{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T09:14:44Z","timestamp":1785402884500,"version":"3.56.0"},"posted":{"date-parts":[[2026,2,23]]},"group-title":"Microbiology","reference-count":40,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T00:00:00Z","timestamp":1771804800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"award":["AI 32606"],"award-info":[{"award-number":["AI 32606"]}],"id":[{"id":"https:\/\/ror.org\/01cwqze88","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,2,23]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                <jats:p>\n                  Gonorrhea, caused by\n                  <jats:italic>N. gonorrhoeae<\/jats:italic>\n                  , is a widespread sexually transmitted disease that is becoming resistant to all currently used antibiotics. Therefore, new therapeutics against gonorrhea are desperately needed. Here, we show that a natural product - aerocavin, is highly potent and specific against\n                  <jats:italic>Neisseria<\/jats:italic>\n                  . Aerocavin accumulates in\n                  <jats:italic>N. gonorrhoeae<\/jats:italic>\n                  at high levels and inhibits bacterial RNA polymerase (RNAP) by binding the switch region. Aerocavin resistance mutations evolve in\n                  <jats:italic>N. gonorrhoeae<\/jats:italic>\n                  at a low rate and are absent in clinical isolates. Previously overlooked narrow-spectrum antimicrobials like aerocavin may enable microbiome-sparing treatments of gonorrhea.\n                <\/jats:p>","DOI":"10.64898\/2026.02.23.707490","type":"posted-content","created":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T03:05:17Z","timestamp":1771902317000},"source":"Crossref","is-referenced-by-count":0,"title":["Aerocavin is an antibiotic with potent and specific anti-Neisserial activity"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9303-010X","authenticated-orcid":false,"given":"Gleb","family":"Pishchany","sequence":"first","affiliation":[{"name":"Center for Therapeutics, Toxicology, and Devices, RTI International, Durham, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyra E.","family":"Fryling","sequence":"additional","affiliation":[{"name":"Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9327-0955","authenticated-orcid":false,"given":"Vineetha","family":"Vasukuttan","sequence":"additional","affiliation":[{"name":"Center for Therapeutics, Toxicology, and Devices, RTI International, Durham, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4645-2128","authenticated-orcid":false,"given":"Yern-Hyerk","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School and Blavatnik Institute, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6255-690X","authenticated-orcid":false,"given":"Tatum D","family":"Mortimer","sequence":"additional","affiliation":[{"name":"Department of Population Health, University of Georgia, Athens, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5646-1314","authenticated-orcid":false,"given":"Yonatan H.","family":"Grad","sequence":"additional","affiliation":[{"name":"Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon","family":"Clardy","sequence":"additional","affiliation":[{"name":"Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School and Blavatnik Institute, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2026022606200782000_2026.02.23.707490v1.1","unstructured":"Gonorrhea - CDC Detailed Fact Sheet. CDC, https:\/\/www.cdc.gov\/std\/gonorrhea\/stdfact-gonorrhea-detailed.htm (accessed 2023."},{"key":"2026022606200782000_2026.02.23.707490v1.2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.23487"},{"key":"2026022606200782000_2026.02.23.707490v1.3","unstructured":"Global progress report on HIV, viral hepatitis and sexually transmitted infections, Global HIV, Hepatitis and Sexually Transmitted Infections Programmes; 2021. https:\/\/www.who.int\/publications\/i\/item\/9789240027077."},{"key":"2026022606200782000_2026.02.23.707490v1.4","unstructured":"National Overview of STIs in 2023. 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