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Assessing changes in retinal gene expression, differentially expressed genes were broadly comparable between diabetic mice experiencing washout of L-DOPA versus continued L-DOPA treatment, with gene co-expression network analysis identifying distinct modules across L-DOPA\u2013treated diabetic mice associated with synaptic function and cytoskeletal organization that correlated with functional protection. Together, these findings demonstrate that L-DOPA restores and sustains retinal neurovascular function in early DR and links this protection to transcriptional programs supporting synapse activity and structural integrity.<\/jats:p>\n                <jats:sec>\n                  <jats:title>Teaser<\/jats:title>\n                  <jats:p>L-DOPA restores neuronal and vascular performance in the diabetic retina, with benefits that lasted after treatment stopped.<\/jats:p>\n                <\/jats:sec>","DOI":"10.64898\/2026.02.17.706466","type":"posted-content","created":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T22:20:21Z","timestamp":1771453221000},"source":"Crossref","is-referenced-by-count":0,"title":["L-DOPA treatment promotes sustained neurovascular and synaptic homeostasis in the diabetic retina"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2701-4555","authenticated-orcid":false,"given":"Eli","family":"Chlan","sequence":"first","affiliation":[{"name":"Department of Ophthalmology and Neuroscience Program, Emory University"},{"name":"Joseph Maxwell Cleland Atlanta VA Medical Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenxing","family":"Li","sequence":"additional","affiliation":[{"name":"Wallace H. 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