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Recently, ultrawide-field-of-view (FOV) OCT played an increasingly significant clinical role; however, most clinical OCT systems offer only a rather limited FOV. We increased the FOV of clinical OCT by volumetrically montaging multiple OCT datasets in three dimensions (3D). We performed volumetric montaging by representing the internal limiting membrane (ILM) and retinal pigment epithelium (RPE) in each volume as point clouds and using these point clouds to compute transformations that map each volume to a common reference frame. We validated our methodology using datasets from three institutions with different OCT hardware and data-acquisition procedures. Using the mean surface distance between point clouds, we found the error in montaging was less than the lateral pixel size. Our method enabled existing clinical OCT to achieve ultrawide FOV imaging without any hardware modification.<\/jats:p>","DOI":"10.64898\/2026.02.21.706699","type":"posted-content","created":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T22:30:10Z","timestamp":1771885810000},"source":"Crossref","is-referenced-by-count":0,"title":["Volumetric montaging of optical coherence tomography in human retinas"],"prefix":"10.64898","author":[{"given":"Raymond","family":"Fang","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering, Northwestern University, Evanston IL"},{"name":"Department of Ophthalmology, Northwestern University Feinberg, Chicago IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengyuanshan","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Northwestern University, Evanston IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Northwestern University, Evanston IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"Zambrano","sequence":"additional","affiliation":[{"name":"Glaucoma Service, Wills Eye Hospital, Philadelphia, PA"},{"name":"Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA"},{"name":"School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Lam","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Hong Kong University Eye Centre, Hong Kong, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raphael","family":"Tinio","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Northwestern University Feinberg, Chicago IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2744-0896","authenticated-orcid":false,"given":"Cheng","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering, Northwestern University, Evanston IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher K. 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