2026.02.10.705199v1.53","doi-asserted-by":"publisher","DOI":"10.1101\/366567"},{"key":"2026021603350738000_2026.02.10.705199v1.54","doi-asserted-by":"crossref","unstructured":"Cappe, C. , Rouiller, E.M. , and Barone, P. (2012). Cortical and Thalamic Pathways for Multisensory and Sensorimotor Interplay. In The Neural Bases of Multisensory Processes Frontiers in Neuroscience., M. M. Murray and M. T. Wallace , eds. (CRC Press\/Taylor & Francis).","DOI":"10.1201\/b11092-4"},{"key":"2026021603350738000_2026.02.10.705199v1.55","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.109090"},{"key":"2026021603350738000_2026.02.10.705199v1.56","doi-asserted-by":"publisher","DOI":"10.1126\/science.7569931"},{"key":"2026021603350738000_2026.02.10.705199v1.57","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2005087117"},{"key":"2026021603350738000_2026.02.10.705199v1.58","doi-asserted-by":"publisher","DOI":"10.1017\/S0140525X00072599"},{"key":"2026021603350738000_2026.02.10.705199v1.59","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.10.041"},{"key":"2026021603350738000_2026.02.10.705199v1.60","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2014.04.045"},{"key":"2026021603350738000_2026.02.10.705199v1.61","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1005175"},{"key":"2026021603350738000_2026.02.10.705199v1.62","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-neuro-062111-150509"},{"key":"2026021603350738000_2026.02.10.705199v1.63","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-30069-1"},{"key":"2026021603350738000_2026.02.10.705199v1.64","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2025.103018"},{"key":"2026021603350738000_2026.02.10.705199v1.65","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-012-3041-8"},{"key":"2026021603350738000_2026.02.10.705199v1.66","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.13141"},{"key":"2026021603350738000_2026.02.10.705199v1.67","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2007.02.033"},{"key":"2026021603350738000_2026.02.10.705199v1.68","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhn229"},{"key":"2026021603350738000_2026.02.10.705199v1.69","doi-asserted-by":"publisher","DOI":"10.1038\/2245"},{"key":"2026021603350738000_2026.02.10.705199v1.70","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2017.06.007"},{"key":"2026021603350738000_2026.02.10.705199v1.71","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2021.01.049"},{"key":"2026021603350738000_2026.02.10.705199v1.72","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(84)91011-4"},{"key":"2026021603350738000_2026.02.10.705199v1.73","unstructured":"Gokcen, E. , Jasper, A.I. , Xu, A. , Kohn, A. , Machens, C.K. , and Yu, B.M. (2023). Uncovering motifs of concurrent signaling across multiple neuronal populations. NeurIPS 2023."},{"key":"2026021603350738000_2026.02.10.705199v1.74","doi-asserted-by":"publisher","DOI":"10.1162\/neco.a.22"},{"key":"2026021603350738000_2026.02.10.705199v1.75","doi-asserted-by":"publisher","DOI":"10.1101\/396572"},{"key":"2026021603350738000_2026.02.10.705199v1.76","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-019-0555-4"},{"key":"2026021603350738000_2026.02.10.705199v1.77","unstructured":"Rossant, C. (2025). Phy. (The Cortical Processing Laboratory at UCL)."},{"key":"2026021603350738000_2026.02.10.705199v1.78","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2010.06.020"}],"container-title":[],"original-title":[],"link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.64898\/2026.02.10.705199","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T11:35:15Z","timestamp":1771241715000},"score":1,"resource":{"primary":{"URL":"http:\/\/biorxiv.org\/lookup\/doi\/10.64898\/2026.02.10.705199"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,12]]},"references-count":78,"URL":"https:\/\/doi.org\/10.64898\/2026.02.10.705199","relation":{},"subject":[],"published":{"date-parts":[[2026,2,12]]},"subtype":"preprint"}}